ENSG00000100372

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435456 ENSG00000100372 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A17 protein_coding protein_coding 53.34395 47.56421 64.50765 10.46077 1.323004 0.439514 21.425758 20.7569516 26.188242 4.8036553 2.3164488 0.3351805 0.40100000 0.434600000 0.4065 -0.02810000 0.813770014 0.002656757 FALSE TRUE
ENST00000447566 ENSG00000100372 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A17 protein_coding nonsense_mediated_decay 53.34395 47.56421 64.50765 10.46077 1.323004 0.439514 10.501364 7.4516028 13.374519 1.0275589 0.9514406 0.8430078 0.19410833 0.162966667 0.2081 0.04513333 0.444403146 0.002656757 FALSE TRUE
MSTRG.22162.5 ENSG00000100372 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A17 protein_coding   53.34395 47.56421 64.50765 10.46077 1.323004 0.439514 12.111930 15.3763194 11.023684 4.3149251 1.6671742 -0.4797336 0.23402917 0.315900000 0.1700 -0.14590000 0.002656757 0.002656757 FALSE FALSE
MSTRG.22162.8 ENSG00000100372 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A17 protein_coding   53.34395 47.56421 64.50765 10.46077 1.323004 0.439514 2.706259 0.2138736 4.709303 0.2138736 2.5478034 4.3978177 0.04677917 0.003166667 0.0730 0.06983333 0.029028568 0.002656757 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100372 E001 88.031009 0.0011874181 8.004346e-01 8.727880e-01 22 40769630 40770087 458 - 1.953 1.968 0.050
ENSG00000100372 E002 487.310537 0.0045427258 1.023303e-03 4.039121e-03 22 40770088 40770488 401 - 2.631 2.741 0.367
ENSG00000100372 E003 226.410556 0.0009172774 1.192440e-06 9.741946e-06 22 40770489 40770538 50 - 2.292 2.425 0.446
ENSG00000100372 E004 835.342472 0.0001871637 6.293115e-05 3.458092e-04 22 40770539 40770894 356 - 2.904 2.959 0.183
ENSG00000100372 E005 399.928163 0.0002376172 6.866968e-01 7.891647e-01 22 40770895 40770981 87 - 2.608 2.620 0.038
ENSG00000100372 E006 379.942537 0.0001740417 5.168714e-01 6.513782e-01 22 40773937 40774019 83 - 2.584 2.600 0.054
ENSG00000100372 E007 1.704569 0.0097592315 8.518801e-01 9.081789e-01 22 40776190 40776308 119 - 0.458 0.431 -0.139
ENSG00000100372 E008 285.261634 0.0001717965 2.907568e-01 4.315531e-01 22 40777040 40777059 20 - 2.455 2.482 0.090
ENSG00000100372 E009 382.729625 0.0001999163 5.896621e-01 7.126980e-01 22 40777060 40777135 76 - 2.588 2.602 0.046
ENSG00000100372 E010 385.430795 0.0002291203 9.157702e-01 9.507234e-01 22 40777228 40777298 71 - 2.594 2.599 0.017
ENSG00000100372 E011 322.506615 0.0008269760 4.774496e-01 6.159912e-01 22 40777299 40777337 39 - 2.527 2.511 -0.053
ENSG00000100372 E012 255.708154 0.0031465404 4.498273e-01 5.910298e-01 22 40777338 40777359 22 - 2.432 2.398 -0.112
ENSG00000100372 E013 239.662765 0.0027359507 6.293680e-01 7.447430e-01 22 40777360 40777373 14 - 2.399 2.377 -0.073
ENSG00000100372 E014 278.064976 0.0001969381 6.083903e-02 1.280499e-01 22 40779009 40779033 25 - 2.475 2.440 -0.117
ENSG00000100372 E015 291.524547 0.0001635004 4.422296e-02 9.879840e-02 22 40779034 40779061 28 - 2.496 2.459 -0.123
ENSG00000100372 E016 266.744499 0.0001552742 5.997229e-02 1.265591e-01 22 40779062 40779077 16 - 2.457 2.421 -0.120
ENSG00000100372 E017 300.683010 0.0001551232 4.652514e-02 1.029871e-01 22 40779078 40779125 48 - 2.509 2.474 -0.118
ENSG00000100372 E018 7.390658 0.0348069877 7.046201e-01 8.031247e-01 22 40779126 40779757 632 - 0.959 0.891 -0.257
ENSG00000100372 E019 3.628519 0.0045675407 9.717912e-01 9.863855e-01 22 40779758 40779894 137 - 0.676 0.675 -0.001
ENSG00000100372 E020 2.928795 0.0067717257 9.334284e-01 9.620507e-01 22 40779895 40780255 361 - 0.614 0.608 -0.029
ENSG00000100372 E021 1.999092 0.0075495264 6.946643e-01 7.954407e-01 22 40784513 40784604 92 - 0.458 0.528 0.346
ENSG00000100372 E022 169.504882 0.0002262020 2.008266e-01 3.272155e-01 22 40792525 40792531 7 - 2.258 2.228 -0.100
ENSG00000100372 E023 299.103934 0.0003258106 1.259356e-02 3.495440e-02 22 40792532 40792595 64 - 2.513 2.462 -0.169
ENSG00000100372 E024 255.081110 0.0007063705 1.191452e-01 2.187159e-01 22 40792596 40792676 81 - 2.437 2.399 -0.126
ENSG00000100372 E025 221.443160 0.0024001066 7.351261e-02 1.491421e-01 22 40794514 40794580 67 - 2.387 2.322 -0.215
ENSG00000100372 E026 0.147249 0.0465634381 5.625858e-01   22 40797254 40797283 30 - 0.118 0.000 -9.302
ENSG00000100372 E027 2.414073 0.0288499795 1.242445e-01 2.260442e-01 22 40797284 40797336 53 - 0.646 0.374 -1.330
ENSG00000100372 E028 171.845842 0.0034895829 6.624472e-01 7.707483e-01 22 40799023 40799040 18 - 2.257 2.232 -0.084
ENSG00000100372 E029 262.379501 0.0044459081 1.223925e-01 2.233611e-01 22 40799041 40799083 43 - 2.461 2.390 -0.236
ENSG00000100372 E030 1.183516 0.0869197032 3.772970e-01 5.216256e-01 22 40799561 40799671 111 - 0.408 0.227 -1.179
ENSG00000100372 E031 3.155239 0.0761949308 2.096902e-03 7.524563e-03 22 40817203 40817377 175 - 0.839 0.225 -3.116
ENSG00000100372 E032 297.282632 0.0111468537 3.322437e-01 4.758715e-01 22 40819195 40819399 205 - 2.511 2.444 -0.223