ENSG00000099204

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392952 ENSG00000099204 HEK293_OSMI2_2hA HEK293_TMG_2hB ABLIM1 protein_coding protein_coding 13.59056 11.52036 15.65623 1.517398 0.6013483 0.4422206 9.3987209 9.70497122 9.402386 1.1618070 0.3542245 -0.04564919 0.70858750 0.845733333 0.6006000 -0.24513333 2.265310e-08 8.850157e-12 FALSE TRUE
MSTRG.4676.4 ENSG00000099204 HEK293_OSMI2_2hA HEK293_TMG_2hB ABLIM1 protein_coding   13.59056 11.52036 15.65623 1.517398 0.6013483 0.4422206 1.3405143 0.08300472 2.641086 0.0316663 0.3813971 4.83313581 0.08903750 0.007866667 0.1693667 0.16150000 8.850157e-12 8.850157e-12 FALSE TRUE
MSTRG.4676.9 ENSG00000099204 HEK293_OSMI2_2hA HEK293_TMG_2hB ABLIM1 protein_coding   13.59056 11.52036 15.65623 1.517398 0.6013483 0.4422206 0.7183998 0.24830798 1.140484 0.2005988 0.3915852 2.15507671 0.04810417 0.018533333 0.0719000 0.05336667 2.484305e-01 8.850157e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000099204 E001 1.0297335 0.0124198196 4.198557e-03 1.369972e-02 10 114431112 114431112 1 - 0.000 0.545 12.701
ENSG00000099204 E002 503.0485075 0.0119996189 4.154725e-21 3.029639e-19 10 114431113 114431893 781 - 2.347 2.943 1.986
ENSG00000099204 E003 419.9596831 0.0038086353 1.686962e-20 1.144663e-18 10 114431894 114432615 722 - 2.392 2.815 1.410
ENSG00000099204 E004 888.9236967 0.0033772861 3.982475e-01 5.419834e-01 10 114432616 114435440 2825 - 2.877 3.024 0.487
ENSG00000099204 E005 127.6202737 0.0008951173 4.784213e-07 4.247609e-06 10 114435441 114435953 513 - 2.123 2.088 -0.116
ENSG00000099204 E006 45.0097835 0.0042814322 9.557348e-06 6.382132e-05 10 114435954 114436017 64 - 1.717 1.581 -0.462
ENSG00000099204 E007 64.5825022 0.0005912437 2.697702e-07 2.520076e-06 10 114436018 114436096 79 - 1.855 1.759 -0.322
ENSG00000099204 E008 76.0158810 0.0020131749 6.683249e-07 5.763504e-06 10 114436097 114436177 81 - 1.920 1.827 -0.315
ENSG00000099204 E009 105.4306050 0.0039615183 4.859374e-09 6.355937e-08 10 114436178 114436373 196 - 2.076 1.938 -0.462
ENSG00000099204 E010 46.8399314 0.0014269447 5.568786e-07 4.883760e-06 10 114437844 114437924 81 - 1.733 1.596 -0.466
ENSG00000099204 E011 53.4098161 0.0077266455 4.875628e-05 2.754845e-04 10 114439176 114439250 75 - 1.783 1.652 -0.444
ENSG00000099204 E012 1.9876262 0.0986755135 8.875848e-01 9.321382e-01 10 114439617 114440081 465 - 0.442 0.493 0.256
ENSG00000099204 E013 39.6451128 0.0073599871 6.916551e-04 2.868790e-03 10 114440082 114440089 8 - 1.646 1.538 -0.368
ENSG00000099204 E014 56.6800476 0.0008499510 8.262775e-06 5.594560e-05 10 114441017 114441077 61 - 1.790 1.709 -0.274
ENSG00000099204 E015 52.9759844 0.0004507610 6.798949e-06 4.696764e-05 10 114441722 114441786 65 - 1.765 1.680 -0.287
ENSG00000099204 E016 47.0965386 0.0005245675 3.770344e-07 3.416629e-06 10 114444029 114444085 57 - 1.731 1.601 -0.442
ENSG00000099204 E017 43.4458320 0.0006249600 9.088922e-07 7.613836e-06 10 114444086 114444134 49 - 1.700 1.568 -0.448
ENSG00000099204 E018 64.8372064 0.0004042705 2.581387e-11 5.026223e-10 10 114445312 114445403 92 - 1.880 1.716 -0.553
ENSG00000099204 E019 67.4708673 0.0013752083 3.616266e-15 1.269863e-13 10 114447880 114448020 141 - 1.918 1.676 -0.814
ENSG00000099204 E020 6.2756091 0.0027299589 6.555260e-06 4.543498e-05 10 114448021 114448026 6 - 1.005 0.490 -2.121
ENSG00000099204 E021 0.7644715 0.0809443700 2.755931e-01 4.149238e-01 10 114450079 114450135 57 - 0.303 0.152 -1.270
ENSG00000099204 E022 33.2688107 0.0149413898 8.535757e-07 7.195308e-06 10 114451624 114451644 21 - 1.633 1.333 -1.031
ENSG00000099204 E023 31.2052114 0.0218997881 1.766706e-06 1.390458e-05 10 114451645 114451671 27 - 1.620 1.277 -1.183
ENSG00000099204 E024 1.0006785 0.0244158013 5.640782e-01 6.914546e-01 10 114453379 114453483 105 - 0.304 0.265 -0.271
ENSG00000099204 E025 0.0000000       10 114463045 114463164 120 -      
ENSG00000099204 E026 0.0000000       10 114465465 114465697 233 -      
ENSG00000099204 E027 62.1645023 0.0115658521 5.083258e-07 4.491642e-06 10 114465698 114465827 130 - 1.877 1.662 -0.728
ENSG00000099204 E028 34.3010542 0.0009759032 1.636265e-05 1.035217e-04 10 114468181 114468216 36 - 1.599 1.469 -0.444
ENSG00000099204 E029 0.0000000       10 114468217 114468265 49 -      
ENSG00000099204 E030 70.8793516 0.0040965546 9.755560e-08 9.925680e-07 10 114472977 114473132 156 - 1.911 1.765 -0.492
ENSG00000099204 E031 43.9584613 0.0005238036 2.379643e-06 1.820744e-05 10 114473879 114473956 78 - 1.697 1.578 -0.407
ENSG00000099204 E032 0.0000000       10 114481479 114481526 48 -      
ENSG00000099204 E033 0.1515154 0.0445051773 5.963867e-01   10 114485297 114485380 84 - 0.098 0.000 -11.974
ENSG00000099204 E034 46.4197237 0.0074568565 1.313814e-03 5.023273e-03 10 114487958 114488016 59 - 1.708 1.629 -0.267
ENSG00000099204 E035 48.3081893 0.0077393514 7.112443e-04 2.939037e-03 10 114491791 114491878 88 - 1.729 1.641 -0.298
ENSG00000099204 E036 3.7653730 0.0043140811 8.627189e-01 9.154641e-01 10 114526639 114526659 21 - 0.632 0.715 0.349
ENSG00000099204 E037 52.9137649 0.0032650896 1.969156e-09 2.760885e-08 10 114526660 114526931 272 - 1.806 1.600 -0.697
ENSG00000099204 E038 3.4384959 0.0055008114 8.256308e-01 8.902191e-01 10 114545005 114545098 94 - 0.606 0.678 0.312
ENSG00000099204 E039 0.0000000       10 114547491 114547649 159 -      
ENSG00000099204 E040 4.5642126 0.0034654248 9.522452e-01 9.741084e-01 10 114547650 114547776 127 - 0.703 0.809 0.426
ENSG00000099204 E041 6.0193356 0.0027411266 9.361914e-01 9.638512e-01 10 114571297 114571406 110 - 0.800 0.909 0.421
ENSG00000099204 E042 5.9505518 0.0106887408 4.793275e-01 6.177105e-01 10 114575416 114575599 184 - 0.834 0.861 0.106
ENSG00000099204 E043 0.0000000       10 114595002 114595133 132 -      
ENSG00000099204 E044 4.6531732 0.0053586507 3.417971e-01 4.857356e-01 10 114601827 114601961 135 - 0.764 0.748 -0.064
ENSG00000099204 E045 0.0000000       10 114610629 114610717 89 -      
ENSG00000099204 E046 1.0393897 0.0120272295 7.573951e-03 2.270388e-02 10 114631902 114632092 191 - 0.443 0.000 -15.176
ENSG00000099204 E047 0.0000000       10 114657957 114658283 327 -      
ENSG00000099204 E048 0.0000000       10 114684290 114685003 714 -      
ENSG00000099204 E049 1.3942776 0.0096227614 9.548230e-01 9.756759e-01 10 114768061 114768061 1 - 0.355 0.427 0.404