ENSG00000099331

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397274 ENSG00000099331 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO9B protein_coding protein_coding 16.61633 23.85389 10.44624 1.217664 0.5213961 -1.190464 2.1950568 3.5828020 0.7697482 0.46726052 0.7697482 -2.20402916 0.13418750 0.150466667 0.07843333 -0.07203333 2.097399e-01 4.835773e-22 FALSE TRUE
ENST00000594971 ENSG00000099331 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO9B protein_coding protein_coding 16.61633 23.85389 10.44624 1.217664 0.5213961 -1.190464 0.2657690 0.1981360 0.6451350 0.02369979 0.1363984 1.65426583 0.02100833 0.008433333 0.06306667 0.05463333 2.825728e-05 4.835773e-22 FALSE FALSE
ENST00000597073 ENSG00000099331 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO9B protein_coding protein_coding 16.61633 23.85389 10.44624 1.217664 0.5213961 -1.190464 2.4813909 7.1733777 0.0000000 0.72478082 0.0000000 -9.48851857 0.10659167 0.304600000 0.00000000 -0.30460000 4.835773e-22 4.835773e-22 FALSE TRUE
ENST00000599420 ENSG00000099331 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO9B protein_coding retained_intron 16.61633 23.85389 10.44624 1.217664 0.5213961 -1.190464 1.2933937 0.8173546 0.8325392 0.17418276 0.1930306 0.02623793 0.08457917 0.034333333 0.07890000 0.04456667 1.242864e-01 4.835773e-22 FALSE FALSE
ENST00000682292 ENSG00000099331 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO9B protein_coding protein_coding 16.61633 23.85389 10.44624 1.217664 0.5213961 -1.190464 1.5176101 1.6348360 1.6233239 0.64863747 0.8159839 -0.01013288 0.08507917 0.066733333 0.15090000 0.08416667 9.120543e-01 4.835773e-22 FALSE TRUE
MSTRG.16660.1 ENSG00000099331 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO9B protein_coding   16.61633 23.85389 10.44624 1.217664 0.5213961 -1.190464 2.6289920 2.8975540 2.4487704 0.51574401 0.5005195 -0.24186896 0.18127500 0.120233333 0.23783333 0.11760000 1.653460e-01 4.835773e-22 FALSE TRUE
MSTRG.16660.10 ENSG00000099331 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO9B protein_coding   16.61633 23.85389 10.44624 1.217664 0.5213961 -1.190464 3.1372887 5.5146257 1.2238219 0.36543271 0.6203514 -2.16274260 0.16532083 0.231066667 0.11350000 -0.11756667 6.163305e-01 4.835773e-22 FALSE TRUE
MSTRG.16660.2 ENSG00000099331 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO9B protein_coding   16.61633 23.85389 10.44624 1.217664 0.5213961 -1.190464 0.2778888 0.0000000 0.7764386 0.00000000 0.4028217 6.29726224 0.02687083 0.000000000 0.07806667 0.07806667 1.179270e-01 4.835773e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000099331 E001 0.5858876 0.0226452099 7.248610e-02 1.474892e-01 19 17075759 17075761 3 + 0.389 0.086 -2.725
ENSG00000099331 E002 1.3328556 0.0096765512 3.077573e-04 1.411165e-03 19 17075762 17075776 15 + 0.687 0.086 -4.139
ENSG00000099331 E003 1.4780283 0.0090059810 1.020130e-04 5.312566e-04 19 17075777 17075780 4 + 0.728 0.086 -4.309
ENSG00000099331 E004 1.9219654 0.0071793972 3.614759e-06 2.657889e-05 19 17075781 17075785 5 + 0.832 0.086 -4.724
ENSG00000099331 E005 9.5460401 0.0121720279 4.183684e-09 5.524019e-08 19 17075786 17075874 89 + 1.338 0.676 -2.474
ENSG00000099331 E006 0.1472490 0.0424230446 2.158848e-01   19 17098794 17098838 45 + 0.171 0.000 -13.296
ENSG00000099331 E007 0.5149242 0.2158906101 8.951898e-01 9.370032e-01 19 17101656 17101659 4 + 0.171 0.159 -0.134
ENSG00000099331 E008 14.4149993 0.0807217855 4.325129e-03 1.405556e-02 19 17101660 17101717 58 + 1.393 0.981 -1.469
ENSG00000099331 E009 87.2899656 0.0038627233 2.562708e-09 3.522436e-08 19 17101718 17102181 464 + 2.073 1.801 -0.916
ENSG00000099331 E010 111.0686850 0.0082758571 6.562530e-07 5.670357e-06 19 17102182 17102557 376 + 2.167 1.911 -0.857
ENSG00000099331 E011 9.4991841 0.0018569976 5.858613e-01 7.094938e-01 19 17103257 17103789 533 + 0.916 0.990 0.277
ENSG00000099331 E012 56.4440461 0.0090442678 8.983025e-05 4.741995e-04 19 17145397 17145491 95 + 1.866 1.626 -0.811
ENSG00000099331 E013 47.8809258 0.0099722633 2.608861e-06 1.980132e-05 19 17152644 17152706 63 + 1.839 1.530 -1.052
ENSG00000099331 E014 53.4039776 0.0004467369 1.029965e-08 1.266462e-07 19 17153967 17154066 100 + 1.863 1.593 -0.914
ENSG00000099331 E015 59.4128169 0.0003917923 2.249376e-07 2.135493e-06 19 17154315 17154415 101 + 1.883 1.650 -0.787
ENSG00000099331 E016 75.6246178 0.0003322004 1.868091e-09 2.631454e-08 19 17156909 17157038 130 + 1.989 1.749 -0.810
ENSG00000099331 E017 63.3193727 0.0004588765 7.704827e-08 7.997679e-07 19 17159395 17159484 90 + 1.912 1.677 -0.793
ENSG00000099331 E018 82.6953758 0.0036865294 7.144555e-09 9.044534e-08 19 17162350 17162466 117 + 2.046 1.779 -0.897
ENSG00000099331 E019 85.8872432 0.0007383520 3.109848e-07 2.867664e-06 19 17162988 17163122 135 + 2.018 1.821 -0.664
ENSG00000099331 E020 82.1427312 0.0036562879 1.709104e-06 1.349665e-05 19 17167943 17168064 122 + 2.015 1.794 -0.740
ENSG00000099331 E021 54.8999231 0.0004906771 4.842184e-05 2.738084e-04 19 17172336 17172374 39 + 1.821 1.630 -0.644
ENSG00000099331 E022 74.9566035 0.0005159363 4.101342e-06 2.974454e-05 19 17172375 17172477 103 + 1.954 1.767 -0.628
ENSG00000099331 E023 52.9385992 0.0004943822 1.111070e-04 5.728835e-04 19 17172759 17172812 54 + 1.805 1.621 -0.621
ENSG00000099331 E024 52.5320557 0.0049669703 1.403608e-02 3.830720e-02 19 17172813 17172923 111 + 1.767 1.633 -0.453
ENSG00000099331 E025 35.8744596 0.0073801864 6.959055e-01 7.963785e-01 19 17172924 17172963 40 + 1.517 1.504 -0.045
ENSG00000099331 E026 45.7813394 0.0005043105 8.934169e-03 2.611398e-02 19 17175663 17175741 79 + 1.705 1.573 -0.449
ENSG00000099331 E027 2.5046373 0.0061122374 8.649020e-01 9.169376e-01 19 17177797 17177886 90 + 0.467 0.505 0.185
ENSG00000099331 E028 1.3920981 0.0121596236 2.327803e-01 3.657344e-01 19 17180645 17180926 282 + 0.171 0.404 1.669
ENSG00000099331 E029 65.5318274 0.0003841356 1.121315e-03 4.374763e-03 19 17180927 17181040 114 + 1.863 1.724 -0.468
ENSG00000099331 E030 0.0000000       19 17183737 17183828 92 +      
ENSG00000099331 E031 53.1902451 0.0004301094 2.356296e-04 1.115286e-03 19 17183829 17183868 40 + 1.801 1.628 -0.587
ENSG00000099331 E032 1.6326496 0.0095547601 1.188368e-02 3.325300e-02 19 17183869 17184002 134 + 0.642 0.220 -2.360
ENSG00000099331 E033 2.4357437 0.0061394386 3.261630e-04 1.485530e-03 19 17184511 17184864 354 + 0.832 0.273 -2.724
ENSG00000099331 E034 90.3609952 0.0034818582 1.559304e-02 4.183206e-02 19 17184865 17184987 123 + 1.976 1.874 -0.345
ENSG00000099331 E035 69.6379812 0.0074535907 1.286501e-02 3.559956e-02 19 17185921 17186001 81 + 1.891 1.754 -0.462
ENSG00000099331 E036 78.1907009 0.0065346039 7.861023e-01 8.630053e-01 19 17187935 17188045 111 + 1.845 1.843 -0.007
ENSG00000099331 E037 74.1361935 0.0012749227 6.460146e-01 7.580539e-01 19 17191097 17191219 123 + 1.795 1.829 0.116
ENSG00000099331 E038 136.2022872 0.0065994579 8.740693e-01 9.230304e-01 19 17192746 17193062 317 + 2.065 2.090 0.084
ENSG00000099331 E039 349.9000369 0.0034218979 6.127874e-01 7.316535e-01 19 17194556 17195473 918 + 2.490 2.492 0.007
ENSG00000099331 E040 84.1013572 0.0066131931 3.335598e-01 4.773019e-01 19 17197792 17197858 67 + 1.899 1.863 -0.122
ENSG00000099331 E041 1.9478708 0.0849672500 3.756167e-01 5.200308e-01 19 17198118 17198183 66 + 0.533 0.369 -0.848
ENSG00000099331 E042 100.5441077 0.0004382327 5.166971e-01 6.512323e-01 19 17198184 17198308 125 + 1.958 1.944 -0.046
ENSG00000099331 E043 102.8348386 0.0006774843 6.210541e-01 7.380722e-01 19 17200293 17200426 134 + 1.965 1.957 -0.025
ENSG00000099331 E044 161.1330158 0.0023020581 5.577934e-01 6.861376e-01 19 17200639 17200829 191 + 2.164 2.155 -0.030
ENSG00000099331 E045 144.5716750 0.0002771410 3.484940e-01 4.927245e-01 19 17201926 17202024 99 + 2.123 2.104 -0.063
ENSG00000099331 E046 0.3697384 0.0249821992 5.262208e-01 6.594713e-01 19 17202129 17202129 1 + 0.000 0.158 11.842
ENSG00000099331 E047 186.9774611 0.0002275936 6.771371e-02 1.395594e-01 19 17202130 17202303 174 + 2.172 2.238 0.218
ENSG00000099331 E048 38.7706791 0.0005789808 4.598963e-01 5.999635e-01 19 17202842 17202844 3 + 1.497 1.555 0.199
ENSG00000099331 E049 81.6822818 0.0003922172 1.313633e-01 2.360444e-01 19 17202845 17202869 25 + 1.801 1.880 0.265
ENSG00000099331 E050 78.6942636 0.0004208129 3.078747e-01 4.501049e-01 19 17202870 17202883 14 + 1.805 1.862 0.193
ENSG00000099331 E051 7.4920479 0.0360764263 2.148150e-02 5.460798e-02 19 17202884 17203004 121 + 1.084 0.768 -1.193
ENSG00000099331 E052 5.1637016 0.0036852770 2.534944e-02 6.259123e-02 19 17203005 17203146 142 + 0.941 0.654 -1.139
ENSG00000099331 E053 133.1412372 0.0002900071 3.969828e-03 1.305771e-02 19 17203147 17203258 112 + 1.987 2.101 0.381
ENSG00000099331 E054 101.9452542 0.0003226819 2.876752e-02 6.953823e-02 19 17205263 17205336 74 + 1.885 1.984 0.333
ENSG00000099331 E055 141.3093466 0.0008486583 1.948696e-04 9.421327e-04 19 17205960 17206152 193 + 1.987 2.136 0.499
ENSG00000099331 E056 126.4742490 0.0080519831 9.220022e-03 2.683441e-02 19 17206248 17206376 129 + 1.934 2.092 0.531
ENSG00000099331 E057 54.0376999 0.0163948927 8.077491e-02 1.607547e-01 19 17206679 17206688 10 + 1.576 1.727 0.513
ENSG00000099331 E058 118.9384824 0.0004601672 7.695029e-04 3.148188e-03 19 17206689 17206773 85 + 1.920 2.060 0.470
ENSG00000099331 E059 75.4259663 0.0003780860 3.251770e-02 7.684033e-02 19 17206774 17206784 11 + 1.749 1.859 0.373
ENSG00000099331 E060 0.2987644 0.0269577648 5.783992e-02   19 17206785 17206828 44 + 0.294 0.000 -14.385
ENSG00000099331 E061 144.6526997 0.0003789742 7.278371e-04 2.999033e-03 19 17207113 17207212 100 + 2.014 2.142 0.429
ENSG00000099331 E062 114.5823351 0.0002841124 3.251724e-04 1.481659e-03 19 17207213 17207244 32 + 1.896 2.046 0.503
ENSG00000099331 E063 156.8809881 0.0002460710 6.844294e-05 3.726272e-04 19 17209586 17209709 124 + 2.036 2.179 0.477
ENSG00000099331 E064 101.5097095 0.0019551331 8.077466e-03 2.397678e-02 19 17210333 17210380 48 + 1.857 1.990 0.448
ENSG00000099331 E065 2.6676712 0.0128600804 1.090526e-03 4.271797e-03 19 17210443 17210590 148 + 0.832 0.321 -2.402
ENSG00000099331 E066 2.4097048 0.0073133507 2.140109e-02 5.443427e-02 19 17210591 17210714 124 + 0.728 0.365 -1.724
ENSG00000099331 E067 156.4575620 0.0002392238 7.647434e-07 6.516365e-06 19 17210715 17210848 134 + 2.004 2.181 0.594
ENSG00000099331 E068 0.4031496 0.0242135098 5.259457e-01 6.592442e-01 19 17210849 17210852 4 + 0.000 0.158 11.847
ENSG00000099331 E069 74.2285828 0.0030268706 4.889610e-06 3.489122e-05 19 17211647 17211650 4 + 1.603 1.877 0.927
ENSG00000099331 E070 111.6673848 0.0003352765 5.471036e-10 8.518009e-09 19 17211651 17211774 124 + 1.784 2.052 0.901
ENSG00000099331 E071 34.0454079 0.0219557118 2.571926e-03 8.979793e-03 19 17211775 17211786 12 + 1.240 1.562 1.114
ENSG00000099331 E072 40.6851474 0.0005907900 4.971074e-07 4.398052e-06 19 17211787 17211894 108 + 1.276 1.637 1.246
ENSG00000099331 E073 592.9941249 0.0057419826 4.718497e-14 1.405953e-12 19 17211895 17213295 1401 + 2.479 2.788 1.030
ENSG00000099331 E074 0.5159433 0.1883019067 2.577558e-01 3.949283e-01 19 17214460 17214594 135 + 0.293 0.087 -2.119