ENSG00000100109

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000405938 ENSG00000100109 HEK293_OSMI2_2hA HEK293_TMG_2hB TFIP11 protein_coding protein_coding 47.62497 56.99264 46.26904 5.220446 1.336924 -0.3006699 3.709470 3.995861 5.560031 1.0424542 0.4817841 0.4755731 0.07887083 0.07416667 0.1202333 0.04606667 3.765588e-01 5.658137e-07 FALSE TRUE
ENST00000407148 ENSG00000100109 HEK293_OSMI2_2hA HEK293_TMG_2hB TFIP11 protein_coding protein_coding 47.62497 56.99264 46.26904 5.220446 1.336924 -0.3006699 22.427814 28.318861 17.674164 2.5998690 0.1038734 -0.6798146 0.46422500 0.49686667 0.3825333 -0.11433333 5.658137e-07 5.658137e-07 FALSE TRUE
ENST00000407431 ENSG00000100109 HEK293_OSMI2_2hA HEK293_TMG_2hB TFIP11 protein_coding protein_coding 47.62497 56.99264 46.26904 5.220446 1.336924 -0.3006699 6.743753 11.422958 5.765940 2.5237873 0.1706266 -0.9850712 0.13601250 0.19693333 0.1246000 -0.07233333 1.748455e-01 5.658137e-07 FALSE TRUE
ENST00000407690 ENSG00000100109 HEK293_OSMI2_2hA HEK293_TMG_2hB TFIP11 protein_coding protein_coding 47.62497 56.99264 46.26904 5.220446 1.336924 -0.3006699 3.947436 4.433368 3.227912 0.4880318 0.3907564 -0.4565900 0.08780833 0.07760000 0.0703000 -0.00730000 8.261784e-01 5.658137e-07 FALSE TRUE
ENST00000479489 ENSG00000100109 HEK293_OSMI2_2hA HEK293_TMG_2hB TFIP11 protein_coding retained_intron 47.62497 56.99264 46.26904 5.220446 1.336924 -0.3006699 9.130151 7.633043 12.033148 1.2887709 0.9683157 0.6559935 0.19495833 0.13326667 0.2594667 0.12620000 3.377508e-04 5.658137e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100109 E001 1.1686652 0.1226808693 8.853415e-01 9.306697e-01 22 26491225 26491239 15 - 0.343 0.314 -0.179
ENSG00000100109 E002 47.2873548 0.0016361163 3.486605e-01 4.928931e-01 22 26491240 26491926 687 - 1.688 1.661 -0.092
ENSG00000100109 E003 67.6974047 0.0117988503 7.105087e-02 1.450878e-01 22 26491927 26491985 59 - 1.715 1.874 0.537
ENSG00000100109 E004 731.9940665 0.0027210337 7.622532e-07 6.497484e-06 22 26491986 26492368 383 - 2.739 2.897 0.525
ENSG00000100109 E005 539.3053226 0.0029841669 7.553743e-05 4.068211e-04 22 26494139 26494304 166 - 2.620 2.759 0.465
ENSG00000100109 E006 1.9165636 0.0074341162 1.677126e-01 2.852199e-01 22 26494305 26494619 315 - 0.581 0.365 -1.089
ENSG00000100109 E007 417.0935445 0.0023195221 8.980023e-07 7.530454e-06 22 26494797 26494939 143 - 2.491 2.656 0.548
ENSG00000100109 E008 528.0530515 0.0029257927 7.432276e-04 3.054809e-03 22 26496073 26496316 244 - 2.624 2.744 0.400
ENSG00000100109 E009 412.0980404 0.0018067291 4.829905e-03 1.545757e-02 22 26496721 26496889 169 - 2.534 2.630 0.320
ENSG00000100109 E010 0.9974562 0.0126943158 5.676824e-01 6.944482e-01 22 26498703 26498868 166 - 0.343 0.253 -0.603
ENSG00000100109 E011 321.3219591 0.0002060789 2.802745e-02 6.806717e-02 22 26498869 26498975 107 - 2.446 2.516 0.236
ENSG00000100109 E012 486.9382528 0.0010924070 4.535251e-01 5.942741e-01 22 26499104 26499413 310 - 2.646 2.686 0.131
ENSG00000100109 E013 308.6969043 0.0014652486 3.878646e-01 5.319996e-01 22 26499414 26499536 123 - 2.445 2.493 0.159
ENSG00000100109 E014 290.9313182 0.0001741838 4.325339e-01 5.749707e-01 22 26499537 26499631 95 - 2.423 2.465 0.139
ENSG00000100109 E015 381.3366693 0.0006431956 7.914724e-01 8.666088e-01 22 26501900 26502035 136 - 2.554 2.571 0.055
ENSG00000100109 E016 210.6846379 0.0010440138 9.882785e-01 9.967440e-01 22 26502036 26502052 17 - 2.293 2.315 0.074
ENSG00000100109 E017 1.3682388 0.0097790178 4.297386e-01 5.724137e-01 22 26502053 26502094 42 - 0.256 0.412 0.981
ENSG00000100109 E018 379.9049098 0.0010909945 1.525813e-01 2.651836e-01 22 26503666 26503793 128 - 2.572 2.559 -0.041
ENSG00000100109 E019 0.6266857 0.0172671820 6.381365e-01 7.518516e-01 22 26505910 26506302 393 - 0.256 0.184 -0.604
ENSG00000100109 E020 417.2500709 0.0016357215 2.401111e-04 1.133788e-03 22 26506303 26506459 157 - 2.650 2.577 -0.241
ENSG00000100109 E021 9.0812262 0.0473184349 4.597470e-01 5.998456e-01 22 26506460 26506672 213 - 1.042 0.942 -0.369
ENSG00000100109 E022 4.1234581 0.0062114504 8.341597e-02 1.649142e-01 22 26506673 26506737 65 - 0.821 0.592 -0.950
ENSG00000100109 E023 3.1603580 0.0059144608 5.485667e-02 1.177479e-01 22 26506738 26506773 36 - 0.764 0.493 -1.189
ENSG00000100109 E024 1.5717156 0.0298935530 4.730456e-01 6.120590e-01 22 26506774 26506774 1 - 0.478 0.365 -0.606
ENSG00000100109 E025 339.6300049 0.0009164397 1.562464e-07 1.529026e-06 22 26506775 26506873 99 - 2.579 2.477 -0.339
ENSG00000100109 E026 184.4686944 0.0002220235 3.567984e-06 2.626555e-05 22 26506874 26506877 4 - 2.315 2.216 -0.330
ENSG00000100109 E027 234.6166237 0.0002228335 8.321825e-05 4.432402e-04 22 26506878 26506928 51 - 2.401 2.331 -0.232
ENSG00000100109 E028 290.6288796 0.0001581499 2.125409e-09 2.962421e-08 22 26510064 26510144 81 - 2.514 2.411 -0.340
ENSG00000100109 E029 316.0672296 0.0001726466 4.547420e-10 7.176136e-09 22 26510145 26510281 137 - 2.550 2.447 -0.342
ENSG00000100109 E030 158.4698087 0.0011660050 5.751542e-03 1.795936e-02 22 26510617 26510667 51 - 2.229 2.163 -0.219
ENSG00000100109 E031 126.3596700 0.0024701873 7.906438e-04 3.225833e-03 22 26510668 26510692 25 - 2.157 2.049 -0.359
ENSG00000100109 E032 108.6771413 0.0024930479 2.792360e-04 1.295278e-03 22 26510693 26510702 10 - 2.102 1.977 -0.421
ENSG00000100109 E033 0.4418608 0.0259882890 3.422018e-02 8.018343e-02 22 26510703 26510707 5 - 0.343 0.000 -10.447
ENSG00000100109 E034 8.2480636 0.0023065680 1.527562e-03 5.726338e-03 22 26511119 26511153 35 - 1.128 0.798 -1.235
ENSG00000100109 E035 6.6625417 0.0025945714 2.414191e-02 6.010406e-02 22 26511154 26511195 42 - 1.010 0.760 -0.956
ENSG00000100109 E036 1.4662969 0.0804382102 7.142215e-01 8.105037e-01 22 26511196 26511317 122 - 0.416 0.365 -0.282
ENSG00000100109 E037 3.6806669 0.0054524261 1.340393e-01 2.397612e-01 22 26511689 26512098 410 - 0.764 0.562 -0.865
ENSG00000100109 E038 194.2353646 0.0008434654 3.291039e-07 3.019407e-06 22 26512099 26512175 77 - 2.349 2.225 -0.414
ENSG00000100109 E039 11.0134919 0.0076277821 9.304082e-01 9.602179e-01 22 26512176 26512377 202 - 1.042 1.073 0.110
ENSG00000100109 E040 131.4907009 0.0039253055 8.069780e-04 3.283435e-03 22 26512394 26512505 112 - 2.180 2.053 -0.424