ENSG00000097046

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000234626 ENSG00000097046 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC7 protein_coding protein_coding 29.72149 10.44708 46.14987 0.7420775 1.445339 2.142159 21.1766990 5.8935687 34.4653864 0.4008593 1.71923377 2.5459075 0.6912417 0.56506667 0.74603333 0.18096667 3.213887e-05 2.094983e-20 FALSE TRUE
ENST00000428239 ENSG00000097046 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC7 protein_coding protein_coding 29.72149 10.44708 46.14987 0.7420775 1.445339 2.142159 2.5773837 1.5096886 3.1459367 0.3158007 0.11214521 1.0542925 0.1061333 0.14340000 0.06833333 -0.07506667 1.066697e-02 2.094983e-20 FALSE TRUE
MSTRG.1591.1 ENSG00000097046 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC7 protein_coding   29.72149 10.44708 46.14987 0.7420775 1.445339 2.142159 1.7315669 1.0518869 3.5395835 0.2971720 0.80006985 1.7410196 0.0595250 0.10200000 0.07786667 -0.02413333 8.110829e-01 2.094983e-20 FALSE TRUE
MSTRG.1591.3 ENSG00000097046 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC7 protein_coding   29.72149 10.44708 46.14987 0.7420775 1.445339 2.142159 0.9461693 1.0339687 0.9478418 0.3137370 0.03742773 -0.1242192 0.0403625 0.09756667 0.02053333 -0.07703333 5.809020e-05 2.094983e-20 FALSE TRUE
MSTRG.1591.4 ENSG00000097046 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC7 protein_coding   29.72149 10.44708 46.14987 0.7420775 1.445339 2.142159 0.6325990 0.6629166 0.0000000 0.1277574 0.00000000 -6.0723558 0.0252500 0.06253333 0.00000000 -0.06253333 2.094983e-20 2.094983e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000097046 E001 0.1472490 0.0442254251 1.000000e+00   1 91500719 91500821 103 + 0.057 0.000 -7.607
ENSG00000097046 E002 0.4438354 0.0830579767 8.601471e-02 1.690166e-01 1 91500822 91500823 2 + 0.057 0.395 3.390
ENSG00000097046 E003 10.2470216 0.0366880701 1.255741e-01 2.279654e-01 1 91500824 91500850 27 + 0.883 1.180 1.090
ENSG00000097046 E004 28.9477207 0.0083739337 1.584062e-01 2.730029e-01 1 91500851 91500877 27 + 1.379 1.341 -0.131
ENSG00000097046 E005 90.2760518 0.0003303540 4.028340e-12 8.941499e-11 1 91500878 91500948 71 + 1.892 1.609 -0.956
ENSG00000097046 E006 10.0319096 0.0030726978 2.589517e-01 3.962940e-01 1 91501108 91501137 30 + 0.892 1.113 0.818
ENSG00000097046 E007 11.9347185 0.0014474595 3.324517e-01 4.761049e-01 1 91501138 91501159 22 + 0.964 1.161 0.715
ENSG00000097046 E008 20.4513471 0.0009330766 5.367683e-02 1.156847e-01 1 91501160 91501303 144 + 1.164 1.422 0.906
ENSG00000097046 E009 11.9358816 0.0014348087 5.752233e-01 7.008897e-01 1 91501304 91501482 179 + 1.009 1.031 0.081
ENSG00000097046 E010 108.6757718 0.0004749674 2.019219e-08 2.352613e-07 1 91501654 91501687 34 + 1.959 1.790 -0.570
ENSG00000097046 E011 208.6208519 0.0019573730 3.816771e-08 4.211520e-07 1 91501688 91501831 144 + 2.231 2.114 -0.393
ENSG00000097046 E012 167.5866074 0.0027599344 1.286901e-03 4.933115e-03 1 91507854 91507937 84 + 2.125 2.081 -0.148
ENSG00000097046 E013 214.5726900 0.0002099213 6.066440e-07 5.279626e-06 1 91508262 91508397 136 + 2.234 2.174 -0.202
ENSG00000097046 E014 1.1993242 0.2559774517 2.228924e-01 3.538171e-01 1 91508398 91508405 8 + 0.330 0.000 -10.606
ENSG00000097046 E015 179.9291721 0.0002082329 1.929255e-05 1.201169e-04 1 91511597 91511690 94 + 2.157 2.108 -0.165
ENSG00000097046 E016 169.9008485 0.0002011976 1.244296e-05 8.089781e-05 1 91511781 91511923 143 + 2.134 2.076 -0.193
ENSG00000097046 E017 121.8079981 0.0016167984 3.298445e-02 7.777467e-02 1 91513058 91513126 69 + 1.979 1.980 0.004
ENSG00000097046 E018 227.2484850 0.0028156167 1.730962e-01 2.922036e-01 1 91513127 91513307 181 + 2.240 2.283 0.144
ENSG00000097046 E019 152.6134705 0.0165984081 6.922393e-01 7.935295e-01 1 91513948 91514043 96 + 2.064 2.130 0.221
ENSG00000097046 E020 204.7524604 0.0002796847 2.504849e-01 3.865245e-01 1 91514819 91514997 179 + 2.192 2.253 0.206
ENSG00000097046 E021 153.4503838 0.0016566595 9.094555e-01 9.464862e-01 1 91515794 91515876 83 + 2.062 2.154 0.306
ENSG00000097046 E022 219.8021392 0.0008576663 3.968629e-01 5.406234e-01 1 91520130 91520279 150 + 2.222 2.291 0.232
ENSG00000097046 E023 0.4407149 0.0215388735 5.402641e-01 6.714244e-01 1 91520280 91520280 1 + 0.108 0.242 1.401
ENSG00000097046 E024 1164.6115488 0.0134799830 1.432994e-05 9.181118e-05 1 91524041 91525764 1724 + 2.895 3.161 0.885