ENSG00000100330

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323630 ENSG00000100330 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR3 protein_coding protein_coding 11.88991 10.4213 10.25901 0.8371228 0.655505 -0.02262175 1.8246898 1.7507658 0.93269461 0.1646003 0.46444750 -0.90134062 0.14995417 0.16783333 0.0893000 -0.078533333 0.47862581 0.02507693 FALSE TRUE
ENST00000351488 ENSG00000100330 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR3 protein_coding protein_coding 11.88991 10.4213 10.25901 0.8371228 0.655505 -0.02262175 2.6116210 2.6542442 2.63471249 0.1761991 0.18134970 -0.01061542 0.22468750 0.25743333 0.2603667 0.002933333 1.00000000 0.02507693 FALSE TRUE
ENST00000401950 ENSG00000100330 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR3 protein_coding protein_coding 11.88991 10.4213 10.25901 0.8371228 0.655505 -0.02262175 4.1179435 3.9376408 2.72190183 0.7489059 0.52335651 -0.53108510 0.34724167 0.37620000 0.2687333 -0.107466667 0.51241408 0.02507693 FALSE TRUE
ENST00000491251 ENSG00000100330 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR3 protein_coding retained_intron 11.88991 10.4213 10.25901 0.8371228 0.655505 -0.02262175 0.2391197 0.8764287 0.02647484 0.5677463 0.01688108 -4.60303089 0.02104583 0.08313333 0.0025000 -0.080633333 0.03119580 0.02507693 FALSE FALSE
ENST00000492087 ENSG00000100330 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR3 protein_coding retained_intron 11.88991 10.4213 10.25901 0.8371228 0.655505 -0.02262175 1.9579544 0.1730835 1.89742306 0.1730835 0.32429256 3.38105138 0.15972500 0.01566667 0.1823667 0.166700000 0.02507693 0.02507693 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100330 E001 1.177084 0.0110564035 9.732047e-01 9.872902e-01 22 29883169 29883173 5 + 0.311 0.345 0.210
ENSG00000100330 E002 1.324333 0.0101971556 6.624882e-01 7.707771e-01 22 29883174 29883178 5 + 0.380 0.345 -0.205
ENSG00000100330 E003 4.337681 0.1718808896 4.925150e-01 6.296851e-01 22 29883179 29883196 18 + 0.744 0.700 -0.180
ENSG00000100330 E004 4.484930 0.1395443639 3.944115e-01 5.382476e-01 22 29883197 29883197 1 + 0.771 0.700 -0.290
ENSG00000100330 E005 7.239119 0.0439963819 5.975615e-02 1.262040e-01 22 29883198 29883212 15 + 1.018 0.811 -0.784
ENSG00000100330 E006 17.662679 0.0876476694 4.932669e-02 1.079686e-01 22 29883213 29883268 56 + 1.386 1.142 -0.857
ENSG00000100330 E007 34.147001 0.0304814360 7.357207e-03 2.214562e-02 22 29883269 29883359 91 + 1.646 1.439 -0.707
ENSG00000100330 E008 41.989282 0.0005875972 1.652114e-05 1.044303e-04 22 29957036 29957088 53 + 1.710 1.551 -0.542
ENSG00000100330 E009 45.665214 0.0004940734 1.208583e-03 4.669844e-03 22 29970976 29971050 75 + 1.716 1.622 -0.319
ENSG00000100330 E010 28.412708 0.0007102454 3.423680e-02 8.021147e-02 22 29971051 29971062 12 + 1.502 1.437 -0.223
ENSG00000100330 E011 1.102888 0.0119193250 4.325739e-01 5.750099e-01 22 29978087 29978424 338 + 0.380 0.281 -0.622
ENSG00000100330 E012 1.072699 0.0117135960 1.224855e-01 2.234921e-01 22 29978425 29978441 17 + 0.439 0.206 -1.529
ENSG00000100330 E013 57.754289 0.0004025744 8.896084e-07 7.468477e-06 22 29978442 29978531 90 + 1.846 1.694 -0.514
ENSG00000100330 E014 66.922290 0.0019179795 4.624253e-04 2.015903e-03 22 29978936 29979052 117 + 1.876 1.784 -0.310
ENSG00000100330 E015 61.010951 0.0012414330 4.257473e-06 3.076146e-05 22 29988480 29988562 83 + 1.863 1.720 -0.483
ENSG00000100330 E016 83.339625 0.0003637220 5.014287e-05 2.825694e-04 22 29991504 29991670 167 + 1.966 1.883 -0.279
ENSG00000100330 E017 71.427129 0.0004433489 1.623477e-04 8.020517e-04 22 29998761 29998857 97 + 1.899 1.815 -0.285
ENSG00000100330 E018 65.952007 0.0213422063 2.998801e-02 7.193591e-02 22 30002880 30002993 114 + 1.872 1.774 -0.330
ENSG00000100330 E019 2.039865 0.0756470254 4.616223e-01 6.015449e-01 22 30003895 30004021 127 + 0.538 0.447 -0.444
ENSG00000100330 E020 87.513300 0.0082163702 4.140191e-05 2.377889e-04 22 30007114 30007319 206 + 2.025 1.869 -0.523
ENSG00000100330 E021 66.057117 0.0033978190 3.427727e-03 1.151778e-02 22 30007901 30008032 132 + 1.865 1.789 -0.256
ENSG00000100330 E022 69.751486 0.0004441864 8.876792e-03 2.597192e-02 22 30009018 30009129 112 + 1.867 1.830 -0.125
ENSG00000100330 E023 88.064799 0.0040081198 4.482674e-03 1.449246e-02 22 30012368 30012563 196 + 1.978 1.917 -0.203
ENSG00000100330 E024 88.936607 0.0006960582 2.036836e-01 3.308120e-01 22 30013356 30013541 186 + 1.932 1.956 0.081
ENSG00000100330 E025 94.546011 0.0029969988 8.322191e-01 8.948527e-01 22 30016528 30016698 171 + 1.934 1.999 0.217
ENSG00000100330 E026 3.323401 0.1371373330 1.099835e-01 2.055160e-01 22 30017683 30017926 244 + 0.770 0.524 -1.060
ENSG00000100330 E027 78.061351 0.0063664211 5.006600e-01 6.368922e-01 22 30017927 30018072 146 + 1.870 1.906 0.122
ENSG00000100330 E028 447.427394 0.0001809791 1.695688e-01 2.876356e-01 22 30019480 30020884 1405 + 2.616 2.668 0.172
ENSG00000100330 E029 49.058263 0.0005200703 1.888801e-03 6.879582e-03 22 30022029 30022139 111 + 1.547 1.783 0.801
ENSG00000100330 E030 2.916081 0.0969464009 6.099538e-01 7.293459e-01 22 30022463 30022608 146 + 0.491 0.639 0.678
ENSG00000100330 E031 74.662139 0.0003411984 1.403959e-01 2.485740e-01 22 30022609 30022697 89 + 1.791 1.926 0.454
ENSG00000100330 E032 3.432152 0.0293848669 6.520476e-01 7.627886e-01 22 30023457 30023483 27 + 0.653 0.636 -0.070
ENSG00000100330 E033 1141.062198 0.0074532150 7.291455e-09 9.213877e-08 22 30025630 30030868 5239 + 2.900 3.135 0.783