ENSG00000100105

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000215919 ENSG00000100105 HEK293_OSMI2_2hA HEK293_TMG_2hB PATZ1 protein_coding protein_coding 39.76651 56.19616 34.37863 3.264676 1.291876 -0.7087968 7.655206 10.766290 5.85583231 1.3947666 0.24709210 -0.8774528 0.18587083 0.1901000 0.17083333 -0.01926667 0.7467889401 0.0001634509 FALSE TRUE
ENST00000351933 ENSG00000100105 HEK293_OSMI2_2hA HEK293_TMG_2hB PATZ1 protein_coding protein_coding 39.76651 56.19616 34.37863 3.264676 1.291876 -0.7087968 17.934269 26.692744 15.56835000 0.9049149 0.45455596 -0.7774456 0.45433750 0.4764333 0.45320000 -0.02323333 0.6635020680 0.0001634509 FALSE TRUE
ENST00000405309 ENSG00000100105 HEK293_OSMI2_2hA HEK293_TMG_2hB PATZ1 protein_coding protein_coding 39.76651 56.19616 34.37863 3.264676 1.291876 -0.7087968 2.587332 2.990351 2.51143579 0.1643304 0.12185297 -0.2508859 0.06571250 0.0535000 0.07346667 0.01996667 0.2051233200 0.0001634509 FALSE TRUE
ENST00000465287 ENSG00000100105 HEK293_OSMI2_2hA HEK293_TMG_2hB PATZ1 protein_coding retained_intron 39.76651 56.19616 34.37863 3.264676 1.291876 -0.7087968 3.068067 7.154845 0.06937784 1.1963365 0.06937784 -6.4960553 0.06872917 0.1302000 0.00210000 -0.12810000 0.0001634509 0.0001634509   FALSE
MSTRG.21964.5 ENSG00000100105 HEK293_OSMI2_2hA HEK293_TMG_2hB PATZ1 protein_coding   39.76651 56.19616 34.37863 3.264676 1.291876 -0.7087968 6.662926 5.804690 8.60682509 1.9254356 1.14350304 0.5674541 0.17888333 0.1001333 0.24876667 0.14863333 0.0424781690 0.0001634509 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100105 E001 0.0000000       22 31308770 31308810 41 -      
ENSG00000100105 E002 0.7414659 0.8684611162 5.001900e-01 6.364524e-01 22 31325804 31325808 5 - 0.001 0.307 9.580
ENSG00000100105 E003 341.3960901 0.0113058916 2.839532e-04 1.314616e-03 22 31325809 31326080 272 - 2.347 2.540 0.643
ENSG00000100105 E004 994.9158211 0.0012252468 5.114957e-05 2.875325e-04 22 31326081 31326826 746 - 2.909 2.972 0.208
ENSG00000100105 E005 666.8476135 0.0008543653 7.628538e-04 3.124832e-03 22 31326827 31327309 483 - 2.831 2.757 -0.243
ENSG00000100105 E006 40.3881006 0.0005391511 4.391522e-03 1.424151e-02 22 31328787 31328859 73 - 1.690 1.517 -0.589
ENSG00000100105 E007 17.9198348 0.0021776571 6.657560e-01 7.733868e-01 22 31328860 31328924 65 - 1.260 1.212 -0.173
ENSG00000100105 E008 2.4398832 0.0096876117 9.054402e-04 3.633031e-03 22 31335418 31335691 274 - 0.818 0.281 -2.618
ENSG00000100105 E009 408.3352007 0.0001772493 2.833920e-15 1.011450e-13 22 31335692 31335863 172 - 2.672 2.515 -0.520
ENSG00000100105 E010 561.3576029 0.0005986934 2.539317e-49 1.475663e-46 22 31340677 31341683 1007 - 2.481 2.772 0.968
ENSG00000100105 E011 375.5596402 0.0001887784 1.089040e-02 3.090451e-02 22 31342897 31342960 64 - 2.574 2.513 -0.205
ENSG00000100105 E012 11.0458138 0.0016087594 1.823035e-03 6.673399e-03 22 31342961 31343591 631 - 0.752 1.116 1.375
ENSG00000100105 E013 3.3140569 0.0166861953 1.202320e-01 2.203267e-01 22 31343944 31344003 60 - 0.380 0.647 1.298
ENSG00000100105 E014 1510.6054315 0.0034106601 1.087032e-05 7.162206e-05 22 31344332 31346400 2069 - 3.207 3.104 -0.343