ENSG00000100075

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000215882 ENSG00000100075 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A1 protein_coding protein_coding 197.3269 388.0087 104.9376 10.83819 1.705511 -1.886457 103.57088 162.0833 70.76870 13.468284 2.147672 -1.195437 0.5345583 0.4166 0.6742000 0.2576000 1.146965e-09 1.146965e-09 FALSE TRUE
ENST00000451283 ENSG00000100075 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A1 protein_coding protein_coding 197.3269 388.0087 104.9376 10.83819 1.705511 -1.886457 66.64604 175.2077 17.88094 7.706578 2.451517 -3.291848 0.3233542 0.4528 0.1709667 -0.2818333 6.355204e-07 1.146965e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000100075 E001 0.0000000       22 19175258 19175320 63 -      
ENSG00000100075 E002 0.0000000       22 19175321 19175375 55 -      
ENSG00000100075 E003 0.1817044 0.0394522511 1.000000e+00   22 19175376 19175460 85 - 0.000 0.066 7.930
ENSG00000100075 E004 0.1817044 0.0394522511 1.000000e+00   22 19175461 19175501 41 - 0.000 0.066 7.909
ENSG00000100075 E005 7.4103648 0.0037547864 1.885445e-01 3.119050e-01 22 19175502 19175580 79 - 0.626 0.840 0.876
ENSG00000100075 E006 119.2814877 0.0043725795 2.447133e-03 8.604343e-03 22 19175581 19175591 11 - 1.812 1.990 0.598
ENSG00000100075 E007 219.9039751 0.0038616599 1.344696e-01 2.403697e-01 22 19175592 19175592 1 - 2.163 2.237 0.248
ENSG00000100075 E008 356.7540559 0.0040413156 4.644477e-05 2.637066e-04 22 19175593 19175609 17 - 2.283 2.460 0.591
ENSG00000100075 E009 1044.8427516 0.0003502329 7.642021e-24 7.462670e-22 22 19175610 19175685 76 - 2.739 2.926 0.620
ENSG00000100075 E010 5713.4090886 0.0018687459 2.089206e-08 2.426843e-07 22 19175686 19176244 559 - 3.542 3.654 0.371
ENSG00000100075 E011 2448.4682818 0.0010472656 7.982973e-02 1.593021e-01 22 19176421 19176494 74 - 3.236 3.275 0.130
ENSG00000100075 E012 2596.8960938 0.0004308494 1.738488e-01 2.931945e-01 22 19176578 19176666 89 - 3.301 3.292 -0.027
ENSG00000100075 E013 1832.4867210 0.0001177999 7.333931e-04 3.019431e-03 22 19176667 19176693 27 - 3.166 3.136 -0.100
ENSG00000100075 E014 2664.6513165 0.0002217129 6.479279e-02 1.347030e-01 22 19176846 19176942 97 - 3.313 3.302 -0.038
ENSG00000100075 E015 1262.5557669 0.0016456183 1.253663e-02 3.481933e-02 22 19176943 19176950 8 - 3.019 2.971 -0.159
ENSG00000100075 E016 1961.1588353 0.0004703909 1.293594e-02 3.576217e-02 22 19177120 19177204 85 - 3.193 3.166 -0.088
ENSG00000100075 E017 1584.4350400 0.0032621758 2.453808e-01 3.804793e-01 22 19177727 19177865 139 - 3.099 3.075 -0.079
ENSG00000100075 E018 48.0482763 0.0028477828 4.434845e-07 3.963992e-06 22 19177866 19177941 76 - 1.799 1.496 -1.029
ENSG00000100075 E019 659.2115571 0.0017608088 1.312607e-01 2.359004e-01 22 19177942 19177946 5 - 2.723 2.692 -0.103
ENSG00000100075 E020 975.6403289 0.0016946190 3.756550e-01 5.200648e-01 22 19177947 19177989 43 - 2.878 2.866 -0.039
ENSG00000100075 E021 920.7396952 0.0020838060 3.289545e-01 4.724308e-01 22 19177990 19178041 52 - 2.856 2.840 -0.053
ENSG00000100075 E022 21.0251592 0.0045944470 3.962943e-04 1.760134e-03 22 19178042 19178132 91 - 1.458 1.156 -1.057
ENSG00000100075 E023 1115.3722553 0.0033753835 5.993784e-05 3.311474e-04 22 19178133 19178240 108 - 3.016 2.905 -0.369
ENSG00000100075 E024 96.0688204 0.0186643939 7.843127e-01 8.616610e-01 22 19178241 19178386 146 - 1.875 1.863 -0.041
ENSG00000100075 E025 153.6896766 0.0018206664 7.161489e-02 1.460270e-01 22 19178387 19178579 193 - 2.118 2.053 -0.220
ENSG00000100075 E026 456.8311850 0.0063808268 2.517931e-21 1.874320e-19 22 19178580 19178892 313 - 2.834 2.440 -1.311