ENSG00000100364

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336156 ENSG00000100364 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0930 protein_coding protein_coding 47.89546 80.55194 33.51927 4.243807 0.30442 -1.264677 6.735799 7.685998 7.329301 0.4810598 0.09157131 -0.0684658 0.16260417 0.09606667 0.2186667 0.12260000 9.427664e-10 1.26131e-10 FALSE TRUE
ENST00000391627 ENSG00000100364 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0930 protein_coding protein_coding 47.89546 80.55194 33.51927 4.243807 0.30442 -1.264677 22.638652 36.238031 13.947187 2.3957966 0.49102833 -1.3768944 0.46620833 0.45020000 0.4163000 -0.03390000 6.744886e-01 1.26131e-10 FALSE TRUE
ENST00000423262 ENSG00000100364 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0930 protein_coding protein_coding 47.89546 80.55194 33.51927 4.243807 0.30442 -1.264677 2.876267 9.525786 0.000000 2.7930865 0.00000000 -9.8972080 0.03934167 0.12096667 0.0000000 -0.12096667 1.261310e-10 1.26131e-10 FALSE TRUE
MSTRG.22314.5 ENSG00000100364 HEK293_OSMI2_2hA HEK293_TMG_2hB KIAA0930 protein_coding   47.89546 80.55194 33.51927 4.243807 0.30442 -1.264677 14.347200 25.393285 11.023997 3.6431135 0.67339864 -1.2030596 0.30135833 0.31206667 0.3286333 0.01656667 8.905664e-01 1.26131e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100364 E001 677.3593078 0.0061137138 1.316597e-17 6.367766e-16 22 45192244 45195827 3584 - 2.991 2.661 -1.098
ENSG00000100364 E002 276.8755196 0.0018554914 9.881138e-01 9.966151e-01 22 45195828 45196037 210 - 2.385 2.382 -0.011
ENSG00000100364 E003 1646.4222093 0.0019808488 2.707448e-08 3.075048e-07 22 45196038 45196701 664 - 3.066 3.181 0.381
ENSG00000100364 E004 433.9733316 0.0006883450 1.769631e-06 1.392471e-05 22 45196702 45196748 47 - 2.492 2.598 0.354
ENSG00000100364 E005 489.7327266 0.0046145679 1.968347e-03 7.126972e-03 22 45196749 45196963 215 - 2.542 2.654 0.373
ENSG00000100364 E006 290.9013271 0.0007605660 4.879723e-11 9.082815e-10 22 45196964 45197105 142 - 2.257 2.438 0.603
ENSG00000100364 E007 359.3389584 0.0008912461 2.921863e-08 3.295655e-07 22 45197106 45197216 111 - 2.382 2.523 0.469
ENSG00000100364 E008 593.2679031 0.0006120655 2.259314e-01 3.575088e-01 22 45197790 45197948 159 - 2.694 2.714 0.065
ENSG00000100364 E009 1.8726530 0.0084516997 1.439548e-01 2.533966e-01 22 45197949 45198033 85 - 0.179 0.458 1.874
ENSG00000100364 E010 625.1288713 0.0003053442 5.357363e-01 6.675324e-01 22 45199873 45200035 163 - 2.743 2.727 -0.052
ENSG00000100364 E011 7.9285032 0.0021525330 6.192065e-01 7.366760e-01 22 45200036 45200209 174 - 0.937 0.871 -0.250
ENSG00000100364 E012 2.0574805 0.0070867896 7.587020e-01 8.432213e-01 22 45202563 45202593 31 - 0.483 0.425 -0.297
ENSG00000100364 E013 3.5228323 0.0785151276 6.145144e-01 7.329526e-01 22 45202594 45202715 122 - 0.660 0.574 -0.377
ENSG00000100364 E014 448.1273461 0.0002120634 1.844565e-01 3.068115e-01 22 45202990 45203130 141 - 2.610 2.579 -0.104
ENSG00000100364 E015 284.3952077 0.0012316235 4.035507e-01 5.473252e-01 22 45203131 45203184 54 - 2.410 2.382 -0.093
ENSG00000100364 E016 491.2910795 0.0001570491 1.477720e-01 2.586523e-01 22 45203845 45203985 141 - 2.651 2.619 -0.106
ENSG00000100364 E017 265.2224495 0.0001846254 3.177576e-01 4.606432e-01 22 45205217 45205220 4 - 2.384 2.353 -0.101
ENSG00000100364 E018 260.5363508 0.0002010206 3.368206e-01 4.806899e-01 22 45205221 45205222 2 - 2.375 2.346 -0.098
ENSG00000100364 E019 349.5894139 0.0003550263 5.888579e-02 1.247231e-01 22 45205223 45205259 37 - 2.517 2.469 -0.158
ENSG00000100364 E020 400.2780601 0.0003257932 1.137841e-01 2.110381e-01 22 45205260 45205318 59 - 2.568 2.530 -0.128
ENSG00000100364 E021 274.8261183 0.0001943629 3.449994e-01 4.890712e-01 22 45205630 45205641 12 - 2.398 2.370 -0.095
ENSG00000100364 E022 426.5531474 0.0010648232 9.162045e-01 9.510180e-01 22 45205642 45205707 66 - 2.572 2.565 -0.022
ENSG00000100364 E023 445.2449807 0.0004321100 6.120305e-01 7.310622e-01 22 45205793 45205883 91 - 2.596 2.580 -0.052
ENSG00000100364 E024 257.9808981 0.0004161677 5.832293e-02 1.237510e-01 22 45205884 45205912 29 - 2.389 2.335 -0.180
ENSG00000100364 E025 0.5503986 0.0204020836 8.733162e-01 9.226037e-01 22 45207573 45207772 200 - 0.179 0.151 -0.296
ENSG00000100364 E026 0.0000000       22 45211334 45211334 1 -      
ENSG00000100364 E027 0.7761102 0.0354092215 8.621343e-01 9.151189e-01 22 45211335 45211432 98 - 0.179 0.211 0.294
ENSG00000100364 E028 320.0848364 0.0015809595 5.324086e-02 1.149124e-01 22 45211956 45212107 152 - 2.487 2.428 -0.197
ENSG00000100364 E029 0.1451727 0.0431858796 1.994977e-01   22 45212108 45212264 157 - 0.179 0.000 -11.915
ENSG00000100364 E030 0.4031496 0.0246259658 5.658565e-01 6.928903e-01 22 45212265 45212488 224 - 0.000 0.151 10.047
ENSG00000100364 E031 0.0000000       22 45213321 45213499 179 -      
ENSG00000100364 E032 0.0000000       22 45226152 45226383 232 -      
ENSG00000100364 E033 0.1472490 0.0429694904 1.994743e-01   22 45226780 45226903 124 - 0.179 0.000 -11.915
ENSG00000100364 E034 0.3268771 0.0292585103 5.184643e-01   22 45235249 45235413 165 - 0.179 0.082 -1.297
ENSG00000100364 E035 0.2214452 0.0387959601 1.000000e+00   22 45236170 45236277 108 - 0.000 0.082 9.048
ENSG00000100364 E036 0.6265839 0.0735029196 2.223923e-01 3.532481e-01 22 45239212 45239326 115 - 0.000 0.260 11.027
ENSG00000100364 E037 97.7821790 0.0074520328 1.047341e-01 1.977158e-01 22 45240640 45240894 255 - 2.000 1.906 -0.316