ENSG00000099901

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331821 ENSG00000099901 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP1 protein_coding protein_coding 755.4601 919.1281 711.2218 62.29767 4.338647 -0.3699619 389.0689 562.17879 328.6091 51.70212 13.089108 -0.7746384 0.5092042 0.6100000 0.4619000 -0.148100000 0.0002274139 6.108274e-32 FALSE TRUE
ENST00000402752 ENSG00000099901 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP1 protein_coding protein_coding 755.4601 919.1281 711.2218 62.29767 4.338647 -0.3699619 182.8967 228.59349 172.7804 15.78598 3.552786 -0.4038241 0.2402375 0.2486667 0.2429000 -0.005766667 0.7834692905 6.108274e-32 FALSE TRUE
ENST00000411892 ENSG00000099901 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP1 protein_coding protein_coding 755.4601 919.1281 711.2218 62.29767 4.338647 -0.3699619 146.7905 90.95587 177.3248 14.00586 13.856529 0.9630785 0.2002500 0.1008667 0.2495333 0.148666667 0.0019471522 6.108274e-32 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000099901 E001 1.690864 0.0098041110 6.756468e-01 7.808594e-01 22 20115938 20116103 166 + 0.479 0.411 -0.351
ENSG00000099901 E002 14.190779 0.0464387206 2.006560e-04 9.666295e-04 22 20116104 20116395 292 + 1.420 0.939 -1.718
ENSG00000099901 E003 10.120512 0.0221917260 3.976763e-05 2.293202e-04 22 20116396 20116430 35 + 1.289 0.794 -1.822
ENSG00000099901 E004 76.115530 0.0367519460 4.459255e-07 3.983743e-06 22 20117424 20117523 100 + 2.132 1.601 -1.791
ENSG00000099901 E005 287.023563 0.0282273857 1.057273e-07 1.069335e-06 22 20117524 20117547 24 + 2.679 2.217 -1.543
ENSG00000099901 E006 480.309182 0.0182135405 2.852890e-05 1.705764e-04 22 20117548 20117556 9 + 2.828 2.536 -0.969
ENSG00000099901 E007 2958.455307 0.0047009167 2.971873e-05 1.770424e-04 22 20117557 20117652 96 + 3.537 3.396 -0.467
ENSG00000099901 E008 2157.721405 0.0037478019 3.429900e-03 1.152406e-02 22 20117653 20117664 12 + 3.372 3.279 -0.307
ENSG00000099901 E009 9.162303 0.0089765454 2.273653e-02 5.720656e-02 22 20117782 20117874 93 + 1.142 0.893 -0.916
ENSG00000099901 E010 15.646795 0.0012213372 5.445838e-01 6.750247e-01 22 20117875 20117912 38 + 1.243 1.197 -0.162
ENSG00000099901 E011 8.587823 0.0286074620 9.427175e-01 9.680346e-01 22 20117913 20117933 21 + 0.957 0.972 0.057
ENSG00000099901 E012 14.243155 0.0012751921 3.388848e-01 4.827955e-01 22 20117934 20117952 19 + 1.222 1.143 -0.282
ENSG00000099901 E013 26.589846 0.0007204184 6.095073e-02 1.282366e-01 22 20117953 20118016 64 + 1.499 1.378 -0.416
ENSG00000099901 E014 45.132627 0.0005062276 7.500174e-02 1.515336e-01 22 20118017 20118131 115 + 1.706 1.618 -0.299
ENSG00000099901 E015 75.871846 0.0045115299 4.809028e-02 1.057891e-01 22 20118132 20118313 182 + 1.932 1.834 -0.331
ENSG00000099901 E016 6170.785188 0.0001868767 1.141335e-03 4.441892e-03 22 20119013 20119149 137 + 3.787 3.764 -0.076
ENSG00000099901 E017 18.416045 0.0144174386 3.425243e-02 8.024112e-02 22 20119150 20119529 380 + 1.386 1.178 -0.729
ENSG00000099901 E018 7910.394101 0.0003629860 3.761285e-01 5.204997e-01 22 20122264 20122421 158 + 3.874 3.883 0.029
ENSG00000099901 E019 37.727501 0.0113538896 3.323435e-10 5.367560e-09 22 20122422 20122579 158 + 1.818 1.333 -1.658
ENSG00000099901 E020 25.890612 0.0012485644 1.345295e-07 1.333309e-06 22 20122580 20122606 27 + 1.606 1.252 -1.226
ENSG00000099901 E021 33.164931 0.0069063006 6.457109e-09 8.252023e-08 22 20122607 20122697 91 + 1.736 1.322 -1.419
ENSG00000099901 E022 147.825731 0.0092666264 4.772495e-11 8.894587e-10 22 20124139 20125307 1169 + 2.353 1.985 -1.230
ENSG00000099901 E023 7636.467165 0.0004651022 9.470901e-05 4.971554e-04 22 20125308 20125436 129 + 3.838 3.877 0.128
ENSG00000099901 E024 23.889143 0.0346446653 4.337347e-03 1.408946e-02 22 20125437 20125488 52 + 1.557 1.237 -1.109
ENSG00000099901 E025 5281.563902 0.0004996188 5.577715e-05 3.105420e-04 22 20126303 20126368 66 + 3.674 3.720 0.150
ENSG00000099901 E026 59.894494 0.0143373681 5.582045e-03 1.750599e-02 22 20126369 20126401 33 + 1.887 1.678 -0.705
ENSG00000099901 E027 252.598791 0.0022669880 7.077580e-01 8.055527e-01 22 20126402 20126951 550 + 2.376 2.389 0.042
ENSG00000099901 E028 1832.841355 0.0007268744 3.963692e-01 5.401410e-01 22 20126952 20126954 3 + 3.235 3.251 0.053
ENSG00000099901 E029 6308.310928 0.0010145765 7.798095e-14 2.253395e-12 22 20126955 20127355 401 + 3.708 3.815 0.356