ENSG00000099785

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000215555 ENSG00000099785 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF2 protein_coding protein_coding 12.31642 22.59402 4.803297 1.087453 0.1979136 -2.231482 3.0278314 4.799714 1.3712314 1.4368899 0.6051508 -1.7999962 0.22569167 0.20803333 0.28063333 0.072600000 0.86746737 0.002518886 FALSE  
ENST00000381035 ENSG00000099785 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF2 protein_coding protein_coding 12.31642 22.59402 4.803297 1.087453 0.1979136 -2.231482 1.6189532 2.776291 0.5436475 0.3282901 0.1947687 -2.3313062 0.13697083 0.12206667 0.11360000 -0.008466667 0.90795990 0.002518886 FALSE  
ENST00000602117 ENSG00000099785 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF2 protein_coding protein_coding 12.31642 22.59402 4.803297 1.087453 0.1979136 -2.231482 1.3047885 1.842369 0.3750113 0.1980690 0.1099827 -2.2663983 0.11615833 0.08103333 0.07713333 -0.003900000 0.95352569 0.002518886 FALSE  
MSTRG.16351.2 ENSG00000099785 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF2 protein_coding   12.31642 22.59402 4.803297 1.087453 0.1979136 -2.231482 3.1482617 6.397163 1.6092909 0.9269885 0.3366611 -1.9843234 0.24281250 0.28303333 0.34206667 0.059033333 0.83358917 0.002518886 FALSE  
MSTRG.16351.4 ENSG00000099785 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF2 protein_coding   12.31642 22.59402 4.803297 1.087453 0.1979136 -2.231482 0.9923867 3.069154 0.2356943 0.3984687 0.2356943 -3.6475980 0.06705833 0.13820000 0.04840000 -0.089800000 0.21513371 0.002518886 FALSE  
MSTRG.16351.9 ENSG00000099785 HEK293_OSMI2_2hA HEK293_TMG_2hB MARCHF2 protein_coding   12.31642 22.59402 4.803297 1.087453 0.1979136 -2.231482 0.9589201 1.069667 0.6049992 0.2531145 0.1321171 -0.8119297 0.09772917 0.04643333 0.12513333 0.078700000 0.03681788 0.002518886 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000099785 E001 0.4448795 0.5308019556 1.00000000 1.00000000 19 8413270 8413286 17 + 0.000 0.150 9.724
ENSG00000099785 E002 0.1515154 0.0442821763 0.08152195   19 8413287 8413288 2 + 0.237 0.000 -14.629
ENSG00000099785 E003 0.1515154 0.0442821763 0.08152195   19 8413289 8413289 1 + 0.237 0.000 -14.629
ENSG00000099785 E004 0.3030308 0.4528054176 0.04093348   19 8413290 8413294 5 + 0.390 0.000 -14.270
ENSG00000099785 E005 1.9897407 0.0476237353 0.05850965 0.12408044 19 8413295 8413304 10 + 0.665 0.306 -1.821
ENSG00000099785 E006 34.3940817 0.0087031771 0.30659731 0.44877068 19 8413305 8413420 116 + 1.466 1.377 -0.307
ENSG00000099785 E007 7.7184063 0.1149264193 0.08624230 0.16938451 19 8413422 8413719 298 + 1.047 0.736 -1.188
ENSG00000099785 E008 5.7338915 0.0253801890 0.01489065 0.04024005 19 8413720 8413742 23 + 0.986 0.613 -1.486
ENSG00000099785 E009 6.2519230 0.0042999917 0.01876184 0.04881109 19 8413743 8413794 52 + 0.986 0.655 -1.304
ENSG00000099785 E010 4.5223612 0.0037284125 0.89959760 0.93993410 19 8418405 8418536 132 + 0.590 0.610 0.088
ENSG00000099785 E011 10.9183758 0.0240984735 0.34460165 0.48869105 19 8418537 8418538 2 + 1.047 0.914 -0.494
ENSG00000099785 E012 66.5298010 0.0004748145 0.85301188 0.90895078 19 8418539 8418741 203 + 1.668 1.676 0.026
ENSG00000099785 E013 60.5786985 0.0007781938 0.75483558 0.84035386 19 8418742 8418807 66 + 1.626 1.642 0.055
ENSG00000099785 E014 116.7893675 0.0002806962 0.15235715 0.26489119 19 8421789 8421926 138 + 1.968 1.906 -0.209
ENSG00000099785 E015 78.6949623 0.0003482432 0.75004272 0.83681784 19 8421927 8421951 25 + 1.765 1.745 -0.066
ENSG00000099785 E016 103.3068797 0.0003991444 0.78421385 0.86156309 19 8421952 8422016 65 + 1.878 1.863 -0.052
ENSG00000099785 E017 145.4311929 0.0002604026 0.07484640 0.15128111 19 8426609 8426804 196 + 1.951 2.018 0.226
ENSG00000099785 E018 156.9455522 0.0015636676 0.12397058 0.22563027 19 8430658 8430867 210 + 1.988 2.049 0.207
ENSG00000099785 E019 1.5144556 0.0096826855 0.68370852 0.78684523 19 8430868 8430892 25 + 0.389 0.306 -0.500
ENSG00000099785 E020 175.0279162 0.0040484354 0.70318422 0.80189338 19 8438388 8438534 147 + 2.103 2.087 -0.054
ENSG00000099785 E021 201.1397703 0.0017996373 0.15479345 0.26813446 19 8438535 8439017 483 + 2.108 2.159 0.169