ENSG00000099290

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282633 ENSG00000099290 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC2A protein_coding protein_coding 17.92994 13.68872 20.30728 0.7113447 0.4862134 0.568666 10.1114952 5.3021694 11.6567969 1.73477936 0.3818484 1.135035 0.54450833 0.38026667 0.57550000 0.19523333 0.368014828 0.008667047 FALSE TRUE
ENST00000351071 ENSG00000099290 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC2A protein_coding protein_coding 17.92994 13.68872 20.30728 0.7113447 0.4862134 0.568666 1.6515998 1.6212450 3.2859677 0.34828010 0.4840449 1.014729 0.09308333 0.12153333 0.16260000 0.04106667 0.678725323 0.008667047 FALSE TRUE
ENST00000399339 ENSG00000099290 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC2A protein_coding protein_coding 17.92994 13.68872 20.30728 0.7113447 0.4862134 0.568666 2.3951456 5.4849609 0.8213061 0.90115325 0.8213061 -2.724657 0.16108750 0.40530000 0.03880000 -0.36650000 0.033507641 0.008667047 FALSE TRUE
ENST00000454806 ENSG00000099290 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC2A protein_coding protein_coding 17.92994 13.68872 20.30728 0.7113447 0.4862134 0.568666 0.9740854 0.2101373 1.3980041 0.07144651 0.2911442 2.677176 0.05477500 0.01580000 0.06963333 0.05383333 0.008667047 0.008667047 FALSE TRUE
ENST00000492914 ENSG00000099290 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC2A protein_coding processed_transcript 17.92994 13.68872 20.30728 0.7113447 0.4862134 0.568666 1.0172774 0.2353536 1.2546718 0.07681045 0.6273412 2.365829 0.05020417 0.01673333 0.06060000 0.04386667 0.828889201 0.008667047   TRUE
ENST00000611324 ENSG00000099290 HEK293_OSMI2_2hA HEK293_TMG_2hB WASHC2A protein_coding protein_coding 17.92994 13.68872 20.30728 0.7113447 0.4862134 0.568666 1.0765366 0.4827499 1.3970618 0.25404785 0.2429010 1.513758 0.05877917 0.03466667 0.06840000 0.03373333 0.556105445 0.008667047 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000099290 E001 0.0000000       10 50067302 50067418 117 +      
ENSG00000099290 E002 0.0000000       10 50067419 50067543 125 +      
ENSG00000099290 E003 0.0000000       10 50067544 50067887 344 +      
ENSG00000099290 E004 0.2987644 0.0272292124 2.990145e-01   10 50067888 50067906 19 + 0.187 0.000 -10.466
ENSG00000099290 E005 2.9946500 0.0052828409 5.329251e-02 1.150108e-01 10 50067907 50067922 16 + 0.703 0.410 -1.361
ENSG00000099290 E006 3.8083255 0.0040487541 8.005966e-02 1.596493e-01 10 50067923 50067923 1 + 0.767 0.526 -1.039
ENSG00000099290 E007 11.1729016 0.0015723126 5.423987e-03 1.708042e-02 10 50067924 50067953 30 + 1.184 0.928 -0.935
ENSG00000099290 E008 28.2754670 0.0052950174 1.318615e-04 6.670253e-04 10 50067954 50068008 55 + 1.566 1.306 -0.896
ENSG00000099290 E009 0.1472490 0.0434228888 6.482301e-01   10 50068009 50068104 96 + 0.104 0.000 -9.464
ENSG00000099290 E010 45.4473994 0.0127299211 9.268429e-04 3.708997e-03 10 50068105 50068227 123 + 1.751 1.525 -0.772
ENSG00000099290 E011 0.9233738 0.0143738412 6.529307e-01 7.635353e-01 10 50069510 50069546 37 + 0.318 0.252 -0.456
ENSG00000099290 E012 83.7835366 0.0044592992 3.419781e-04 1.548181e-03 10 50069547 50069711 165 + 1.988 1.837 -0.509
ENSG00000099290 E013 0.0000000       10 50078126 50078152 27 +      
ENSG00000099290 E014 47.7948714 0.0005521868 5.904919e-04 2.498870e-03 10 50078675 50078692 18 + 1.746 1.597 -0.505
ENSG00000099290 E015 48.1968620 0.0004966223 1.480437e-03 5.573948e-03 10 50078693 50078737 45 + 1.744 1.610 -0.454
ENSG00000099290 E016 40.6252367 0.0005575432 1.011482e-06 8.380227e-06 10 50080758 50080875 118 + 1.715 1.467 -0.847
ENSG00000099290 E017 20.7951721 0.0037952861 5.782075e-02 1.228933e-01 10 50080876 50080931 56 + 1.393 1.271 -0.424
ENSG00000099290 E018 42.0204818 0.0062346769 1.956147e-01 3.207345e-01 10 50084072 50084165 94 + 1.660 1.607 -0.179
ENSG00000099290 E019 55.7095177 0.0004149889 1.768537e-03 6.499273e-03 10 50085497 50085558 62 + 1.805 1.686 -0.400
ENSG00000099290 E020 0.0000000       10 50085559 50085619 61 +      
ENSG00000099290 E021 69.1297110 0.0004069344 1.179626e-04 6.045136e-04 10 50087275 50087322 48 + 1.904 1.769 -0.455
ENSG00000099290 E022 99.3606631 0.0006041438 6.315765e-07 5.476235e-06 10 50090776 50090886 111 + 2.067 1.913 -0.515
ENSG00000099290 E023 67.2021944 0.0004017550 5.359528e-05 2.997333e-04 10 50091431 50091518 88 + 1.892 1.745 -0.496
ENSG00000099290 E024 55.2866272 0.0004109521 2.004265e-02 5.157804e-02 10 50092162 50092233 72 + 1.784 1.704 -0.272
ENSG00000099290 E025 55.7678198 0.0004706007 5.450521e-02 1.171289e-01 10 50093268 50093386 119 + 1.778 1.717 -0.207
ENSG00000099290 E026 43.6769822 0.0011475932 7.029857e-04 2.909798e-03 10 50093860 50093917 58 + 1.711 1.552 -0.541
ENSG00000099290 E027 46.9304478 0.0190520142 4.366445e-02 9.776856e-02 10 50095148 50095207 60 + 1.734 1.590 -0.489
ENSG00000099290 E028 88.5519962 0.0047109878 1.561064e-04 7.743070e-04 10 50095599 50095778 180 + 2.015 1.854 -0.541
ENSG00000099290 E029 83.1084619 0.0003307749 6.622592e-05 3.618882e-04 10 50097675 50097802 128 + 1.975 1.849 -0.426
ENSG00000099290 E030 56.3385947 0.0004435931 8.661359e-02 1.699836e-01 10 50099978 50100064 87 + 1.780 1.730 -0.170
ENSG00000099290 E031 68.5913321 0.0004904985 2.555133e-01 3.924108e-01 10 50104042 50104143 102 + 1.850 1.831 -0.062
ENSG00000099290 E032 67.6242890 0.0005488075 3.873664e-01 5.315048e-01 10 50106334 50106465 132 + 1.836 1.829 -0.025
ENSG00000099290 E033 81.0589505 0.0003803559 4.445373e-01 5.860887e-01 10 50110101 50110270 170 + 1.911 1.912 0.001
ENSG00000099290 E034 37.5555603 0.0005664932 1.154975e-01 2.135662e-01 10 50113895 50113997 103 + 1.611 1.551 -0.205
ENSG00000099290 E035 19.3269986 0.0010461855 3.184656e-01 4.614365e-01 10 50117906 50118058 153 + 1.248 1.355 0.373
ENSG00000099290 E036 12.8690629 0.0027608681 1.001016e-01 1.906314e-01 10 50119587 50119649 63 + 1.040 1.224 0.659
ENSG00000099290 E037 45.6640245 0.0006534021 3.232398e-01 4.665554e-01 10 50119650 50119769 120 + 1.626 1.707 0.277
ENSG00000099290 E038 62.3744380 0.0004152876 3.465620e-01 4.906814e-01 10 50125113 50125241 129 + 1.764 1.836 0.244
ENSG00000099290 E039 44.1009124 0.0075420421 9.958909e-01 1.000000e+00 10 50125369 50125449 81 + 1.640 1.668 0.096
ENSG00000099290 E040 55.6839952 0.0004755049 5.134816e-01 6.483052e-01 10 50126057 50126179 123 + 1.752 1.751 -0.002
ENSG00000099290 E041 6.1603847 0.0051730066 2.815909e-04 1.304891e-03 10 50126180 50126508 329 + 1.007 0.526 -1.956
ENSG00000099290 E042 24.0385478 0.0007920845 3.489162e-01 4.931248e-01 10 50127160 50127222 63 + 1.348 1.443 0.329
ENSG00000099290 E043 35.2498446 0.0090689536 8.195923e-01 8.860886e-01 10 50127583 50127795 213 + 1.556 1.572 0.053
ENSG00000099290 E044 91.2096105 0.0006952149 2.616090e-02 6.427318e-02 10 50129419 50129644 226 + 1.910 2.025 0.386
ENSG00000099290 E045 124.3733230 0.0024297909 6.363753e-02 1.327571e-01 10 50129645 50129784 140 + 2.048 2.150 0.340
ENSG00000099290 E046 108.3454243 0.0084371407 5.259172e-02 1.137731e-01 10 50129785 50129857 73 + 1.969 2.104 0.452
ENSG00000099290 E047 149.5314829 0.0048012610 1.210600e-02 3.378974e-02 10 50129858 50130039 182 + 2.106 2.242 0.456
ENSG00000099290 E048 111.5467355 0.0003936443 1.138850e-07 1.144876e-06 10 50130901 50131078 178 + 1.943 2.153 0.702
ENSG00000099290 E049 142.0896317 0.0102718353 2.286351e-06 1.755816e-05 10 50132806 50132955 150 + 1.998 2.291 0.981
ENSG00000099290 E050 62.5056217 0.0174710755 8.039651e-04 3.273064e-03 10 50132956 50132989 34 + 1.648 1.939 0.984
ENSG00000099290 E051 207.9502436 0.0061439119 1.951778e-14 6.158537e-13 10 50132990 50133437 448 + 2.117 2.481 1.214
ENSG00000099290 E052 13.7379299 0.0551532161 9.011421e-03 2.630772e-02 10 50133438 50133509 72 + 0.946 1.342 1.422
ENSG00000099290 E053 1.1103491 0.4602101708 8.800607e-01 9.270810e-01 10 50134153 50134302 150 + 0.258 0.355 0.646