ENSG00000100226

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216044 ENSG00000100226 HEK293_OSMI2_2hA HEK293_TMG_2hB GTPBP1 protein_coding protein_coding 56.93551 79.47582 43.46642 5.510165 0.5191034 -0.8704643 47.764435 73.354636 31.569269 4.6805611 0.6563524 -1.216107 0.81472083 0.92386667 0.7265333 -0.1973333 5.188136e-11 5.927747e-39 FALSE TRUE
ENST00000418601 ENSG00000100226 HEK293_OSMI2_2hA HEK293_TMG_2hB GTPBP1 protein_coding nonsense_mediated_decay 56.93551 79.47582 43.46642 5.510165 0.5191034 -0.8704643 3.376418 1.351282 5.404819 0.1856264 0.2529709 1.991948 0.07023333 0.01683333 0.1242667 0.1074333 5.927747e-39 5.927747e-39 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100226 E001 1.7693146 0.0078088831 1.206519e-01 2.208931e-01 22 38705742 38705817 76 + 0.564 0.341 -1.156
ENSG00000100226 E002 1.6606605 0.0081638203 5.788163e-01 7.038031e-01 22 38705934 38705943 10 + 0.443 0.386 -0.308
ENSG00000100226 E003 1.8058332 0.0081333665 3.431204e-01 4.871809e-01 22 38705944 38705948 5 + 0.507 0.386 -0.630
ENSG00000100226 E004 206.5116553 0.0067124081 2.085681e-11 4.120188e-10 22 38705949 38706117 169 + 2.431 2.191 -0.799
ENSG00000100226 E005 163.7432470 0.0063947101 4.013525e-11 7.564169e-10 22 38706118 38706147 30 + 2.331 2.088 -0.811
ENSG00000100226 E006 0.1451727 0.0430524383 2.262673e-01   22 38706511 38706519 9 + 0.159 0.000 -22.799
ENSG00000100226 E007 0.9911135 0.0122695996 3.551855e-01 4.995607e-01 22 38706520 38706781 262 + 0.367 0.235 -0.893
ENSG00000100226 E008 0.5943067 0.0220066059 7.890116e-02 1.577565e-01 22 38706782 38706856 75 + 0.367 0.093 -2.480
ENSG00000100226 E009 325.2808561 0.0037337115 2.402131e-11 4.705579e-10 22 38708845 38708956 112 + 2.583 2.419 -0.546
ENSG00000100226 E010 559.4952949 0.0016585555 1.748089e-09 2.476779e-08 22 38715907 38716087 181 + 2.763 2.686 -0.254
ENSG00000100226 E011 1.5092574 0.0106332257 2.125178e-01 3.415208e-01 22 38716088 38716240 153 + 0.159 0.427 1.917
ENSG00000100226 E012 877.3293836 0.0013337739 3.497108e-08 3.885728e-07 22 38716652 38717000 349 + 2.937 2.893 -0.144
ENSG00000100226 E013 505.6030416 0.0030388127 2.113507e-05 1.303310e-04 22 38721742 38721865 124 + 2.709 2.650 -0.196
ENSG00000100226 E014 517.7288156 0.0022201890 9.037692e-06 6.070426e-05 22 38724297 38724411 115 + 2.713 2.663 -0.167
ENSG00000100226 E015 2.0199046 0.0072199427 1.917817e-01 3.159922e-01 22 38725176 38725440 265 + 0.564 0.386 -0.892
ENSG00000100226 E016 1.4329718 0.0242631255 6.870839e-01 7.895011e-01 22 38725807 38726005 199 + 0.276 0.387 0.696
ENSG00000100226 E017 585.3629975 0.0013110969 6.272083e-05 3.447935e-04 22 38726006 38726150 145 + 2.745 2.725 -0.068
ENSG00000100226 E018 340.7483780 0.0001786429 8.623675e-03 2.534604e-02 22 38726258 38726305 48 + 2.487 2.498 0.039
ENSG00000100226 E019 478.5519853 0.0003405893 1.132340e-01 2.102421e-01 22 38726306 38726440 135 + 2.615 2.653 0.125
ENSG00000100226 E020 481.7855342 0.0013286562 3.105547e-03 1.057684e-02 22 38727213 38727348 136 + 2.647 2.645 -0.003
ENSG00000100226 E021 586.7719888 0.0003848565 1.055149e-05 6.976888e-05 22 38727983 38728161 179 + 2.737 2.727 -0.033
ENSG00000100226 E022 12.9229632 0.0191469225 9.764028e-01 9.892484e-01 22 38728256 38729461 1206 + 1.049 1.118 0.249
ENSG00000100226 E023 531.1151742 0.0001236673 9.211232e-01 9.542284e-01 22 38729462 38729662 201 + 2.638 2.707 0.230
ENSG00000100226 E024 178.3489353 0.0002312801 2.099439e-01 3.384654e-01 22 38730612 38730612 1 + 2.141 2.246 0.349
ENSG00000100226 E025 241.8588470 0.0007402050 1.188602e-01 2.183154e-01 22 38730613 38730659 47 + 2.266 2.379 0.375
ENSG00000100226 E026 457.5094911 0.0001240311 9.239922e-03 2.688655e-02 22 38730660 38730881 222 + 2.540 2.656 0.387
ENSG00000100226 E027 4456.3698492 0.0056734817 4.634354e-13 1.200553e-11 22 38730882 38733587 2706 + 3.425 3.678 0.839
ENSG00000100226 E028 19.2124755 0.0207223749 1.823307e-04 8.879202e-04 22 38734150 38734232 83 + 1.469 1.149 -1.119
ENSG00000100226 E029 12.1216502 0.0029285781 5.549541e-06 3.910377e-05 22 38734233 38734323 91 + 1.303 0.925 -1.364
ENSG00000100226 E030 9.7033203 0.0074252910 4.785298e-02 1.053613e-01 22 38734324 38734324 1 + 1.098 0.937 -0.592
ENSG00000100226 E031 16.7889727 0.0010877276 6.487239e-05 3.552707e-04 22 38734325 38734397 73 + 1.381 1.112 -0.949
ENSG00000100226 E032 9.2260366 0.0032039617 1.614965e-03 6.008215e-03 22 38735174 38735310 137 + 1.142 0.858 -1.049
ENSG00000100226 E033 27.2078000 0.0053705960 2.152446e-06 1.662209e-05 22 38736029 38736256 228 + 1.588 1.300 -0.994
ENSG00000100226 E034 31.8698024 0.0077126702 1.032438e-06 8.538909e-06 22 38737951 38738299 349 + 1.661 1.363 -1.021