ENSG00000100209

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000216027 ENSG00000100209 HEK293_OSMI2_2hA HEK293_TMG_2hB HSCB protein_coding protein_coding 14.81646 15.1323 19.35537 1.656405 0.3101966 0.3548946 8.1713378 7.4424959 11.7228549 1.2777113 0.8185685 0.6547585 0.5310208 0.48563333 0.60500000 0.119366667 0.177575120 2.7168e-05 FALSE  
ENST00000398941 ENSG00000100209 HEK293_OSMI2_2hA HEK293_TMG_2hB HSCB protein_coding protein_coding 14.81646 15.1323 19.35537 1.656405 0.3101966 0.3548946 1.5574682 2.0989668 0.8891344 0.1526311 0.1524494 -1.2299277 0.1141167 0.14070000 0.04573333 -0.094966667 0.000027168 2.7168e-05 FALSE  
ENST00000420442 ENSG00000100209 HEK293_OSMI2_2hA HEK293_TMG_2hB HSCB protein_coding nonsense_mediated_decay 14.81646 15.1323 19.35537 1.656405 0.3101966 0.3548946 1.2887003 0.9646331 1.9275984 0.5399654 0.9999528 0.9913385 0.0912625 0.06560000 0.10130000 0.035700000 0.943405821 2.7168e-05 TRUE  
ENST00000483861 ENSG00000100209 HEK293_OSMI2_2hA HEK293_TMG_2hB HSCB protein_coding processed_transcript 14.81646 15.1323 19.35537 1.656405 0.3101966 0.3548946 0.9861942 0.9224532 1.0315742 0.3241252 0.2712552 0.1596624 0.0695375 0.06283333 0.05376667 -0.009066667 0.976096605 2.7168e-05    
MSTRG.21884.1 ENSG00000100209 HEK293_OSMI2_2hA HEK293_TMG_2hB HSCB protein_coding   14.81646 15.1323 19.35537 1.656405 0.3101966 0.3548946 2.3079703 2.9572043 2.9185322 0.6118693 0.2790536 -0.0189265 0.1560167 0.19180000 0.15073333 -0.041066667 0.482568107 2.7168e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100209 E001 2.7165241 0.0201756016 0.1157190192 0.213843763 22 28742000 28742038 39 + 0.694 0.437 -1.183
ENSG00000100209 E002 2.8982285 0.0337185948 0.2213109772 0.352001031 22 28742039 28742041 3 + 0.694 0.489 -0.921
ENSG00000100209 E003 7.0312650 0.0059789137 0.2371671388 0.370900580 22 28742042 28742054 13 + 0.978 0.840 -0.523
ENSG00000100209 E004 10.6955783 0.0021107131 0.0062911604 0.019377015 22 28742055 28742060 6 + 1.193 0.920 -0.994
ENSG00000100209 E005 51.2132083 0.0004741009 0.9123357300 0.948440279 22 28742061 28742150 90 + 1.719 1.729 0.035
ENSG00000100209 E006 136.1660898 0.0002796711 0.0025931457 0.009044715 22 28742151 28742331 181 + 2.096 2.186 0.303
ENSG00000100209 E007 2.8817546 0.0053384525 0.5034056471 0.639371746 22 28742679 28742700 22 + 0.638 0.537 -0.453
ENSG00000100209 E008 4.9414146 0.0033039563 0.3695684072 0.513963012 22 28742701 28742728 28 + 0.831 0.715 -0.464
ENSG00000100209 E009 90.0698419 0.0025668221 0.5050956266 0.640925204 22 28743882 28743923 42 + 1.978 1.957 -0.073
ENSG00000100209 E010 101.6966282 0.0022946394 0.7679528972 0.850063528 22 28743924 28743978 55 + 2.009 2.023 0.045
ENSG00000100209 E011 107.4367607 0.0018492109 0.7055936326 0.803924791 22 28744615 28744704 90 + 2.046 2.035 -0.037
ENSG00000100209 E012 13.3501515 0.0013255462 0.9812278265 0.992295408 22 28744705 28744709 5 + 1.157 1.164 0.024
ENSG00000100209 E013 0.6998377 0.0182049564 0.8939239732 0.936174812 22 28745256 28745543 288 + 0.206 0.230 0.200
ENSG00000100209 E014 111.4250751 0.0003530264 0.0005117749 0.002203755 22 28745864 28746008 145 + 2.106 2.000 -0.356
ENSG00000100209 E015 102.9873409 0.0032637356 0.4472812265 0.588678064 22 28751241 28751288 48 + 2.003 2.034 0.106
ENSG00000100209 E016 193.9069900 0.0031058661 0.2418251019 0.376343444 22 28757078 28757515 438 + 2.274 2.312 0.126