ENSG00000099783

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000325495 ENSG00000099783 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPM protein_coding protein_coding 356.9644 457.5611 288.1357 18.43351 3.973676 -0.6671976 247.92401 330.58731 202.052945 9.498415 4.0515003 -0.7102702 0.69299167 0.72350000 0.7011000 -0.02240000 7.041667e-01 5.985511e-53 FALSE TRUE
ENST00000348943 ENSG00000099783 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPM protein_coding protein_coding 356.9644 457.5611 288.1357 18.43351 3.973676 -0.6671976 21.63745 52.77446 0.000000 8.435526 0.0000000 -12.3658975 0.05194583 0.11456667 0.0000000 -0.11456667 5.985511e-53 5.985511e-53 FALSE TRUE
ENST00000597270 ENSG00000099783 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPM protein_coding protein_coding 356.9644 457.5611 288.1357 18.43351 3.973676 -0.6671976 20.02705 26.00962 7.389266 11.565491 2.5999930 -1.8141460 0.05249167 0.05536667 0.0257000 -0.02966667 6.749744e-01 5.985511e-53 FALSE TRUE
ENST00000600092 ENSG00000099783 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPM protein_coding protein_coding 356.9644 457.5611 288.1357 18.43351 3.973676 -0.6671976 45.89350 23.95465 56.638207 4.804099 0.8970232 1.2411226 0.13763333 0.05176667 0.1966667 0.14490000 3.224328e-10 5.985511e-53 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000099783 E001 0.000000       19 8444487 8444586 100 +      
ENSG00000099783 E002 0.000000       19 8444587 8444766 180 +      
ENSG00000099783 E003 4.422131 1.206464e-02 7.358890e-01 8.265515e-01 19 8444767 8444919 153 + 0.728 0.691 -0.155
ENSG00000099783 E004 32.635835 1.804188e-02 6.898076e-01 7.916234e-01 19 8444920 8444970 51 + 1.459 1.508 0.169
ENSG00000099783 E005 37.035169 1.397411e-02 6.400019e-01 7.533315e-01 19 8444971 8444974 4 + 1.564 1.539 -0.084
ENSG00000099783 E006 38.728210 1.909374e-02 5.871383e-01 7.104861e-01 19 8444975 8444976 2 + 1.589 1.555 -0.114
ENSG00000099783 E007 309.549807 1.275369e-02 1.682583e-11 3.376698e-10 19 8444977 8444989 13 + 2.684 2.297 -1.289
ENSG00000099783 E008 350.413922 1.146862e-02 2.973797e-11 5.731200e-10 19 8444990 8444991 2 + 2.725 2.364 -1.202
ENSG00000099783 E009 362.631788 9.628635e-03 1.021140e-12 2.503907e-11 19 8444992 8444992 1 + 2.738 2.381 -1.191
ENSG00000099783 E010 423.612781 8.300642e-03 1.337744e-10 2.313810e-09 19 8444993 8444993 1 + 2.775 2.478 -0.987
ENSG00000099783 E011 1487.923538 3.511392e-03 3.233038e-09 4.360285e-08 19 8444994 8445111 118 + 3.247 3.082 -0.547
ENSG00000099783 E012 3286.757941 4.322784e-04 3.595318e-30 6.147312e-28 19 8455405 8455574 170 + 3.562 3.445 -0.390
ENSG00000099783 E013 18.425745 8.825082e-03 8.163499e-02 1.621139e-01 19 8461969 8462528 560 + 1.357 1.217 -0.487
ENSG00000099783 E014 2409.816756 5.174496e-05 1.396171e-37 4.119943e-35 19 8462529 8462581 53 + 3.409 3.323 -0.288
ENSG00000099783 E015 6.447459 4.144296e-03 9.122562e-01 9.483850e-01 19 8462582 8462589 8 + 0.823 0.851 0.108
ENSG00000099783 E016 1523.438634 1.371685e-04 1.355905e-06 1.094564e-05 19 8463497 8463500 4 + 3.178 3.142 -0.121
ENSG00000099783 E017 1642.233985 7.648131e-05 4.295852e-08 4.696383e-07 19 8463501 8463504 4 + 3.212 3.174 -0.126
ENSG00000099783 E018 2233.672809 1.784754e-04 7.665757e-07 6.530509e-06 19 8463593 8463638 46 + 3.341 3.308 -0.112
ENSG00000099783 E019 2434.698543 7.479925e-05 2.060515e-07 1.970015e-06 19 8463639 8463686 48 + 3.375 3.347 -0.092
ENSG00000099783 E020 6.006531 2.717805e-03 8.946226e-01 9.366806e-01 19 8463687 8463852 166 + 0.823 0.820 -0.013
ENSG00000099783 E021 2182.704997 7.655972e-05 1.241155e-03 4.780684e-03 19 8465324 8465362 39 + 3.317 3.304 -0.042
ENSG00000099783 E022 2134.381092 2.084531e-04 1.919616e-04 9.294725e-04 19 8465363 8465479 117 + 3.315 3.291 -0.079
ENSG00000099783 E023 2254.831366 5.064454e-04 4.210001e-03 1.373121e-02 19 8465480 8465515 36 + 3.338 3.315 -0.077
ENSG00000099783 E024 1761.173064 3.527905e-04 6.789807e-02 1.398800e-01 19 8466235 8466248 14 + 3.220 3.213 -0.026
ENSG00000099783 E025 3533.154094 7.730884e-05 1.309847e-01 2.355114e-01 19 8466249 8466388 140 + 3.514 3.519 0.016
ENSG00000099783 E026 2130.393091 4.833490e-05 7.228169e-03 2.181648e-02 19 8467535 8467584 50 + 3.271 3.310 0.131
ENSG00000099783 E027 2060.750786 2.242909e-04 2.751810e-01 4.144550e-01 19 8468774 8468815 42 + 3.265 3.293 0.093
ENSG00000099783 E028 1570.087066 3.087988e-04 3.830017e-01 5.271607e-01 19 8468816 8468834 19 + 3.147 3.175 0.091
ENSG00000099783 E029 2775.464315 8.215936e-04 5.011246e-01 6.372907e-01 19 8471326 8471427 102 + 3.409 3.415 0.019
ENSG00000099783 E030 2509.052603 1.305256e-03 5.541051e-01 6.831262e-01 19 8473664 8473708 45 + 3.365 3.370 0.016
ENSG00000099783 E031 2858.943376 5.720656e-04 4.943641e-03 1.577493e-02 19 8474167 8474244 78 + 3.388 3.442 0.179
ENSG00000099783 E032 3.341597 7.403654e-02 1.549991e-01 2.684154e-01 19 8481469 8481556 88 + 0.763 0.507 -1.116
ENSG00000099783 E033 14.079149 1.279861e-03 8.030637e-01 8.746227e-01 19 8482549 8483157 609 + 1.120 1.158 0.139
ENSG00000099783 E034 1726.371378 9.255465e-05 1.605397e-11 3.231381e-10 19 8483158 8483211 54 + 3.148 3.233 0.283
ENSG00000099783 E035 3249.902001 8.569703e-04 2.263049e-19 1.350749e-17 19 8485603 8485861 259 + 3.369 3.524 0.515
ENSG00000099783 E036 3104.990715 2.318114e-03 2.842007e-08 3.214002e-07 19 8485862 8486157 296 + 3.354 3.502 0.494
ENSG00000099783 E037 3560.253865 5.603571e-04 4.686270e-13 1.212179e-11 19 8486158 8486405 248 + 3.443 3.552 0.360
ENSG00000099783 E038 2420.202104 1.574027e-03 6.053503e-04 2.552966e-03 19 8487024 8487075 52 + 3.291 3.379 0.290
ENSG00000099783 E039 13.406751 2.919545e-02 3.127652e-01 4.552907e-01 19 8487076 8487184 109 + 1.198 1.100 -0.352
ENSG00000099783 E040 32.376805 7.059368e-04 6.975436e-01 7.976456e-01 19 8487302 8488008 707 + 1.466 1.507 0.142
ENSG00000099783 E041 9.253605 2.280222e-03 3.148652e-01 4.576197e-01 19 8488009 8488066 58 + 0.901 1.031 0.485
ENSG00000099783 E042 51.544925 4.492252e-04 9.488256e-04 3.783778e-03 19 8488067 8488690 624 + 1.543 1.741 0.674
ENSG00000099783 E043 5391.409328 1.581128e-03 2.192164e-14 6.861043e-13 19 8488691 8489114 424 + 3.584 3.746 0.538