ENSG00000100379

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000402077 ENSG00000100379 HEK293_OSMI2_2hA HEK293_TMG_2hB KCTD17 protein_coding protein_coding 44.68896 89.48294 22.14116 4.446316 0.5321205 -2.014392 20.6026592 41.778396 9.409475 3.0073568 0.2424825 -2.1493839 0.44671250 0.465833333 0.42560000 -0.040233333 0.48427562 0.01377677 FALSE TRUE
ENST00000456470 ENSG00000100379 HEK293_OSMI2_2hA HEK293_TMG_2hB KCTD17 protein_coding protein_coding 44.68896 89.48294 22.14116 4.446316 0.5321205 -2.014392 3.6310505 9.164545 2.183463 0.3575654 0.1535657 -2.0644264 0.07088333 0.102533333 0.09850000 -0.004033333 0.90112767 0.01377677 FALSE TRUE
ENST00000462640 ENSG00000100379 HEK293_OSMI2_2hA HEK293_TMG_2hB KCTD17 protein_coding retained_intron 44.68896 89.48294 22.14116 4.446316 0.5321205 -2.014392 1.8639123 2.934888 1.833191 1.9319781 0.2234343 -0.6760077 0.04994583 0.031300000 0.08283333 0.051533333 0.53414145 0.01377677 FALSE TRUE
ENST00000483389 ENSG00000100379 HEK293_OSMI2_2hA HEK293_TMG_2hB KCTD17 protein_coding retained_intron 44.68896 89.48294 22.14116 4.446316 0.5321205 -2.014392 0.7575075 0.301961 1.324061 0.1551202 0.5310030 2.0963867 0.02687917 0.003533333 0.05876667 0.055233333 0.01377677 0.01377677 FALSE FALSE
ENST00000610767 ENSG00000100379 HEK293_OSMI2_2hA HEK293_TMG_2hB KCTD17 protein_coding protein_coding 44.68896 89.48294 22.14116 4.446316 0.5321205 -2.014392 3.8987684 9.648354 2.204173 1.2271999 0.4269317 -2.1250096 0.07771667 0.109100000 0.09940000 -0.009700000 0.91152661 0.01377677 FALSE TRUE
MSTRG.22059.1 ENSG00000100379 HEK293_OSMI2_2hA HEK293_TMG_2hB KCTD17 protein_coding   44.68896 89.48294 22.14116 4.446316 0.5321205 -2.014392 3.1395706 4.171919 1.981603 1.0674420 0.3930889 -1.0702352 0.07684583 0.045966667 0.08936667 0.043400000 0.19224214 0.01377677 TRUE TRUE
MSTRG.22059.10 ENSG00000100379 HEK293_OSMI2_2hA HEK293_TMG_2hB KCTD17 protein_coding   44.68896 89.48294 22.14116 4.446316 0.5321205 -2.014392 6.5467022 12.634402 2.209922 1.4702503 0.1828992 -2.5099178 0.14190000 0.142433333 0.09970000 -0.042733333 0.33321219 0.01377677 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100379 E001 0.3289534 0.0283079947 2.706571e-01   22 37051711 37051711 1 + 0.225 0.063 -2.129
ENSG00000100379 E002 8.4699409 0.0860759618 1.678285e-01 0.2853734552 22 37051712 37051738 27 + 1.022 0.814 -0.786
ENSG00000100379 E003 9.6449343 0.0907484783 2.224568e-01 0.3533245604 22 37051739 37051741 3 + 1.049 0.867 -0.680
ENSG00000100379 E004 41.7580201 0.0332860198 3.967365e-02 0.0904219646 22 37051742 37051760 19 + 1.643 1.457 -0.634
ENSG00000100379 E005 109.8530886 0.0097313616 1.651806e-02 0.0438818272 22 37051761 37051851 91 + 2.008 1.884 -0.417
ENSG00000100379 E006 155.5821151 0.0024355003 2.544333e-02 0.0627944168 22 37051852 37051875 24 + 2.115 2.041 -0.248
ENSG00000100379 E007 234.3368957 0.0026732411 1.509049e-01 0.2628946861 22 37051876 37051904 29 + 2.259 2.226 -0.109
ENSG00000100379 E008 301.0343898 0.0008856254 4.320972e-02 0.0969359799 22 37051905 37051949 45 + 2.371 2.332 -0.130
ENSG00000100379 E009 0.1817044 0.0393958044 1.000000e+00   22 37052170 37052632 463 + 0.001 0.063 6.669
ENSG00000100379 E010 1.4810325 0.1084616582 1.043636e-01 0.1971343095 22 37053065 37053099 35 + 0.571 0.249 -1.812
ENSG00000100379 E011 464.1876117 0.0001214489 9.489357e-02 0.1827203017 22 37053100 37053208 109 + 2.542 2.525 -0.055
ENSG00000100379 E012 503.4387303 0.0001226394 3.976288e-01 0.5413825113 22 37056320 37056411 92 + 2.562 2.564 0.005
ENSG00000100379 E013 1.8874163 0.0098212112 4.523912e-01 0.5932520079 22 37057368 37057397 30 + 0.483 0.351 -0.714
ENSG00000100379 E014 468.3814889 0.0009062086 6.552152e-01 0.7651534835 22 37057398 37057493 96 + 2.507 2.539 0.104
ENSG00000100379 E015 465.0141697 0.0006510629 5.952170e-01 0.7173342711 22 37059313 37059438 126 + 2.503 2.535 0.109
ENSG00000100379 E016 1.8111463 0.0079994050 2.469583e-04 0.0011626041 22 37059439 37059516 78 + 0.809 0.210 -3.131
ENSG00000100379 E017 246.7579839 0.0008611018 4.228201e-01 0.5659639328 22 37060823 37060891 69 + 2.262 2.256 -0.021
ENSG00000100379 E018 57.4662811 0.0004085894 3.355121e-01 0.4792953742 22 37060892 37060897 6 + 1.662 1.623 -0.134
ENSG00000100379 E019 117.3386055 0.0002902880 9.363465e-02 0.1808070930 22 37060898 37060922 25 + 1.852 1.946 0.317
ENSG00000100379 E020 102.3729675 0.0043035142 4.501386e-01 0.5912884793 22 37060923 37061103 181 + 1.892 1.872 -0.068
ENSG00000100379 E021 113.2063188 0.0003196043 5.314898e-01 0.6639223955 22 37061104 37061175 72 + 1.924 1.915 -0.031
ENSG00000100379 E022 164.1484483 0.0002562756 4.648355e-02 0.1029094591 22 37061176 37061384 209 + 2.122 2.069 -0.176
ENSG00000100379 E023 125.2443455 0.0013296753 3.684192e-01 0.5128338633 22 37061385 37061538 154 + 1.981 1.960 -0.068
ENSG00000100379 E024 293.0285778 0.0005091458 2.470770e-01 0.3824964724 22 37061539 37061629 91 + 2.339 2.325 -0.045
ENSG00000100379 E025 1281.9811174 0.0037624778 1.746856e-05 0.0001097962 22 37062525 37063390 866 + 2.853 2.991 0.461