ENSG00000100239

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395744 ENSG00000100239 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6R2 protein_coding protein_coding 44.88863 62.88912 27.53244 2.345371 1.1003 -1.191384 3.7507011 6.031338 0.922730 2.44156081 0.9227300 -2.6953366 0.079020833 0.09463333 0.03490000 -0.05973333 2.197078e-01 2.179745e-18 FALSE TRUE
ENST00000401672 ENSG00000100239 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6R2 protein_coding protein_coding 44.88863 62.88912 27.53244 2.345371 1.1003 -1.191384 4.1695163 10.574098 0.000000 2.50586649 0.0000000 -10.0476826 0.071462500 0.16640000 0.00000000 -0.16640000 2.179745e-18 2.179745e-18 FALSE TRUE
ENST00000427222 ENSG00000100239 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6R2 protein_coding protein_coding 44.88863 62.88912 27.53244 2.345371 1.1003 -1.191384 0.5316559 3.655600 0.000000 2.02276006 0.0000000 -8.5179057 0.008808333 0.06006667 0.00000000 -0.06006667 3.192004e-05 2.179745e-18 FALSE TRUE
ENST00000470046 ENSG00000100239 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6R2 protein_coding retained_intron 44.88863 62.88912 27.53244 2.345371 1.1003 -1.191384 6.4803650 5.876820 3.873574 0.67406210 0.2620778 -0.6001036 0.143341667 0.09303333 0.14103333 0.04800000 4.947426e-02 2.179745e-18 FALSE FALSE
ENST00000473283 ENSG00000100239 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6R2 protein_coding retained_intron 44.88863 62.88912 27.53244 2.345371 1.1003 -1.191384 2.5546767 2.968092 1.658766 0.09300801 0.5071684 -0.8356064 0.057887500 0.04723333 0.05906667 0.01183333 8.235441e-01 2.179745e-18   FALSE
ENST00000612753 ENSG00000100239 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6R2 protein_coding protein_coding 44.88863 62.88912 27.53244 2.345371 1.1003 -1.191384 6.8136105 13.017482 3.588698 0.20283404 0.3827668 -1.8560113 0.139983333 0.20733333 0.12976667 -0.07756667 5.170834e-04 2.179745e-18 FALSE TRUE
MSTRG.22375.13 ENSG00000100239 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6R2 protein_coding   44.88863 62.88912 27.53244 2.345371 1.1003 -1.191384 8.1854809 7.870862 5.932928 1.04801525 0.4589660 -0.4071797 0.202129167 0.12616667 0.21613333 0.08996667 5.783353e-02 2.179745e-18 TRUE TRUE
MSTRG.22375.22 ENSG00000100239 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6R2 protein_coding   44.88863 62.88912 27.53244 2.345371 1.1003 -1.191384 3.4809629 2.354967 2.794931 0.21923892 0.1354378 0.2461449 0.082795833 0.03763333 0.10143333 0.06380000 3.847401e-08 2.179745e-18 FALSE TRUE
MSTRG.22375.9 ENSG00000100239 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP6R2 protein_coding   44.88863 62.88912 27.53244 2.345371 1.1003 -1.191384 3.1074507 2.188937 3.350204 1.12172596 0.3604618 0.6117429 0.077145833 0.03383333 0.12106667 0.08723333 4.555124e-01 2.179745e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100239 E001 1.333885 0.0106573076 3.751080e-02 8.642411e-02 22 50343304 50343320 17 + 0.570 0.200 -2.210
ENSG00000100239 E002 1.333885 0.0106573076 3.751080e-02 8.642411e-02 22 50343321 50343322 2 + 0.570 0.200 -2.211
ENSG00000100239 E003 2.657174 0.0062838318 3.356399e-03 1.131061e-02 22 50343323 50343326 4 + 0.808 0.337 -2.211
ENSG00000100239 E004 2.955939 0.0073238797 5.638604e-04 2.398600e-03 22 50343327 50343329 3 + 0.876 0.337 -2.473
ENSG00000100239 E005 3.399876 0.0053343014 2.943143e-05 1.754853e-04 22 50343330 50343330 1 + 0.961 0.337 -2.796
ENSG00000100239 E006 3.918009 0.0046463366 1.044351e-05 6.913694e-05 22 50343331 50343331 1 + 1.010 0.374 -2.754
ENSG00000100239 E007 4.769362 0.0066608560 4.557811e-06 3.274913e-05 22 50343332 50343334 3 + 1.074 0.441 -2.624
ENSG00000100239 E008 6.654807 0.0055931039 1.609950e-08 1.909951e-07 22 50343335 50343339 5 + 1.224 0.525 -2.746
ENSG00000100239 E009 6.799979 0.0047445862 5.399950e-09 7.003042e-08 22 50343340 50343341 2 + 1.238 0.525 -2.795
ENSG00000100239 E010 8.159903 0.0039779911 6.399282e-12 1.374986e-10 22 50343342 50343344 3 + 1.335 0.549 -3.021
ENSG00000100239 E011 8.785545 0.0043347575 1.223564e-12 2.961930e-11 22 50343345 50343345 1 + 1.366 0.573 -3.023
ENSG00000100239 E012 11.804041 0.0019742273 9.113017e-17 3.947939e-15 22 50343346 50343346 1 + 1.489 0.673 -3.007
ENSG00000100239 E013 17.060767 0.0267317206 4.315198e-12 9.534656e-11 22 50343347 50343355 9 + 1.625 0.843 -2.789
ENSG00000100239 E014 21.955154 0.0784822275 3.779091e-07 3.424064e-06 22 50343356 50343368 13 + 1.725 0.962 -2.673
ENSG00000100239 E015 81.982240 0.0310173043 1.204668e-03 4.656046e-03 22 50343369 50343550 182 + 2.050 1.753 -0.998
ENSG00000100239 E016 1.101742 0.2569992037 5.312536e-01 6.637368e-01 22 50360134 50360195 62 + 0.419 0.247 -1.085
ENSG00000100239 E017 75.126018 0.0113068063 8.107921e-03 2.405559e-02 22 50372020 50372071 52 + 1.935 1.754 -0.611
ENSG00000100239 E018 136.725618 0.0103221261 1.884809e-03 6.867286e-03 22 50372072 50372150 79 + 2.197 2.012 -0.619
ENSG00000100239 E019 9.799945 0.0101676038 1.442184e-03 5.446920e-03 22 50388986 50389033 48 + 1.224 0.859 -1.338
ENSG00000100239 E020 17.125830 0.0121813596 5.183033e-05 2.908501e-04 22 50389034 50389111 78 + 1.458 1.062 -1.394
ENSG00000100239 E021 9.232361 0.0191354708 4.311140e-01 5.737093e-01 22 50391867 50392015 149 + 1.032 0.923 -0.405
ENSG00000100239 E022 6.294701 0.0028299148 2.674522e-02 6.546254e-02 22 50393750 50393799 50 + 1.010 0.723 -1.104
ENSG00000100239 E023 327.562681 0.0067732998 6.807641e-03 2.072319e-02 22 50393893 50394135 243 + 2.533 2.409 -0.414
ENSG00000100239 E024 176.797580 0.0089831037 3.224617e-02 7.632535e-02 22 50406689 50406734 46 + 2.262 2.143 -0.397
ENSG00000100239 E025 292.334016 0.0057886239 5.487231e-02 1.177735e-01 22 50406735 50406875 141 + 2.456 2.369 -0.289
ENSG00000100239 E026 268.500802 0.0059953304 2.599514e-01 3.974386e-01 22 50414552 50414689 138 + 2.394 2.341 -0.178
ENSG00000100239 E027 203.616584 0.0021913961 1.089090e-02 3.090547e-02 22 50416092 50416157 66 + 2.305 2.208 -0.323
ENSG00000100239 E028 250.802505 0.0022798060 9.966642e-01 1.000000e+00 22 50418867 50418979 113 + 2.328 2.321 -0.021
ENSG00000100239 E029 2.842011 0.0053973942 2.073837e-01 3.353718e-01 22 50418980 50418989 10 + 0.681 0.470 -0.961
ENSG00000100239 E030 10.654555 0.0209413650 4.490616e-01 5.902667e-01 22 50419346 50419348 3 + 0.906 1.004 0.367
ENSG00000100239 E031 262.748613 0.0009706369 4.639032e-02 1.027427e-01 22 50419349 50419441 93 + 2.392 2.328 -0.213
ENSG00000100239 E032 168.708372 0.0011726121 2.500843e-02 6.189121e-02 22 50419442 50419462 21 + 2.217 2.133 -0.282
ENSG00000100239 E033 289.271053 0.0001530071 1.523915e-02 4.102792e-02 22 50422254 50422380 127 + 2.434 2.368 -0.219
ENSG00000100239 E034 299.254453 0.0015362633 5.225477e-01 6.563443e-01 22 50423462 50423604 143 + 2.420 2.394 -0.086
ENSG00000100239 E035 140.093332 0.0003334223 2.309044e-01 3.635561e-01 22 50423605 50423614 10 + 2.107 2.057 -0.167
ENSG00000100239 E036 394.361531 0.0002117493 1.673257e-02 4.434964e-02 22 50431173 50431382 210 + 2.562 2.504 -0.193
ENSG00000100239 E037 241.106859 0.0001708492 3.140106e-01 4.566718e-01 22 50432265 50432329 65 + 2.333 2.298 -0.116
ENSG00000100239 E038 363.520723 0.0001334095 7.885377e-01 8.646180e-01 22 50434966 50435081 116 + 2.495 2.481 -0.047
ENSG00000100239 E039 316.108235 0.0002034942 2.894730e-01 4.301532e-01 22 50436367 50436452 86 + 2.446 2.413 -0.110
ENSG00000100239 E040 23.712507 0.0037262429 6.764850e-14 1.968331e-12 22 50436701 50436987 287 + 1.683 1.117 -1.966
ENSG00000100239 E041 192.423946 0.0002755109 2.319068e-01 3.647280e-01 22 50436988 50437068 81 + 2.239 2.196 -0.146
ENSG00000100239 E042 406.480785 0.0001573511 7.070578e-01 8.050784e-01 22 50437506 50437603 98 + 2.544 2.528 -0.053
ENSG00000100239 E043 359.296000 0.0011913477 9.978045e-01 1.000000e+00 22 50437843 50437900 58 + 2.485 2.478 -0.022
ENSG00000100239 E044 447.623803 0.0010687013 1.217213e-01 2.223912e-01 22 50438174 50438298 125 + 2.551 2.582 0.106
ENSG00000100239 E045 489.678841 0.0018658443 2.713083e-04 1.262926e-03 22 50438599 50438762 164 + 2.539 2.635 0.321
ENSG00000100239 E046 21.729033 0.0012451047 9.367647e-01 9.642470e-01 22 50439698 50439700 3 + 1.301 1.286 -0.051
ENSG00000100239 E047 320.547801 0.0024468764 3.022431e-03 1.033258e-02 22 50439701 50439752 52 + 2.358 2.452 0.313
ENSG00000100239 E048 354.789506 0.0016701443 2.368576e-05 1.444407e-04 22 50439753 50439857 105 + 2.380 2.500 0.402
ENSG00000100239 E049 13.423731 0.1127057287 5.768447e-01 7.022028e-01 22 50439858 50439960 103 + 1.193 1.051 -0.508
ENSG00000100239 E050 318.257739 0.0017628449 5.240000e-07 4.615932e-06 22 50439961 50440049 89 + 2.306 2.458 0.506
ENSG00000100239 E051 9.230582 0.0029124461 5.375167e-01 6.690644e-01 22 50440801 50440821 21 + 0.876 0.945 0.264
ENSG00000100239 E052 337.326424 0.0023064241 6.447550e-10 9.912911e-09 22 50440822 50440955 134 + 2.292 2.492 0.667
ENSG00000100239 E053 268.222127 0.0002686860 7.872574e-20 4.899591e-18 22 50440956 50441026 71 + 2.148 2.400 0.844
ENSG00000100239 E054 15.044955 0.0129308444 2.688293e-01 4.073042e-01 22 50441027 50441074 48 + 1.224 1.099 -0.444
ENSG00000100239 E055 133.914363 0.0085434964 7.959025e-04 3.244982e-03 22 50443087 50443865 779 + 2.191 2.002 -0.634
ENSG00000100239 E056 530.998305 0.0012269233 3.218621e-10 5.212945e-09 22 50443866 50444117 252 + 2.530 2.680 0.502
ENSG00000100239 E057 151.008213 0.0022541869 3.276230e-02 7.733074e-02 22 50444199 50444202 4 + 2.042 2.123 0.274
ENSG00000100239 E058 238.137658 0.0005440468 2.806503e-09 3.831677e-08 22 50444203 50444312 110 + 2.162 2.335 0.577
ENSG00000100239 E059 159.490562 0.0002570111 2.920987e-07 2.709952e-06 22 50444313 50444649 337 + 1.989 2.162 0.577
ENSG00000100239 E060 169.437132 0.0025967242 3.330834e-02 7.840565e-02 22 50444650 50445090 441 + 2.094 2.174 0.268