ENSG00000099991

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263119 ENSG00000099991 HEK293_OSMI2_2hA HEK293_TMG_2hB CABIN1 protein_coding protein_coding 43.23058 62.12656 26.63303 3.285421 0.7450625 -1.221684 14.206348 15.761063 10.5405628 1.9819014 1.9284491 -0.5799599 0.35518750 0.25300000 0.39236667 0.139366667 2.320425e-01 4.335914e-42 FALSE TRUE
ENST00000337989 ENSG00000099991 HEK293_OSMI2_2hA HEK293_TMG_2hB CABIN1 protein_coding protein_coding 43.23058 62.12656 26.63303 3.285421 0.7450625 -1.221684 4.376579 12.470882 0.2798956 3.0472984 0.1122315 -5.4280425 0.07541250 0.20040000 0.01036667 -0.190033333 4.098524e-07 4.335914e-42 FALSE TRUE
ENST00000398319 ENSG00000099991 HEK293_OSMI2_2hA HEK293_TMG_2hB CABIN1 protein_coding protein_coding 43.23058 62.12656 26.63303 3.285421 0.7450625 -1.221684 8.052500 13.052205 4.8396414 2.3879947 1.8458560 -1.4294485 0.18010833 0.20933333 0.18593333 -0.023400000 8.541467e-01 4.335914e-42 FALSE TRUE
ENST00000445422 ENSG00000099991 HEK293_OSMI2_2hA HEK293_TMG_2hB CABIN1 protein_coding protein_coding 43.23058 62.12656 26.63303 3.285421 0.7450625 -1.221684 2.417216 0.000000 4.3645429 0.0000000 0.5563178 8.7729885 0.08293333 0.00000000 0.16300000 0.163000000 4.335914e-42 4.335914e-42 FALSE TRUE
ENST00000459824 ENSG00000099991 HEK293_OSMI2_2hA HEK293_TMG_2hB CABIN1 protein_coding retained_intron 43.23058 62.12656 26.63303 3.285421 0.7450625 -1.221684 4.403566 6.012618 2.0740849 0.5950684 0.1508364 -1.5309767 0.09512500 0.09636667 0.07830000 -0.018066667 4.771771e-01 4.335914e-42   FALSE
ENST00000485008 ENSG00000099991 HEK293_OSMI2_2hA HEK293_TMG_2hB CABIN1 protein_coding processed_transcript 43.23058 62.12656 26.63303 3.285421 0.7450625 -1.221684 2.733378 3.599997 1.3115968 0.2022558 0.1785366 -1.4497156 0.06075000 0.05830000 0.04923333 -0.009066667 6.970129e-01 4.335914e-42 FALSE TRUE
MSTRG.21812.11 ENSG00000099991 HEK293_OSMI2_2hA HEK293_TMG_2hB CABIN1 protein_coding   43.23058 62.12656 26.63303 3.285421 0.7450625 -1.221684 2.780018 5.816931 0.8987224 0.4140748 0.3817190 -2.6808248 0.05728333 0.09456667 0.03310000 -0.061466667 1.764758e-01 4.335914e-42 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000099991 E001 0.3268771 0.0295390632 5.167626e-01   22 24011192 24011303 112 + 0.176 0.083 -1.240
ENSG00000099991 E002 0.3268771 0.0295390632 5.167626e-01   22 24011304 24011314 11 + 0.176 0.083 -1.240
ENSG00000099991 E003 5.2284581 0.0119487315 2.771520e-01 4.166650e-01 22 24011315 24011340 26 + 0.845 0.701 -0.576
ENSG00000099991 E004 7.5815695 0.0023968996 6.648793e-02 1.375358e-01 22 24011341 24011347 7 + 1.021 0.813 -0.788
ENSG00000099991 E005 27.8710456 0.0152037881 4.221308e-03 1.376136e-02 22 24011348 24011367 20 + 1.563 1.325 -0.821
ENSG00000099991 E006 5.7667419 0.0030528052 2.279938e-03 8.089653e-03 22 24011368 24011415 48 + 1.021 0.642 -1.488
ENSG00000099991 E007 6.0257656 0.0045142519 6.598063e-04 2.751570e-03 22 24011416 24011417 2 + 1.061 0.642 -1.633
ENSG00000099991 E008 15.8884166 0.0011029765 7.473870e-07 6.379375e-06 22 24011418 24011439 22 + 1.432 1.022 -1.449
ENSG00000099991 E009 119.0079898 0.0096258182 2.583846e-04 1.210051e-03 22 24011440 24011728 289 + 2.154 1.960 -0.651
ENSG00000099991 E010 140.3143825 0.0095375914 5.198804e-05 2.916660e-04 22 24035444 24035520 77 + 2.235 2.026 -0.697
ENSG00000099991 E011 165.2809559 0.0098844947 2.600531e-07 2.436512e-06 22 24036089 24036181 93 + 2.342 2.076 -0.888
ENSG00000099991 E012 164.1124677 0.0119495729 1.973011e-07 1.892179e-06 22 24038348 24038461 114 + 2.354 2.064 -0.972
ENSG00000099991 E013 142.9539294 0.0190088212 7.978609e-05 4.268273e-04 22 24041139 24041273 135 + 2.278 2.015 -0.878
ENSG00000099991 E014 201.5872744 0.0126514568 5.702001e-05 3.166614e-04 22 24042904 24043084 181 + 2.397 2.180 -0.723
ENSG00000099991 E015 182.8104873 0.0057746429 7.150213e-09 9.051092e-08 22 24049091 24049220 130 + 2.371 2.127 -0.818
ENSG00000099991 E016 222.0618185 0.0012662024 2.275253e-19 1.357178e-17 22 24050825 24050974 150 + 2.460 2.208 -0.843
ENSG00000099991 E017 277.1034703 0.0002227839 7.535757e-34 1.697535e-31 22 24054873 24055067 195 + 2.561 2.298 -0.877
ENSG00000099991 E018 190.2989532 0.0010764916 5.635162e-21 4.053016e-19 22 24055068 24055159 92 + 2.403 2.130 -0.912
ENSG00000099991 E019 254.7264013 0.0024250081 3.433451e-15 1.210603e-13 22 24056192 24056360 169 + 2.512 2.270 -0.808
ENSG00000099991 E020 0.4772466 0.0207488148 8.701546e-01 9.204815e-01 22 24056361 24056525 165 + 0.176 0.153 -0.242
ENSG00000099991 E021 198.9281763 0.0061744697 1.969390e-04 9.506573e-04 22 24059227 24059363 137 + 2.348 2.196 -0.509
ENSG00000099991 E022 274.9136160 0.0044333204 4.355022e-08 4.755033e-07 22 24059924 24060141 218 + 2.517 2.322 -0.649
ENSG00000099991 E023 152.2307522 0.0030396829 1.253045e-06 1.019347e-05 22 24061947 24062025 79 + 2.249 2.071 -0.596
ENSG00000099991 E024 216.4937708 0.0067416966 7.591966e-04 3.112072e-03 22 24062959 24063146 188 + 2.376 2.238 -0.461
ENSG00000099991 E025 221.4968624 0.0094989109 1.636251e-02 4.352531e-02 22 24064035 24064187 153 + 2.363 2.258 -0.350
ENSG00000099991 E026 106.3237986 0.0070843242 1.315273e-02 3.626151e-02 22 24066987 24067004 18 + 2.055 1.936 -0.398
ENSG00000099991 E027 215.7633100 0.0043691296 3.123006e-05 1.850623e-04 22 24067005 24067181 177 + 2.384 2.231 -0.509
ENSG00000099991 E028 159.5976054 0.0002429237 1.168281e-04 5.993272e-04 22 24070800 24070890 91 + 2.220 2.115 -0.353
ENSG00000099991 E029 213.4118866 0.0014614530 1.329085e-03 5.072549e-03 22 24070891 24071042 152 + 2.333 2.245 -0.292
ENSG00000099991 E030 0.2214452 0.0382712101 1.000000e+00   22 24071043 24071183 141 + 0.000 0.084 8.166
ENSG00000099991 E031 235.1791331 0.0087121063 1.521267e-01 2.645737e-01 22 24072354 24072510 157 + 2.358 2.298 -0.199
ENSG00000099991 E032 202.7836310 0.0094797538 1.527198e-01 2.653659e-01 22 24076169 24076284 116 + 2.296 2.233 -0.213
ENSG00000099991 E033 250.5024577 0.0001835200 1.864578e-04 9.055777e-04 22 24083228 24083389 162 + 2.396 2.315 -0.267
ENSG00000099991 E034 342.7373283 0.0002784695 2.803619e-03 9.686099e-03 22 24084579 24084785 207 + 2.512 2.459 -0.177
ENSG00000099991 E035 261.7769633 0.0001785812 6.641619e-01 7.720227e-01 22 24085006 24085151 146 + 2.355 2.357 0.006
ENSG00000099991 E036 251.8570043 0.0002712530 3.107014e-01 4.531290e-01 22 24087452 24087587 136 + 2.351 2.337 -0.044
ENSG00000099991 E037 230.3015223 0.0004341899 9.148357e-01 9.500656e-01 22 24087588 24087713 126 + 2.290 2.306 0.054
ENSG00000099991 E038 345.6407438 0.0002371504 9.280403e-02 1.795051e-01 22 24091583 24091843 261 + 2.439 2.490 0.170
ENSG00000099991 E039 6.6884719 0.1276464298 4.863870e-01 6.241419e-01 22 24091844 24092013 170 + 0.700 0.887 0.742
ENSG00000099991 E040 269.7515789 0.0003831787 1.212432e-01 2.216993e-01 22 24095931 24096082 152 + 2.332 2.385 0.177
ENSG00000099991 E041 236.5616605 0.0003253418 9.194715e-01 9.531348e-01 22 24098014 24098105 92 + 2.308 2.318 0.033
ENSG00000099991 E042 126.9776733 0.0011916290 7.203275e-01 8.149579e-01 22 24098106 24098112 7 + 2.048 2.047 -0.003
ENSG00000099991 E043 218.6705092 0.0015000461 3.345221e-01 4.782706e-01 22 24098113 24098192 80 + 2.294 2.276 -0.059
ENSG00000099991 E044 1.3244194 0.4036552292 9.919319e-01 9.990617e-01 22 24098193 24098282 90 + 0.300 0.327 0.171
ENSG00000099991 E045 348.4567819 0.0001823941 8.661330e-01 9.177959e-01 22 24113566 24113748 183 + 2.469 2.486 0.055
ENSG00000099991 E046 455.5294087 0.0001303878 4.302486e-04 1.890904e-03 22 24119367 24119698 332 + 2.537 2.618 0.271
ENSG00000099991 E047 274.3031984 0.0001641116 4.660971e-01 6.056594e-01 22 24134302 24134415 114 + 2.354 2.385 0.102
ENSG00000099991 E048 2.2466458 0.0554411684 7.632840e-01 8.466423e-01 22 24155838 24156076 239 + 0.398 0.468 0.367
ENSG00000099991 E049 0.3332198 0.0295014676 5.166077e-01   22 24156533 24156576 44 + 0.176 0.083 -1.241
ENSG00000099991 E050 0.2944980 0.3303557040 9.348773e-02   22 24160330 24160406 77 + 0.301 0.000 -11.917
ENSG00000099991 E051 1.5456768 0.0091430472 6.418031e-01 7.547576e-01 22 24162066 24162215 150 + 0.301 0.395 0.566
ENSG00000099991 E052 312.9172917 0.0016356301 6.025305e-03 1.867843e-02 22 24164400 24164563 164 + 2.364 2.461 0.324
ENSG00000099991 E053 224.4145606 0.0002212480 8.892781e-07 7.466035e-06 22 24165530 24165626 97 + 2.172 2.325 0.512
ENSG00000099991 E054 609.4233752 0.0005682568 3.943469e-11 7.445469e-10 22 24166639 24167222 584 + 2.610 2.758 0.492
ENSG00000099991 E055 242.4258075 0.0002115595 1.159581e-14 3.777152e-13 22 24167223 24167313 91 + 2.142 2.374 0.776
ENSG00000099991 E056 262.1540259 0.0001885420 8.486043e-16 3.236673e-14 22 24168447 24168521 75 + 2.173 2.406 0.778
ENSG00000099991 E057 621.8139794 0.0015952633 9.376857e-15 3.096422e-13 22 24171713 24171995 283 + 2.566 2.782 0.717
ENSG00000099991 E058 27.6046867 0.0216222370 5.249965e-01 6.584158e-01 22 24173077 24173398 322 + 1.343 1.419 0.262
ENSG00000099991 E059 49.1948049 0.0004907369 1.605892e-01 2.759093e-01 22 24175779 24176110 332 + 1.568 1.662 0.318
ENSG00000099991 E060 472.0656057 0.0040916641 5.672484e-14 1.669725e-12 22 24176111 24176275 165 + 2.377 2.677 0.999
ENSG00000099991 E061 323.9510393 0.0059238951 1.846106e-12 4.331674e-11 22 24177504 24177590 87 + 2.178 2.520 1.140
ENSG00000099991 E062 624.9851746 0.0067228453 2.291363e-11 4.501160e-10 22 24177591 24177817 227 + 2.490 2.800 1.032
ENSG00000099991 E063 243.8661529 0.0061842639 8.582993e-08 8.823650e-07 22 24178053 24178056 4 + 2.113 2.387 0.918
ENSG00000099991 E064 980.5438204 0.0097708026 1.570194e-09 2.245724e-08 22 24178057 24178628 572 + 2.683 2.997 1.043