ENSG00000099958

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290730 ENSG00000099958 HEK293_OSMI2_2hA HEK293_TMG_2hB DERL3 protein_coding retained_intron 21.23636 27.70688 30.82644 1.697711 0.3456062 0.1538715 1.972338 2.830074 2.056614 0.1734905 0.19131886 -0.4586592 0.10464167 0.10243333 0.06660000 -0.03583333 0.04105951 0.0098232 FALSE  
ENST00000318109 ENSG00000099958 HEK293_OSMI2_2hA HEK293_TMG_2hB DERL3 protein_coding protein_coding 21.23636 27.70688 30.82644 1.697711 0.3456062 0.1538715 2.921925 4.395632 3.001061 0.5262221 0.08974672 -0.5490770 0.15613333 0.15830000 0.09746667 -0.06083333 0.00982320 0.0098232 FALSE  
ENST00000406855 ENSG00000099958 HEK293_OSMI2_2hA HEK293_TMG_2hB DERL3 protein_coding protein_coding 21.23636 27.70688 30.82644 1.697711 0.3456062 0.1538715 11.084245 13.631183 17.609841 1.0833262 0.77375172 0.3692322 0.48937083 0.49136667 0.57086667 0.07950000 0.15820215 0.0098232 FALSE  
ENST00000464110 ENSG00000099958 HEK293_OSMI2_2hA HEK293_TMG_2hB DERL3 protein_coding retained_intron 21.23636 27.70688 30.82644 1.697711 0.3456062 0.1538715 1.691134 2.651379 1.685048 0.2882145 0.47741585 -0.6508477 0.07755833 0.09506667 0.05473333 -0.04033333 0.21111125 0.0098232    
ENST00000476077 ENSG00000099958 HEK293_OSMI2_2hA HEK293_TMG_2hB DERL3 protein_coding protein_coding 21.23636 27.70688 30.82644 1.697711 0.3456062 0.1538715 2.432105 3.079607 4.143094 0.3677714 0.99212528 0.4267635 0.11532917 0.11216667 0.13430000 0.02213333 0.88453930 0.0098232 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000099958 E001 248.409055 0.0049933323 3.762238e-01 5.205746e-01 22 23834503 23834932 430 - 2.370 2.407 0.125
ENSG00000099958 E002 295.166954 0.0001871392 1.274893e-12 3.073614e-11 22 23834933 23836299 1367 - 2.372 2.521 0.496
ENSG00000099958 E003 65.084227 0.0004137935 1.253061e-01 2.275713e-01 22 23836300 23836464 165 - 1.770 1.839 0.233
ENSG00000099958 E004 32.071074 0.0008617667 1.022374e-02 2.931701e-02 22 23836465 23836519 55 - 1.412 1.575 0.562
ENSG00000099958 E005 53.902608 0.0046307302 8.685731e-04 3.504090e-03 22 23836520 23836733 214 - 1.605 1.804 0.675
ENSG00000099958 E006 31.372265 0.0033068775 3.579419e-02 8.318363e-02 22 23836734 23836766 33 - 1.406 1.551 0.501
ENSG00000099958 E007 113.547237 0.0003173970 2.658895e-03 9.249350e-03 22 23836767 23836962 196 - 1.989 2.091 0.344
ENSG00000099958 E008 47.553374 0.0020528487 8.544531e-04 3.453598e-03 22 23836963 23837063 101 - 1.566 1.753 0.634
ENSG00000099958 E009 228.111312 0.0005196613 2.625399e-01 4.003299e-01 22 23837064 23837154 91 - 2.334 2.363 0.098
ENSG00000099958 E010 6.884925 0.0025282689 1.263571e-01 2.290759e-01 22 23837155 23837217 63 - 0.765 0.954 0.730
ENSG00000099958 E011 6.508497 0.0125860918 4.332771e-01 5.756861e-01 22 23837647 23837658 12 - 0.916 0.816 -0.382
ENSG00000099958 E012 229.972080 0.0006649175 7.814499e-01 8.595834e-01 22 23837659 23837731 73 - 2.356 2.351 -0.016
ENSG00000099958 E013 204.831264 0.0004026320 2.991501e-01 4.406480e-01 22 23837732 23837815 84 - 2.319 2.294 -0.083
ENSG00000099958 E014 170.115165 0.0004049914 1.149328e-01 2.127441e-01 22 23837816 23837854 39 - 2.251 2.209 -0.141
ENSG00000099958 E015 14.835301 0.0042476271 7.673807e-02 1.542685e-01 22 23838138 23838351 214 - 1.080 1.247 0.596
ENSG00000099958 E016 242.538421 0.0004950506 3.620243e-06 2.661406e-05 22 23838352 23838445 94 - 2.437 2.328 -0.362
ENSG00000099958 E017 215.427183 0.0004720722 1.607186e-05 1.018759e-04 22 23838564 23838637 74 - 2.385 2.278 -0.355
ENSG00000099958 E018 8.808992 0.0019114899 7.924057e-01 8.672773e-01 22 23838638 23838710 73 - 0.967 0.996 0.110
ENSG00000099958 E019 134.662306 0.0002417704 5.046163e-02 1.099865e-01 22 23838711 23838716 6 - 2.157 2.099 -0.195
ENSG00000099958 E020 190.377859 0.0002972659 1.091815e-04 5.642763e-04 22 23838717 23838776 60 - 2.327 2.228 -0.329
ENSG00000099958 E021 76.925516 0.0003339624 7.525502e-02 1.519417e-01 22 23838777 23838894 118 - 1.840 1.913 0.247
ENSG00000099958 E022 154.610340 0.0003172546 6.932044e-05 3.767571e-04 22 23838895 23839128 234 - 2.245 2.132 -0.377