ENSG00000099341

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000602911 ENSG00000099341 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMD8 protein_coding protein_coding 351.7801 621.577 198.9758 15.83895 5.880327 -1.643291 325.5888 589.5493 177.2171 11.82491 3.561236 -1.734038 0.9148792 0.9487333 0.8912333 -0.0575 0.003094984 8.110167e-17 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000099341 E001 0.000000       19 38374550 38374570 21 +      
ENSG00000099341 E002 70.715449 0.0160955092 1.548266e-01 2.681804e-01 19 38374571 38374757 187 + 1.830 1.723 -0.361
ENSG00000099341 E003 65.348153 0.0175040369 1.196052e-01 2.194029e-01 19 38374758 38374758 1 + 1.810 1.686 -0.419
ENSG00000099341 E004 114.830209 0.0090274420 8.372950e-02 1.653839e-01 19 38374759 38374769 11 + 2.032 1.934 -0.331
ENSG00000099341 E005 118.813686 0.0094272332 1.068194e-01 2.008567e-01 19 38374770 38374771 2 + 2.042 1.950 -0.310
ENSG00000099341 E006 645.760852 0.0060530899 6.389170e-04 2.676297e-03 19 38374772 38374787 16 + 2.808 2.673 -0.448
ENSG00000099341 E007 3094.916374 0.0025700996 1.153441e-02 3.242963e-02 19 38374788 38374961 174 + 3.425 3.372 -0.178
ENSG00000099341 E008 4.152721 0.0048304204 1.074933e-08 1.317735e-07 19 38375009 38375056 48 + 1.126 0.342 -3.364
ENSG00000099341 E009 8.206373 0.0025774148 2.792419e-09 3.814374e-08 19 38375057 38375292 236 + 1.304 0.646 -2.481
ENSG00000099341 E010 4.719040 0.0262838680 5.226610e-08 5.614457e-07 19 38375293 38375387 95 + 1.164 0.376 -3.305
ENSG00000099341 E011 6.232510 0.0233030641 3.494858e-05 2.043489e-04 19 38375388 38375461 74 + 1.145 0.576 -2.227
ENSG00000099341 E012 5.539957 0.0095278817 1.041868e-03 4.103704e-03 19 38375462 38375509 48 + 1.037 0.593 -1.759
ENSG00000099341 E013 1580.181119 0.0009265495 1.634882e-01 2.796929e-01 19 38376160 38376163 4 + 3.105 3.087 -0.062
ENSG00000099341 E014 2848.967019 0.0005694669 2.026500e-02 5.204136e-02 19 38376164 38376232 69 + 3.366 3.341 -0.081
ENSG00000099341 E015 7.685018 0.0623551414 7.569074e-01 8.418884e-01 19 38376233 38376247 15 + 0.774 0.845 0.278
ENSG00000099341 E016 3.421552 0.0049984601 9.604648e-01 9.790908e-01 19 38376248 38376351 104 + 0.540 0.553 0.060
ENSG00000099341 E017 3592.576817 0.0007208882 8.415642e-01 9.011800e-01 19 38376352 38376454 103 + 3.443 3.448 0.015
ENSG00000099341 E018 5149.822539 0.0001227722 6.186374e-01 7.362163e-01 19 38379240 38379405 166 + 3.594 3.605 0.035
ENSG00000099341 E019 4235.264811 0.0003653669 3.167933e-01 4.595934e-01 19 38380899 38380999 101 + 3.504 3.522 0.060
ENSG00000099341 E020 5.337748 0.0233072664 9.521003e-02 1.831919e-01 19 38381000 38381148 149 + 0.455 0.772 1.408
ENSG00000099341 E021 1.911262 0.0078914495 7.868376e-01 8.635035e-01 19 38381149 38381312 164 + 0.350 0.405 0.320
ENSG00000099341 E022 4577.691277 0.0011642046 4.038338e-01 5.476149e-01 19 38382117 38382228 112 + 3.535 3.556 0.071
ENSG00000099341 E023 29.946818 0.0007238651 2.891753e-07 2.685855e-06 19 38382229 38382237 9 + 1.640 1.294 -1.189
ENSG00000099341 E024 47.506222 0.0004728032 9.829598e-12 2.050416e-10 19 38382238 38382445 208 + 1.850 1.484 -1.243
ENSG00000099341 E025 29.809909 0.0006544272 1.720340e-03 6.346403e-03 19 38382446 38382598 153 + 1.551 1.334 -0.749
ENSG00000099341 E026 31.138636 0.0006819293 1.732207e-04 8.492349e-04 19 38382599 38382847 249 + 1.594 1.341 -0.872
ENSG00000099341 E027 2338.111580 0.0015075108 1.198769e-01 2.198015e-01 19 38383253 38383256 4 + 3.228 3.268 0.132
ENSG00000099341 E028 5471.276609 0.0012494528 1.449715e-05 9.277578e-05 19 38383257 38383824 568 + 3.566 3.643 0.258