ENSG00000099917

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263205 ENSG00000099917 HEK293_OSMI2_2hA HEK293_TMG_2hB MED15 protein_coding protein_coding 44.8678 60.68855 30.22915 2.681175 0.6696789 -1.005244 7.728045 10.1020253 4.960300 1.0202558 0.4814106 -1.0246672 0.17072917 0.16583333 0.1646000 -0.001233333 1.0000000000 3.643104e-12 FALSE TRUE
ENST00000292733 ENSG00000099917 HEK293_OSMI2_2hA HEK293_TMG_2hB MED15 protein_coding protein_coding 44.8678 60.68855 30.22915 2.681175 0.6696789 -1.005244 16.783505 21.1809837 11.556577 1.6508697 1.3647775 -0.8734886 0.37822917 0.34863333 0.3840667 0.035433333 0.8390168219 3.643104e-12 FALSE TRUE
ENST00000414658 ENSG00000099917 HEK293_OSMI2_2hA HEK293_TMG_2hB MED15 protein_coding protein_coding 44.8678 60.68855 30.22915 2.681175 0.6696789 -1.005244 1.416085 0.6826363 2.097416 0.6826363 0.4430619 1.6053050 0.03852917 0.01106667 0.0700000 0.058933333 0.0870475550 3.643104e-12 FALSE FALSE
ENST00000473244 ENSG00000099917 HEK293_OSMI2_2hA HEK293_TMG_2hB MED15 protein_coding retained_intron 44.8678 60.68855 30.22915 2.681175 0.6696789 -1.005244 5.405974 9.3522129 1.155387 0.7600569 0.3060035 -3.0060408 0.10631250 0.15500000 0.0380000 -0.117000000 0.0002340643 3.643104e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000099917 E001 0.0000000       22 20495913 20495923 11 +      
ENSG00000099917 E002 0.8835181 0.7334864867 7.654699e-01 8.482342e-01 22 20495924 20495989 66 + 0.299 0.251 -0.342
ENSG00000099917 E003 7.1794378 0.0023767684 9.365063e-02 1.808285e-01 22 20495990 20496036 47 + 0.998 0.801 -0.752
ENSG00000099917 E004 13.0972156 0.0196914615 1.002957e-01 1.909293e-01 22 20498667 20498791 125 + 1.229 1.053 -0.628
ENSG00000099917 E005 7.3933294 0.0027675582 5.607373e-01 6.886996e-01 22 20499241 20499366 126 + 0.811 0.893 0.315
ENSG00000099917 E006 9.8157091 0.0127485414 1.038181e-01 1.963269e-01 22 20500741 20500836 96 + 1.112 0.927 -0.683
ENSG00000099917 E007 5.9376166 0.0150280289 6.967265e-01 7.970006e-01 22 20500837 20500929 93 + 0.739 0.802 0.252
ENSG00000099917 E008 1.9498600 0.0163513493 3.880465e-01 5.321605e-01 22 20507291 20507394 104 + 0.543 0.396 -0.742
ENSG00000099917 E009 2.7550278 0.0136741481 6.226997e-01 7.394435e-01 22 20507541 20507581 41 + 0.600 0.523 -0.354
ENSG00000099917 E010 2.3550979 0.0081895508 4.961139e-01 6.328475e-01 22 20507582 20507582 1 + 0.397 0.524 0.647
ENSG00000099917 E011 2.9034202 0.0059552382 5.787846e-01 7.037910e-01 22 20507583 20507584 2 + 0.476 0.576 0.474
ENSG00000099917 E012 4.3761484 0.0037945625 3.429700e-01 4.870049e-01 22 20507585 20507593 9 + 0.776 0.644 -0.547
ENSG00000099917 E013 4.6716906 0.0035662388 2.826071e-01 4.226269e-01 22 20507594 20507594 1 + 0.811 0.664 -0.598
ENSG00000099917 E014 10.6354296 0.0024213075 7.647729e-01 8.477553e-01 22 20507595 20507601 7 + 0.976 1.016 0.148
ENSG00000099917 E015 20.9911833 0.0008763570 1.667011e-01 2.839025e-01 22 20507602 20507609 8 + 1.360 1.256 -0.363
ENSG00000099917 E016 21.1353118 0.0008763360 9.019615e-02 1.754226e-01 22 20507610 20507611 2 + 1.378 1.251 -0.445
ENSG00000099917 E017 25.8583236 0.0007544351 3.554821e-02 8.270601e-02 22 20507612 20507617 6 + 1.475 1.331 -0.499
ENSG00000099917 E018 69.9177486 0.0083657451 8.471490e-04 3.427659e-03 22 20507618 20507640 23 + 1.927 1.730 -0.665
ENSG00000099917 E019 172.4046966 0.0090788970 4.449390e-04 1.947155e-03 22 20507641 20507735 95 + 2.304 2.127 -0.591
ENSG00000099917 E020 131.7005018 0.0148392240 1.714519e-02 4.526281e-02 22 20507736 20507746 11 + 2.167 2.022 -0.484
ENSG00000099917 E021 0.0000000       22 20508048 20508056 9 +      
ENSG00000099917 E022 1.5875085 0.0099001681 4.890915e-01 6.265937e-01 22 20508057 20508444 388 + 0.476 0.357 -0.643
ENSG00000099917 E023 24.7199850 0.0164452513 5.405919e-05 3.020424e-04 22 20518878 20518995 118 + 1.589 1.227 -1.254
ENSG00000099917 E024 0.1451727 0.0425716808 2.042497e-01   22 20523643 20523855 213 + 0.175 0.000 -12.038
ENSG00000099917 E025 0.0000000       22 20524275 20524286 12 +      
ENSG00000099917 E026 0.0000000       22 20524287 20524366 80 +      
ENSG00000099917 E027 239.2157227 0.0077729010 2.634085e-04 1.230567e-03 22 20537117 20537204 88 + 2.439 2.273 -0.553
ENSG00000099917 E028 2.1455120 0.0238365068 2.179478e-03 7.778447e-03 22 20537205 20537215 11 + 0.777 0.267 -2.551
ENSG00000099917 E029 0.1482932 0.0414692439 1.000000e+00   22 20550987 20551006 20 + 0.000 0.084 9.912
ENSG00000099917 E030 0.3697384 0.0274424043 5.550277e-01 6.839272e-01 22 20551007 20551166 160 + 0.000 0.154 11.076
ENSG00000099917 E031 0.2214452 0.0376528805 1.000000e+00   22 20551167 20551240 74 + 0.000 0.084 9.959
ENSG00000099917 E032 0.2214452 0.0376528805 1.000000e+00   22 20551241 20551289 49 + 0.000 0.084 9.959
ENSG00000099917 E033 0.0000000       22 20551290 20551312 23 +      
ENSG00000099917 E034 0.0000000       22 20551313 20551347 35 +      
ENSG00000099917 E035 0.1451727 0.0425716808 2.042497e-01   22 20551407 20551435 29 + 0.175 0.000 -12.038
ENSG00000099917 E036 190.9742007 0.0058174450 2.381812e-04 1.125732e-03 22 20551436 20551487 52 + 2.337 2.178 -0.533
ENSG00000099917 E037 2.6916297 0.0059321150 2.955444e-02 7.108346e-02 22 20551488 20551748 261 + 0.739 0.396 -1.587
ENSG00000099917 E038 2.1411293 0.0069956822 2.160593e-01 3.456609e-01 22 20552539 20552709 171 + 0.601 0.396 -1.004
ENSG00000099917 E039 0.1515154 0.0425307145 2.041673e-01   22 20553097 20553144 48 + 0.175 0.000 -12.040
ENSG00000099917 E040 151.7693580 0.0029431308 1.510056e-05 9.633147e-05 22 20553145 20553174 30 + 2.240 2.076 -0.547
ENSG00000099917 E041 2.5422741 0.1101600781 3.406386e-01 4.845877e-01 22 20554239 20554935 697 + 0.300 0.536 1.290
ENSG00000099917 E042 166.6270914 0.0002787288 3.804042e-07 3.444858e-06 22 20554936 20554995 60 + 2.266 2.123 -0.481
ENSG00000099917 E043 166.5723008 0.0018507134 3.319607e-04 1.508418e-03 22 20554996 20555076 81 + 2.250 2.130 -0.400
ENSG00000099917 E044 159.8607593 0.0032169838 1.607340e-03 5.984898e-03 22 20555077 20555148 72 + 2.230 2.112 -0.395
ENSG00000099917 E045 201.5290736 0.0022800213 6.287082e-04 2.638352e-03 22 20564450 20564688 239 + 2.325 2.215 -0.369
ENSG00000099917 E046 1.1081987 0.0155232661 4.649504e-01 6.046449e-01 22 20566465 20566466 2 + 0.397 0.267 -0.813
ENSG00000099917 E047 265.2677381 0.0002190532 5.771121e-03 1.801159e-02 22 20566467 20566817 351 + 2.410 2.350 -0.200
ENSG00000099917 E048 172.8429096 0.0028600020 2.423751e-01 3.769783e-01 22 20568521 20568631 111 + 2.207 2.171 -0.123
ENSG00000099917 E049 28.7774507 0.0028938754 4.624115e-03 1.488598e-02 22 20573678 20575112 1435 + 1.548 1.353 -0.672
ENSG00000099917 E050 59.9531721 0.0053886874 5.128833e-01 6.477678e-01 22 20575113 20575232 120 + 1.746 1.715 -0.106
ENSG00000099917 E051 23.6415206 0.0008140380 6.572090e-03 2.011410e-02 22 20581901 20582093 193 + 1.144 1.384 0.842
ENSG00000099917 E052 41.9807471 0.0011638748 4.409792e-03 1.429146e-02 22 20582094 20582610 517 + 1.421 1.616 0.665
ENSG00000099917 E053 102.6214442 0.0015418761 7.702194e-03 2.303109e-02 22 20582611 20582658 48 + 1.855 1.982 0.426
ENSG00000099917 E054 90.2775129 0.0012483146 6.467571e-05 3.542755e-04 22 20582659 20582697 39 + 1.742 1.940 0.666
ENSG00000099917 E055 104.3351561 0.0003112406 3.373404e-02 7.922266e-02 22 20582698 20582747 50 + 1.890 1.982 0.309
ENSG00000099917 E056 4.6518927 0.0158159569 4.149294e-01 5.583408e-01 22 20582748 20582839 92 + 0.601 0.738 0.580
ENSG00000099917 E057 200.7776222 0.0001899592 1.300745e-01 2.342683e-01 22 20582840 20582929 90 + 2.208 2.257 0.167
ENSG00000099917 E058 188.9882904 0.0002192380 8.248842e-01 8.896640e-01 22 20582930 20582967 38 + 2.210 2.223 0.044
ENSG00000099917 E059 2.7886254 0.0987209138 8.313909e-01 8.943175e-01 22 20582968 20583112 145 + 0.475 0.533 0.281
ENSG00000099917 E060 355.3451063 0.0004001279 4.849707e-01 6.229049e-01 22 20583113 20583247 135 + 2.477 2.500 0.077
ENSG00000099917 E061 181.9123743 0.0003236496 8.264231e-01 8.907641e-01 22 20583330 20583333 4 + 2.205 2.205 0.001
ENSG00000099917 E062 195.6198975 0.0015861388 3.192725e-01 4.623368e-01 22 20583334 20583337 4 + 2.206 2.248 0.141
ENSG00000099917 E063 304.3662136 0.0002459768 2.121981e-01 3.411189e-01 22 20583338 20583393 56 + 2.400 2.437 0.121
ENSG00000099917 E064 23.1864093 0.0167135438 2.975743e-01 4.389413e-01 22 20583394 20584358 965 + 1.388 1.295 -0.322
ENSG00000099917 E065 307.7674932 0.0001985620 5.152553e-03 1.634493e-02 22 20584359 20584425 67 + 2.376 2.449 0.242
ENSG00000099917 E066 26.3985255 0.0009029413 6.875274e-02 1.413027e-01 22 20584426 20584854 429 + 1.468 1.344 -0.429
ENSG00000099917 E067 353.0198457 0.0002132888 8.285348e-02 1.640144e-01 22 20584855 20584945 91 + 2.456 2.501 0.150
ENSG00000099917 E068 348.0263724 0.0001939339 1.741983e-01 2.936376e-01 22 20584946 20585015 70 + 2.456 2.493 0.122
ENSG00000099917 E069 30.4490048 0.0122097413 7.608500e-01 8.448310e-01 22 20585016 20585100 85 + 1.405 1.443 0.133
ENSG00000099917 E070 511.6008632 0.0022834302 1.682392e-01 2.859130e-01 22 20585101 20585267 167 + 2.615 2.664 0.162
ENSG00000099917 E071 23.7996639 0.0179311207 5.280224e-02 1.141400e-01 22 20585268 20585727 460 + 1.468 1.294 -0.602
ENSG00000099917 E072 409.3653315 0.0036698234 3.373290e-01 4.811979e-01 22 20585728 20585826 99 + 2.523 2.567 0.145
ENSG00000099917 E073 1639.3656279 0.0018224997 3.290160e-12 7.418603e-11 22 20586568 20587632 1065 + 3.044 3.192 0.491