ENSG00000099326

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000215057 ENSG00000099326 HEK293_OSMI2_2hA HEK293_TMG_2hB MZF1 protein_coding protein_coding 9.862825 13.00848 6.099242 1.085539 0.3002613 -1.091495 2.5373771 4.9628864 1.6706899 0.15928147 0.07674145 -1.5650299 0.26886250 0.38493333 0.27440000 -0.11053333 0.0436191811 6.849875e-06 FALSE TRUE
ENST00000595245 ENSG00000099326 HEK293_OSMI2_2hA HEK293_TMG_2hB MZF1 protein_coding retained_intron 9.862825 13.00848 6.099242 1.085539 0.3002613 -1.091495 0.4472649 0.1206539 0.3806767 0.02951761 0.04737221 1.5802255 0.04930417 0.00970000 0.06340000 0.05370000 0.0001778562 6.849875e-06 TRUE TRUE
ENST00000600004 ENSG00000099326 HEK293_OSMI2_2hA HEK293_TMG_2hB MZF1 protein_coding retained_intron 9.862825 13.00848 6.099242 1.085539 0.3002613 -1.091495 4.3759091 5.5383786 2.3423020 0.64380044 0.20441345 -1.2379929 0.41640833 0.42386667 0.38270000 -0.04116667 0.6355588921 6.849875e-06 FALSE TRUE
MSTRG.17870.7 ENSG00000099326 HEK293_OSMI2_2hA HEK293_TMG_2hB MZF1 protein_coding   9.862825 13.00848 6.099242 1.085539 0.3002613 -1.091495 1.3332965 1.2195512 0.8486047 0.28438366 0.06703993 -0.5180659 0.13833750 0.09296667 0.13873333 0.04576667 0.3579240162 6.849875e-06 FALSE TRUE
MSTRG.17870.9 ENSG00000099326 HEK293_OSMI2_2hA HEK293_TMG_2hB MZF1 protein_coding   9.862825 13.00848 6.099242 1.085539 0.3002613 -1.091495 0.4803984 0.2734973 0.5132739 0.07524663 0.08053405 0.8842313 0.05570417 0.02043333 0.08363333 0.06320000 0.0004932805 6.849875e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000099326 E001 0.6934063 0.1814227131 2.111070e-01 3.398328e-01 19 58561090 58561930 841 - 0.000 0.277 10.379
ENSG00000099326 E002 0.6934063 0.1814227131 2.111070e-01 3.398328e-01 19 58561931 58561931 1 - 0.000 0.277 12.315
ENSG00000099326 E003 1.2448491 0.0235111302 4.220331e-02 9.509938e-02 19 58561932 58561932 1 - 0.000 0.409 13.858
ENSG00000099326 E004 309.8584824 0.0020532153 1.115625e-14 3.643996e-13 19 58561933 58563260 1328 - 2.277 2.494 0.725
ENSG00000099326 E005 103.5039899 0.0007941238 2.816249e-06 2.121475e-05 19 58563261 58563504 244 - 1.819 2.015 0.658
ENSG00000099326 E006 133.6842413 0.0010143070 3.633526e-01 5.077641e-01 19 58563505 58564613 1109 - 2.049 2.085 0.121
ENSG00000099326 E007 22.0508474 0.0009156117 5.304914e-02 1.145678e-01 19 58566315 58566701 387 - 1.409 1.266 -0.500
ENSG00000099326 E008 17.0936466 0.0018057595 1.968432e-02 5.081811e-02 19 58566702 58566896 195 - 1.340 1.145 -0.686
ENSG00000099326 E009 73.0350525 0.0098826700 2.505343e-04 1.177537e-03 19 58566897 58568166 1270 - 1.964 1.748 -0.730
ENSG00000099326 E010 58.8258219 0.0026412369 3.405572e-10 5.487119e-09 19 58568167 58569204 1038 - 1.926 1.614 -1.056
ENSG00000099326 E011 8.1907135 0.0022593915 1.423343e-02 3.875756e-02 19 58569205 58569276 72 - 1.093 0.819 -1.026
ENSG00000099326 E012 43.1161152 0.0005688026 1.993165e-02 5.134261e-02 19 58569277 58569333 57 - 1.483 1.627 0.493
ENSG00000099326 E013 49.0721977 0.0005829267 7.585009e-02 1.528629e-01 19 58569334 58569397 64 - 1.574 1.677 0.349
ENSG00000099326 E014 3.1499473 0.1545500407 4.487258e-01 5.899891e-01 19 58569398 58569415 18 - 0.679 0.521 -0.705
ENSG00000099326 E015 47.2368112 0.0005043344 5.738549e-01 6.997670e-01 19 58569516 58569586 71 - 1.606 1.640 0.118
ENSG00000099326 E016 6.1645745 0.0027258798 3.396888e-08 3.787288e-07 19 58569587 58570343 757 - 1.182 0.510 -2.671
ENSG00000099326 E017 67.5533272 0.0005123534 1.627059e-01 2.786882e-01 19 58570344 58570527 184 - 1.729 1.799 0.236
ENSG00000099326 E018 13.5000706 0.0034752402 9.903797e-08 1.006353e-06 19 58570528 58570993 466 - 1.401 0.912 -1.756
ENSG00000099326 E019 49.2261475 0.0004887865 3.410737e-01 4.849841e-01 19 58570994 58571161 168 - 1.611 1.666 0.188
ENSG00000099326 E020 25.5816118 0.0008402952 7.896359e-01 8.653914e-01 19 58571162 58571199 38 - 1.384 1.368 -0.055
ENSG00000099326 E021 71.0625043 0.0003659117 9.668253e-01 9.832097e-01 19 58571200 58571429 230 - 1.803 1.805 0.006
ENSG00000099326 E022 23.7911387 0.0044080194 7.142101e-13 1.794496e-11 19 58571430 58572549 1120 - 1.654 1.117 -1.866
ENSG00000099326 E023 10.0566161 0.0187140189 4.826424e-03 1.544774e-02 19 58572550 58572719 170 - 1.209 0.875 -1.224
ENSG00000099326 E024 6.7841229 0.0999963594 4.839095e-03 1.548280e-02 19 58572720 58573054 335 - 1.140 0.643 -1.915
ENSG00000099326 E025 34.1550872 0.0011029526 2.050538e-02 5.255423e-02 19 58573055 58573372 318 - 1.596 1.455 -0.482
ENSG00000099326 E026 31.8687803 0.0006731189 3.090141e-02 7.372465e-02 19 58573373 58574797 1425 - 1.557 1.423 -0.461