ENSG00000099814

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000251181 ENSG00000099814 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP170B protein_coding retained_intron 20.49289 31.09983 14.51993 2.309752 0.2448263 -1.098342 4.775757 11.7181814 1.0393836 1.3605406 0.11801774 -3.48236524 0.19135833 0.38093333 0.07136667 -0.30956667 7.179693e-09 7.179693e-09 FALSE TRUE
ENST00000556508 ENSG00000099814 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP170B protein_coding protein_coding 20.49289 31.09983 14.51993 2.309752 0.2448263 -1.098342 3.209382 2.6009734 2.4813074 0.3902528 0.21729333 -0.06768474 0.16187083 0.08296667 0.17046667 0.08750000 1.572678e-04 7.179693e-09 FALSE TRUE
MSTRG.10268.3 ENSG00000099814 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP170B protein_coding   20.49289 31.09983 14.51993 2.309752 0.2448263 -1.098342 9.126534 13.5476225 8.5039760 2.0767188 0.52646206 -0.67119928 0.46660833 0.43150000 0.58663333 0.15513333 1.732997e-01 7.179693e-09 FALSE TRUE
MSTRG.10268.5 ENSG00000099814 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP170B protein_coding   20.49289 31.09983 14.51993 2.309752 0.2448263 -1.098342 1.842672 0.9749762 0.8704112 0.2619919 0.37067818 -0.16191137 0.09399583 0.03216667 0.05913333 0.02696667 6.638712e-01 7.179693e-09 FALSE TRUE
MSTRG.10268.6 ENSG00000099814 HEK293_OSMI2_2hA HEK293_TMG_2hB CEP170B protein_coding   20.49289 31.09983 14.51993 2.309752 0.2448263 -1.098342 0.987229 1.7950301 0.6116211 0.4129773 0.09466471 -1.53791546 0.05464167 0.05790000 0.04193333 -0.01596667 6.746786e-01 7.179693e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000099814 E001 0.0000000       14 104865268 104865279 12 +      
ENSG00000099814 E002 0.1472490 0.0427989837 2.772726e-01   14 104865280 104865291 12 + 0.149 0.000 -10.193
ENSG00000099814 E003 0.9307487 0.0571556826 2.320069e-02 5.816506e-02 14 104865292 104865367 76 + 0.485 0.100 -2.989
ENSG00000099814 E004 2.0692381 0.2418576309 6.914257e-02 1.419561e-01 14 104865368 104865415 48 + 0.672 0.310 -1.829
ENSG00000099814 E005 5.5683143 0.0179888167 4.992479e-03 1.590800e-02 14 104865416 104865425 10 + 0.983 0.641 -1.352
ENSG00000099814 E006 38.8333987 0.0180646008 3.830725e-02 8.792655e-02 14 104865426 104865513 88 + 1.644 1.530 -0.386
ENSG00000099814 E007 4.8168869 0.0033886625 4.222174e-01 5.653792e-01 14 104866856 104867007 152 + 0.631 0.790 0.656
ENSG00000099814 E008 71.7851634 0.0035302719 3.243884e-03 1.098400e-02 14 104868424 104868555 132 + 1.892 1.799 -0.315
ENSG00000099814 E009 101.8010526 0.0021908152 6.387546e-09 8.174152e-08 14 104876256 104876345 90 + 2.098 1.912 -0.623
ENSG00000099814 E010 104.3740709 0.0037417911 3.771514e-09 5.025335e-08 14 104877885 104877963 79 + 2.124 1.913 -0.710
ENSG00000099814 E011 99.4735286 0.0024834772 1.277348e-09 1.856318e-08 14 104878443 104878501 59 + 2.099 1.895 -0.686
ENSG00000099814 E012 143.4627280 0.0003221208 2.592918e-20 1.716954e-18 14 104880287 104880425 139 + 2.267 2.041 -0.758
ENSG00000099814 E013 95.9900965 0.0058677240 3.483906e-06 2.571283e-05 14 104882728 104882832 105 + 2.071 1.889 -0.611
ENSG00000099814 E014 189.0967664 0.0007406095 1.481680e-17 7.097339e-16 14 104883035 104883508 474 + 2.366 2.177 -0.631
ENSG00000099814 E015 294.4259385 0.0006312603 1.289291e-09 1.872527e-08 14 104883831 104884549 719 + 2.499 2.411 -0.296
ENSG00000099814 E016 2.0574699 0.0071509456 6.391328e-02 1.332111e-01 14 104884550 104884566 17 + 0.631 0.360 -1.344
ENSG00000099814 E017 150.4269709 0.0003512676 9.066933e-03 2.644655e-02 14 104885369 104885542 174 + 2.170 2.143 -0.090
ENSG00000099814 E018 98.7080047 0.0080699639 4.210820e-01 5.642194e-01 14 104886040 104886130 91 + 1.958 1.976 0.060
ENSG00000099814 E019 197.3490237 0.0042410158 6.395169e-02 1.332731e-01 14 104886275 104886583 309 + 2.281 2.266 -0.051
ENSG00000099814 E020 208.7390724 0.0021431090 2.622401e-01 4.000077e-01 14 104886584 104886918 335 + 2.283 2.301 0.061
ENSG00000099814 E021 636.1394676 0.0004136468 9.972366e-01 1.000000e+00 14 104886919 104887978 1060 + 2.737 2.793 0.186
ENSG00000099814 E022 191.0553156 0.0013198658 3.002669e-01 4.419291e-01 14 104889515 104889619 105 + 2.192 2.281 0.298
ENSG00000099814 E023 219.8733575 0.0007485731 2.151207e-01 3.445731e-01 14 104889620 104889758 139 + 2.252 2.342 0.300
ENSG00000099814 E024 258.1290611 0.0017840384 2.188452e-02 5.543545e-02 14 104892976 104893135 160 + 2.295 2.424 0.429
ENSG00000099814 E025 279.2804734 0.0001671577 4.050864e-01 5.487694e-01 14 104893523 104893666 144 + 2.370 2.442 0.240
ENSG00000099814 E026 231.4356408 0.0004839301 7.243801e-01 8.179117e-01 14 104893761 104893849 89 + 2.307 2.352 0.149
ENSG00000099814 E027 9.8646293 0.0199500214 4.097281e-03 1.341660e-02 14 104893934 104894284 351 + 1.186 0.888 -1.092
ENSG00000099814 E028 257.7249834 0.0001750276 3.822453e-01 5.264763e-01 14 104894285 104894378 94 + 2.363 2.395 0.108
ENSG00000099814 E029 192.0788737 0.0028256059 5.211400e-01 6.550321e-01 14 104894537 104894588 52 + 2.204 2.284 0.267
ENSG00000099814 E030 1519.4975383 0.0059040059 1.337308e-11 2.729171e-10 14 104894711 104896747 2037 + 2.967 3.233 0.883