ENSG00000099219

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000214893 ENSG00000099219 HEK293_OSMI2_2hA HEK293_TMG_2hB ERMP1 protein_coding retained_intron 4.759598 3.148971 4.833148 0.3907826 0.1103448 0.6164903 2.5024504 2.0973515 1.8431292 0.4498537 0.2548390 -0.1854675 0.5469667 0.6530667 0.3795667 -0.2735000 3.641301e-02 4.64246e-13 FALSE TRUE
ENST00000339450 ENSG00000099219 HEK293_OSMI2_2hA HEK293_TMG_2hB ERMP1 protein_coding protein_coding 4.759598 3.148971 4.833148 0.3907826 0.1103448 0.6164903 0.7539796 0.0000000 1.5233756 0.0000000 0.1838367 7.2605673 0.1302000 0.0000000 0.3168000 0.3168000 4.642460e-13 4.64246e-13 FALSE TRUE
ENST00000691251 ENSG00000099219 HEK293_OSMI2_2hA HEK293_TMG_2hB ERMP1 protein_coding protein_coding 4.759598 3.148971 4.833148 0.3907826 0.1103448 0.6164903 0.7613290 0.5109429 0.2659816 0.2554763 0.2659816 -0.9165530 0.1677750 0.1830667 0.0544000 -0.1286667 5.297843e-01 4.64246e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000099219 E001 0.0000000       9 5749832 5749978 147 -      
ENSG00000099219 E002 0.1817044 0.0401831468 3.370351e-01   9 5749979 5750873 895 - 0.000 0.150 10.114
ENSG00000099219 E003 0.0000000       9 5750874 5750876 3 -      
ENSG00000099219 E004 0.7728880 0.0180145802 1.448534e-02 3.932731e-02 9 5764015 5764151 137 - 0.000 0.423 14.473
ENSG00000099219 E005 0.5514428 0.0201527381 4.019765e-02 9.139962e-02 9 5764152 5764152 1 - 0.000 0.349 14.077
ENSG00000099219 E006 0.5514428 0.0201527381 4.019765e-02 9.139962e-02 9 5764153 5764210 58 - 0.000 0.349 14.077
ENSG00000099219 E007 0.9631001 0.5293259661 6.342099e-01 7.487529e-01 9 5764211 5764276 66 - 0.181 0.368 1.367
ENSG00000099219 E008 4.4683155 0.0186229617 4.361489e-02 9.767284e-02 9 5764277 5764697 421 - 0.554 0.881 1.355
ENSG00000099219 E009 2.4431134 0.0388487989 9.442511e-02 1.820144e-01 9 5764698 5765075 378 - 0.360 0.674 1.527
ENSG00000099219 E010 3.7739668 0.2789421366 8.720584e-01 9.217186e-01 9 5765076 5765788 713 - 0.639 0.693 0.231
ENSG00000099219 E011 3.3006945 0.1957919051 9.643892e-02 1.850133e-01 9 5779009 5779055 47 - 0.407 0.806 1.799
ENSG00000099219 E012 0.0000000       9 5784561 5784570 10 -      
ENSG00000099219 E013 0.0000000       9 5784571 5784571 1 -      
ENSG00000099219 E014 0.8481309 0.0136968632 3.911332e-01 5.350717e-01 9 5784572 5784582 11 - 0.181 0.349 1.258
ENSG00000099219 E015 1.0298353 0.0120570383 2.053379e-01 3.328512e-01 9 5784583 5784584 2 - 0.181 0.422 1.673
ENSG00000099219 E016 50.4038925 0.0023020843 4.042707e-15 1.410198e-13 9 5784585 5784986 402 - 1.460 1.916 1.548
ENSG00000099219 E017 208.0613557 0.0138819782 5.114624e-03 1.624229e-02 9 5784987 5786642 1656 - 2.232 2.411 0.598
ENSG00000099219 E018 58.7621866 0.0009450279 5.003037e-01 6.365800e-01 9 5786643 5787060 418 - 1.747 1.818 0.239
ENSG00000099219 E019 24.2290890 0.0035324282 2.257671e-01 3.573025e-01 9 5787061 5787173 113 - 1.345 1.473 0.441
ENSG00000099219 E020 24.4268319 0.0008402258 6.587111e-01 7.677452e-01 9 5787174 5787308 135 - 1.379 1.449 0.240
ENSG00000099219 E021 12.1323099 0.0015099480 7.198039e-01 8.145406e-01 9 5787430 5787433 4 - 1.091 1.163 0.257
ENSG00000099219 E022 37.3178719 0.0005872436 6.877338e-01 7.900043e-01 9 5787434 5787593 160 - 1.554 1.616 0.210
ENSG00000099219 E023 0.3697384 0.0253084326 1.160408e-01 2.143025e-01 9 5787594 5788721 1128 - 0.000 0.261 13.501
ENSG00000099219 E024 0.2955422 0.0287712729 7.882174e-01   9 5791234 5791282 49 - 0.100 0.149 0.670
ENSG00000099219 E025 32.8772881 0.0007103684 7.889681e-01 8.648947e-01 9 5797817 5797932 116 - 1.501 1.555 0.187
ENSG00000099219 E026 40.6090090 0.0137331446 7.088446e-01 8.064019e-01 9 5798806 5799008 203 - 1.612 1.613 0.003
ENSG00000099219 E027 28.2505543 0.0019598932 3.925104e-01 5.364763e-01 9 5801176 5801328 153 - 1.419 1.514 0.325
ENSG00000099219 E028 22.4922456 0.0154268965 7.834782e-01 8.610488e-01 9 5805027 5805217 191 - 1.340 1.402 0.217
ENSG00000099219 E029 22.1526742 0.0011064522 4.413590e-04 1.933275e-03 9 5805611 5805785 175 - 1.448 1.220 -0.794
ENSG00000099219 E030 23.5805509 0.0008666486 5.211938e-04 2.239173e-03 9 5810011 5810118 108 - 1.468 1.252 -0.751
ENSG00000099219 E031 17.0212118 0.0010479645 8.119343e-06 5.506104e-05 9 5810119 5810144 26 - 1.374 1.019 -1.263
ENSG00000099219 E032 21.7014519 0.0024038132 1.592181e-04 7.883378e-04 9 5810145 5810231 87 - 1.448 1.187 -0.913
ENSG00000099219 E033 36.3413816 0.0063442680 1.605559e-04 7.944014e-04 9 5811111 5811323 213 - 1.654 1.429 -0.772
ENSG00000099219 E034 25.7386586 0.0008044774 3.296157e-03 1.113831e-02 9 5812125 5812217 93 - 1.490 1.325 -0.571
ENSG00000099219 E035 0.1482932 0.0407971137 3.394146e-01   9 5812737 5812888 152 - 0.000 0.149 12.470
ENSG00000099219 E036 25.8591663 0.0007896966 1.021508e-03 4.033215e-03 9 5812889 5813035 147 - 1.504 1.316 -0.650
ENSG00000099219 E037 0.9921577 0.0127351668 2.069701e-01 3.349008e-01 9 5821918 5823895 1978 - 0.181 0.422 1.672
ENSG00000099219 E038 23.5830005 0.0013698434 2.485393e-02 6.156918e-02 9 5823896 5824001 106 - 1.440 1.316 -0.429
ENSG00000099219 E039 22.5140146 0.0022460507 4.091090e-02 9.272200e-02 9 5825092 5825219 128 - 1.415 1.299 -0.404
ENSG00000099219 E040 0.0000000       9 5825220 5825285 66 -      
ENSG00000099219 E041 27.8303655 0.0122576322 1.262360e-01 2.289134e-01 9 5830727 5831028 302 - 1.494 1.402 -0.316
ENSG00000099219 E042 0.0000000       9 5832454 5832689 236 -      
ENSG00000099219 E043 7.1205162 0.0042187782 1.060888e-02 3.023104e-02 9 5832690 5832817 128 - 1.001 0.709 -1.133
ENSG00000099219 E044 15.0610402 0.0181068258 4.344758e-04 1.907270e-03 9 5832818 5832980 163 - 1.319 0.948 -1.334
ENSG00000099219 E045 11.4644681 0.0140145474 1.498267e-03 5.630339e-03 9 5832981 5833312 332 - 1.203 0.857 -1.270
ENSG00000099219 E046 0.8105550 0.0140115331 3.324206e-01 4.760708e-01 9 5859468 5859611 144 - 0.308 0.150 -1.326
ENSG00000099219 E047 0.2966881 0.0271731608 3.312346e-01   9 5867802 5867902 101 - 0.181 0.000 -13.117
ENSG00000099219 E048 0.5181333 0.0209873312 8.141543e-01 8.822485e-01 9 5872158 5872216 59 - 0.181 0.150 -0.325
ENSG00000099219 E049 0.1472490 0.0439206190 7.040738e-01   9 5874819 5875063 245 - 0.100 0.000 -12.129
ENSG00000099219 E050 0.3030308 0.3764885971 4.406194e-01   9 5875718 5877293 1576 - 0.181 0.000 -12.567
ENSG00000099219 E051 0.2955422 0.0287712729 7.882174e-01   9 5878464 5879537 1074 - 0.100 0.149 0.670