ENSG00000100083

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343632 ENSG00000100083 HEK293_OSMI2_2hA HEK293_TMG_2hB GGA1 protein_coding protein_coding 58.04129 78.33868 39.28384 3.074744 0.9149233 -0.9956057 31.528541 47.814864 16.584769 3.5000948 0.2584275 -1.5270323 0.52723750 0.60880000 0.42273333 -0.18606667 1.873120e-05 2.936569e-09 FALSE TRUE
ENST00000423024 ENSG00000100083 HEK293_OSMI2_2hA HEK293_TMG_2hB GGA1 protein_coding protein_coding 58.04129 78.33868 39.28384 3.074744 0.9149233 -0.9956057 1.992936 1.223594 3.377256 0.2749463 0.4048277 1.4572499 0.04014583 0.01543333 0.08606667 0.07063333 2.936569e-09 2.936569e-09 FALSE FALSE
ENST00000460957 ENSG00000100083 HEK293_OSMI2_2hA HEK293_TMG_2hB GGA1 protein_coding retained_intron 58.04129 78.33868 39.28384 3.074744 0.9149233 -0.9956057 3.572975 6.961838 1.403347 2.0006297 0.1706483 -2.3024231 0.05371250 0.09090000 0.03556667 -0.05533333 1.159190e-01 2.936569e-09   FALSE
ENST00000489772 ENSG00000100083 HEK293_OSMI2_2hA HEK293_TMG_2hB GGA1 protein_coding retained_intron 58.04129 78.33868 39.28384 3.074744 0.9149233 -0.9956057 4.887449 3.849293 4.411137 0.6334969 0.1121380 0.1960808 0.09296667 0.04863333 0.11230000 0.06366667 9.182296e-06 2.936569e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100083 E001 0.0000000       22 37608228 37608269 42 +      
ENSG00000100083 E002 0.0000000       22 37608372 37608384 13 +      
ENSG00000100083 E003 14.4718224 0.0012645198 1.857849e-03 6.782230e-03 22 37608385 37608517 133 + 1.310 1.048 -0.932
ENSG00000100083 E004 28.0965238 0.0007152625 1.202519e-02 3.359141e-02 22 37608518 37608599 82 + 1.507 1.354 -0.529
ENSG00000100083 E005 31.5973947 0.0006799591 6.787469e-02 1.398425e-01 22 37608600 37608724 125 + 1.521 1.420 -0.345
ENSG00000100083 E006 14.1760501 0.0023055853 2.742683e-02 6.686023e-02 22 37608725 37608829 105 + 1.252 1.064 -0.670
ENSG00000100083 E007 1.5791897 0.0210388049 3.029771e-01 4.449018e-01 22 37608830 37608833 4 + 0.483 0.310 -0.972
ENSG00000100083 E008 1.5791897 0.0210388049 3.029771e-01 4.449018e-01 22 37608834 37608834 1 + 0.483 0.310 -0.972
ENSG00000100083 E009 15.2441383 0.0276895690 3.577272e-01 5.021439e-01 22 37608835 37608844 10 + 1.212 1.126 -0.308
ENSG00000100083 E010 141.5577006 0.0011603827 5.820663e-01 7.064922e-01 22 37608845 37608903 59 + 2.084 2.088 0.012
ENSG00000100083 E011 0.2965864 0.2502224747 6.953644e-01   22 37608935 37608947 13 + 0.000 0.148 13.961
ENSG00000100083 E012 0.2965864 0.2502224747 6.953644e-01   22 37608948 37608959 12 + 0.000 0.148 13.961
ENSG00000100083 E013 0.5921286 0.3966081433 1.000000e+00 1.000000e+00 22 37608960 37608976 17 + 0.179 0.202 0.215
ENSG00000100083 E014 0.5921286 0.3966081433 1.000000e+00 1.000000e+00 22 37608977 37608983 7 + 0.179 0.202 0.215
ENSG00000100083 E015 1.9593258 0.1296531954 3.992979e-02 9.090693e-02 22 37608984 37609039 56 + 0.706 0.304 -2.012
ENSG00000100083 E016 2.8000829 0.0483914551 9.123956e-03 2.659370e-02 22 37609040 37609048 9 + 0.821 0.388 -1.959
ENSG00000100083 E017 12.7241029 0.0211632645 4.989128e-02 1.089778e-01 22 37609049 37609059 11 + 1.226 1.022 -0.732
ENSG00000100083 E018 14.3784312 0.0138761703 1.474461e-01 2.582178e-01 22 37609060 37609065 6 + 1.226 1.094 -0.472
ENSG00000100083 E019 26.7280605 0.0063907280 1.062268e-01 1.999656e-01 22 37609066 37609154 89 + 1.464 1.357 -0.369
ENSG00000100083 E020 22.7134745 0.0008160890 5.149864e-04 2.215419e-03 22 37609155 37609356 202 + 1.479 1.240 -0.828
ENSG00000100083 E021 14.3132117 0.0015899358 1.920105e-03 6.977904e-03 22 37610142 37610486 345 + 1.310 1.048 -0.933
ENSG00000100083 E022 8.4286892 0.0415800891 7.148567e-01 8.109332e-01 22 37610577 37610699 123 + 0.853 0.932 0.300
ENSG00000100083 E023 23.6117216 0.0007906797 5.942644e-02 1.256561e-01 22 37612536 37613023 488 + 1.415 1.294 -0.422
ENSG00000100083 E024 12.2421686 0.0075337090 4.265729e-01 5.693861e-01 22 37613024 37613032 9 + 1.105 1.041 -0.234
ENSG00000100083 E025 20.2978616 0.0009034860 1.540758e-01 2.672147e-01 22 37613033 37613118 86 + 1.331 1.235 -0.335
ENSG00000100083 E026 21.0343048 0.0184531014 2.422985e-01 3.768882e-01 22 37613119 37613191 73 + 1.341 1.248 -0.326
ENSG00000100083 E027 4.3146628 0.0075663399 4.595162e-01 5.996361e-01 22 37613970 37614032 63 + 0.748 0.656 -0.383
ENSG00000100083 E028 6.0358004 0.0028157419 7.823228e-01 8.602381e-01 22 37614133 37614189 57 + 0.748 0.806 0.232
ENSG00000100083 E029 165.9062331 0.0010845057 2.424101e-01 3.770010e-01 22 37614190 37614193 4 + 2.167 2.151 -0.054
ENSG00000100083 E030 266.2347812 0.0029936643 5.380574e-02 1.159190e-01 22 37614194 37614274 81 + 2.393 2.351 -0.140
ENSG00000100083 E031 265.2329043 0.0014777147 4.528621e-02 1.007171e-01 22 37616922 37616997 76 + 2.388 2.353 -0.119
ENSG00000100083 E032 25.5486099 0.0007924199 3.035408e-10 4.934772e-09 22 37616998 37617048 51 + 1.627 1.214 -1.429
ENSG00000100083 E033 123.7073090 0.0016701713 9.621229e-30 1.586347e-27 22 37617049 37618146 1098 + 2.288 1.889 -1.334
ENSG00000100083 E034 23.9554681 0.0172182806 2.711957e-03 9.409277e-03 22 37618403 37618447 45 + 1.508 1.247 -0.904
ENSG00000100083 E035 333.9570771 0.0002423278 7.428149e-04 3.053443e-03 22 37618448 37618546 99 + 2.498 2.446 -0.170
ENSG00000100083 E036 16.3416634 0.0933494212 4.755832e-01 6.143019e-01 22 37619800 37620237 438 + 1.274 1.142 -0.466
ENSG00000100083 E037 420.2585972 0.0007356701 6.758779e-06 4.671740e-05 22 37620238 37620361 124 + 2.615 2.540 -0.253
ENSG00000100083 E038 249.2944960 0.0062745725 2.439545e-02 6.063314e-02 22 37620813 37620853 41 + 2.391 2.315 -0.250
ENSG00000100083 E039 282.0708209 0.0042294366 6.417673e-02 1.336568e-01 22 37620854 37620913 60 + 2.423 2.377 -0.152
ENSG00000100083 E040 264.2149342 0.0029257921 2.560341e-01 3.929970e-01 22 37621616 37621696 81 + 2.371 2.356 -0.049
ENSG00000100083 E041 280.8621229 0.0021963397 6.430748e-01 7.556975e-01 22 37623327 37623467 141 + 2.355 2.395 0.135
ENSG00000100083 E042 215.2255622 0.0001979322 4.145947e-01 5.580015e-01 22 37623552 37623633 82 + 2.233 2.279 0.154
ENSG00000100083 E043 3.7967184 0.0460593855 2.504753e-01 3.865128e-01 22 37623634 37623828 195 + 0.748 0.571 -0.756
ENSG00000100083 E044 20.3021605 0.0065250679 3.440367e-03 1.155370e-02 22 37623829 37624880 1052 + 1.424 1.193 -0.808
ENSG00000100083 E045 10.1612174 0.0017197137 8.661592e-01 9.178082e-01 22 37624881 37624968 88 + 0.986 0.987 0.006
ENSG00000100083 E046 239.3800460 0.0002055079 3.770898e-05 2.187407e-04 22 37624969 37625076 108 + 2.209 2.346 0.458
ENSG00000100083 E047 310.5075180 0.0034191538 8.632331e-03 2.536733e-02 22 37625797 37625949 153 + 2.332 2.457 0.417
ENSG00000100083 E048 23.5983006 0.0229653306 2.844905e-03 9.809060e-03 22 37625950 37627162 1213 + 1.514 1.237 -0.961
ENSG00000100083 E049 248.6110130 0.0029602842 1.927917e-01 3.172728e-01 22 37629462 37629526 65 + 2.276 2.351 0.251
ENSG00000100083 E050 325.4008241 0.0001913106 1.124394e-02 3.174751e-02 22 37629998 37630162 165 + 2.386 2.468 0.275
ENSG00000100083 E051 92.2158028 0.0025918653 9.833464e-02 1.879877e-01 22 37630163 37630170 8 + 1.825 1.930 0.354
ENSG00000100083 E052 7.9671022 0.0020986107 4.226383e-02 9.520859e-02 22 37630171 37630299 129 + 1.050 0.833 -0.814
ENSG00000100083 E053 3.4353729 0.0046781448 1.066632e-01 2.006297e-01 22 37630588 37630589 2 + 0.748 0.516 -1.008
ENSG00000100083 E054 7.5286671 0.0023124919 3.239482e-03 1.097086e-02 22 37630590 37630667 78 + 1.087 0.761 -1.234
ENSG00000100083 E055 6.2418976 0.0042173878 8.840049e-03 2.588231e-02 22 37630668 37630709 42 + 1.008 0.694 -1.220
ENSG00000100083 E056 8.0573063 0.0493118595 1.128769e-01 2.097476e-01 22 37630710 37630902 193 + 1.051 0.825 -0.848
ENSG00000100083 E057 85.2779966 0.0004729501 6.003764e-02 1.266657e-01 22 37630903 37630906 4 + 1.787 1.896 0.366
ENSG00000100083 E058 313.1261394 0.0001749356 2.400056e-03 8.461587e-03 22 37630907 37631099 193 + 2.357 2.453 0.318
ENSG00000100083 E059 407.5595846 0.0057751505 2.468140e-01 3.822017e-01 22 37631996 37632165 170 + 2.490 2.566 0.254
ENSG00000100083 E060 452.8301419 0.0016667401 7.628249e-02 1.535574e-01 22 37632405 37632515 111 + 2.537 2.611 0.247
ENSG00000100083 E061 1565.6678205 0.0043192636 1.998934e-05 1.240068e-04 22 37632601 37633564 964 + 3.018 3.166 0.492