ENSG00000100151

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356976 ENSG00000100151 HEK293_OSMI2_2hA HEK293_TMG_2hB PICK1 protein_coding protein_coding 62.07281 102.4063 35.96828 5.833006 0.912395 -1.509247 32.193956 61.7904663 13.243245 3.3173211 0.3719819 -2.2212721 0.47645417 0.60363333 0.36816667 -0.23546667 2.348144e-42 2.348144e-42 FALSE TRUE
ENST00000437453 ENSG00000100151 HEK293_OSMI2_2hA HEK293_TMG_2hB PICK1 protein_coding protein_coding 62.07281 102.4063 35.96828 5.833006 0.912395 -1.509247 9.982277 15.8235756 6.672021 2.0050322 0.7963640 -1.2446307 0.16565833 0.15353333 0.18516667 0.03163333 5.950751e-01 2.348144e-42 FALSE FALSE
ENST00000484021 ENSG00000100151 HEK293_OSMI2_2hA HEK293_TMG_2hB PICK1 protein_coding retained_intron 62.07281 102.4063 35.96828 5.833006 0.912395 -1.509247 3.975351 3.6061582 3.005308 0.4827637 0.2195304 -0.2621524 0.07247500 0.03530000 0.08386667 0.04856667 5.980600e-04 2.348144e-42 TRUE TRUE
MSTRG.22098.3 ENSG00000100151 HEK293_OSMI2_2hA HEK293_TMG_2hB PICK1 protein_coding   62.07281 102.4063 35.96828 5.833006 0.912395 -1.509247 3.724121 8.3224288 2.026178 0.7380958 0.8076578 -2.0328735 0.05437500 0.08113333 0.05656667 -0.02456667 5.267157e-01 2.348144e-42 TRUE TRUE
MSTRG.22098.9 ENSG00000100151 HEK293_OSMI2_2hA HEK293_TMG_2hB PICK1 protein_coding   62.07281 102.4063 35.96828 5.833006 0.912395 -1.509247 1.524243 0.8513526 2.728328 0.2404389 0.5522774 1.6686193 0.03618333 0.00860000 0.07556667 0.06696667 6.519248e-05 2.348144e-42 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100151 E001 0.4428904 0.4215485416 1.000000e+00 1.000000e+00 22 38056311 38056598 288 + 0.000 0.134 8.998
ENSG00000100151 E002 1.3964663 0.2368437045 3.823775e-01 5.266008e-01 22 38057171 38057171 1 + 0.456 0.273 -1.083
ENSG00000100151 E003 5.3057617 0.0031940270 1.735726e-01 2.928252e-01 22 38057172 38057199 28 + 0.856 0.663 -0.776
ENSG00000100151 E004 8.2261468 0.0034589888 2.265471e-01 3.582855e-01 22 38057200 38057227 28 + 0.984 0.835 -0.566
ENSG00000100151 E005 10.4081603 0.0030136477 2.279554e-01 3.599916e-01 22 38057228 38057254 27 + 1.060 0.924 -0.507
ENSG00000100151 E006 9.7729669 0.0022677117 7.698657e-01 8.514180e-01 22 38057255 38057264 10 + 0.955 0.923 -0.120
ENSG00000100151 E007 29.0227023 0.0125419000 7.415690e-01 8.306950e-01 22 38057265 38057394 130 + 1.342 1.378 0.124
ENSG00000100151 E008 27.5926661 0.0278660065 9.809253e-01 9.920795e-01 22 38057395 38057403 9 + 1.355 1.355 0.000
ENSG00000100151 E009 25.8504225 0.0252020152 9.457328e-01 9.699461e-01 22 38057404 38057406 3 + 1.330 1.328 -0.009
ENSG00000100151 E010 174.7933076 0.0031454086 3.864498e-02 8.852482e-02 22 38057407 38057436 30 + 2.200 2.121 -0.264
ENSG00000100151 E011 197.1645768 0.0046062882 5.969072e-03 1.852532e-02 22 38057437 38057482 46 + 2.277 2.164 -0.376
ENSG00000100151 E012 195.8624523 0.0057333726 8.390908e-03 2.476719e-02 22 38057483 38057489 7 + 2.275 2.161 -0.384
ENSG00000100151 E013 209.0557606 0.0077699380 3.142887e-03 1.068593e-02 22 38057490 38057587 98 + 2.324 2.183 -0.470
ENSG00000100151 E014 0.1472490 0.0428370155 1.221273e-01   22 38057653 38057655 3 + 0.209 0.000 -13.892
ENSG00000100151 E015 8.7336223 0.0020663210 9.467624e-04 3.777459e-03 22 38057656 38057752 97 + 1.164 0.789 -1.399
ENSG00000100151 E016 394.0680057 0.0005877846 2.580914e-06 1.960648e-05 22 38057753 38057819 67 + 2.568 2.464 -0.347
ENSG00000100151 E017 308.0819685 0.0002079433 1.702769e-06 1.345111e-05 22 38057820 38057850 31 + 2.465 2.354 -0.369
ENSG00000100151 E018 0.5922303 0.0179901240 2.403720e-02 5.989287e-02 22 38057851 38058158 308 + 0.455 0.069 -3.433
ENSG00000100151 E019 497.4361527 0.0001300316 2.204038e-04 1.051124e-03 22 38059234 38059345 112 + 2.638 2.573 -0.218
ENSG00000100151 E020 530.2006567 0.0001721381 8.334928e-03 2.462996e-02 22 38065002 38065112 111 + 2.650 2.605 -0.148
ENSG00000100151 E021 255.5514715 0.0001782183 3.744450e-01 5.188522e-01 22 38065113 38065130 18 + 2.312 2.293 -0.064
ENSG00000100151 E022 3.6825397 0.0238529834 1.406855e-01 2.489603e-01 22 38065131 38065226 96 + 0.774 0.532 -1.039
ENSG00000100151 E023 6.1621216 0.0222924891 9.615763e-01 9.797916e-01 22 38067477 38067703 227 + 0.774 0.774 0.000
ENSG00000100151 E024 404.6542555 0.0003891331 2.091696e-01 3.375316e-01 22 38067704 38067770 67 + 2.469 2.504 0.119
ENSG00000100151 E025 11.6907216 0.0014874359 2.722288e-08 3.090050e-07 22 38067771 38068071 301 + 1.377 0.835 -1.968
ENSG00000100151 E026 7.0188249 0.0035152909 2.444176e-03 8.594903e-03 22 38068072 38068114 43 + 1.083 0.709 -1.431
ENSG00000100151 E027 437.9155366 0.0001228896 4.626983e-03 1.489420e-02 22 38069033 38069122 90 + 2.476 2.543 0.222
ENSG00000100151 E028 294.8725607 0.0001829312 3.058191e-02 7.311063e-02 22 38070838 38070891 54 + 2.307 2.370 0.210
ENSG00000100151 E029 368.9106883 0.0001510640 1.605284e-01 2.758349e-01 22 38071682 38071744 63 + 2.426 2.465 0.127
ENSG00000100151 E030 13.7346284 0.0230399581 2.404964e-02 5.991522e-02 22 38071745 38072007 263 + 1.262 1.005 -0.924
ENSG00000100151 E031 470.8195164 0.0013196985 4.211721e-02 9.493925e-02 22 38072477 38072610 134 + 2.513 2.574 0.204
ENSG00000100151 E032 478.6174433 0.0002451533 2.148403e-02 5.461221e-02 22 38073000 38073092 93 + 2.524 2.579 0.181
ENSG00000100151 E033 364.9917825 0.0003119568 2.177129e-03 7.770941e-03 22 38073773 38073823 51 + 2.384 2.466 0.273
ENSG00000100151 E034 91.7089234 0.0013575272 1.642487e-18 8.809857e-17 22 38073824 38074306 483 + 2.126 1.757 -1.242
ENSG00000100151 E035 587.1244388 0.0021909377 6.307926e-04 2.646596e-03 22 38074307 38074451 145 + 2.571 2.678 0.357
ENSG00000100151 E036 740.0533921 0.0016466475 1.599526e-03 5.959789e-03 22 38074864 38075119 256 + 2.690 2.776 0.287
ENSG00000100151 E037 702.9547485 0.0016852325 6.641303e-10 1.018435e-08 22 38075120 38075701 582 + 2.599 2.766 0.556
ENSG00000100151 E038 4.3747154 0.2648151736 2.039030e-02 5.230711e-02 22 38076031 38076109 79 + 0.986 0.482 -2.090
ENSG00000100151 E039 3.9900524 0.0042135925 2.518216e-03 8.817782e-03 22 38077388 38077420 33 + 0.925 0.486 -1.846
ENSG00000100151 E040 6.9093734 0.0025256515 1.000392e-08 1.233621e-07 22 38078182 38078383 202 + 1.247 0.574 -2.601