ENSG00000097021

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361521 ENSG00000097021 HEK293_OSMI2_2hA HEK293_TMG_2hB ACOT7 protein_coding protein_coding 132.3882 238.039 69.26288 10.3426 1.391539 -1.780896 7.578917 8.01371 0.000000 4.904083 0.000000 -9.648126 0.07514167 0.03206667 0.00000000 -0.03206667 0.273895152 0.009424849 FALSE TRUE
ENST00000377845 ENSG00000097021 HEK293_OSMI2_2hA HEK293_TMG_2hB ACOT7 protein_coding protein_coding 132.3882 238.039 69.26288 10.3426 1.391539 -1.780896 77.585204 147.25528 30.770004 2.568421 2.054905 -2.258352 0.55547083 0.62006667 0.44583333 -0.17423333 0.009424849 0.009424849 FALSE TRUE
ENST00000473466 ENSG00000097021 HEK293_OSMI2_2hA HEK293_TMG_2hB ACOT7 protein_coding protein_coding 132.3882 238.039 69.26288 10.3426 1.391539 -1.780896 1.873058 0.00000 5.438974 0.000000 3.239650 9.089841 0.02608333 0.00000000 0.07713333 0.07713333 0.103049890 0.009424849 FALSE FALSE
ENST00000545482 ENSG00000097021 HEK293_OSMI2_2hA HEK293_TMG_2hB ACOT7 protein_coding protein_coding 132.3882 238.039 69.26288 10.3426 1.391539 -1.780896 5.892423 0.00000 10.543073 0.000000 10.543073 10.043447 0.08894583 0.00000000 0.15853333 0.15853333 0.412360163 0.009424849 FALSE TRUE
ENST00000608083 ENSG00000097021 HEK293_OSMI2_2hA HEK293_TMG_2hB ACOT7 protein_coding protein_coding 132.3882 238.039 69.26288 10.3426 1.391539 -1.780896 39.263378 82.45330 22.371605 3.512882 11.360268 -1.881439 0.25283333 0.34650000 0.31656667 -0.02993333 0.925755602 0.009424849 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000097021 E001 1.5863877 1.673097e-01 5.135515e-01 0.6483623814 1 6264269 6264271 3 - 0.217 0.384 1.133
ENSG00000097021 E002 10.6669900 1.249060e-01 1.635329e-01 0.2797324827 1 6264272 6264272 1 - 0.689 1.005 1.229
ENSG00000097021 E003 117.7191147 5.427863e-03 9.019804e-04 0.0036205159 1 6264273 6264301 29 - 1.787 1.985 0.669
ENSG00000097021 E004 2609.4858429 9.391589e-04 3.862196e-05 0.0002234210 1 6264302 6264695 394 - 3.239 3.306 0.221
ENSG00000097021 E005 1064.8272860 3.684820e-04 2.258509e-02 0.0568889910 1 6281102 6281129 28 - 2.873 2.912 0.130
ENSG00000097021 E006 1844.2189111 9.970741e-05 1.569932e-01 0.2710980617 1 6281130 6281252 123 - 3.129 3.145 0.055
ENSG00000097021 E007 966.1914377 1.321554e-04 6.850381e-02 0.1408980905 1 6281253 6281286 34 - 2.883 2.857 -0.087
ENSG00000097021 E008 2.5764570 1.090859e-02 3.024229e-01 0.4442945188 1 6282724 6282796 73 - 0.627 0.446 -0.850
ENSG00000097021 E009 1.8025223 2.179163e-02 8.777486e-01 0.9254764872 1 6282797 6282888 92 - 0.361 0.392 0.181
ENSG00000097021 E010 1477.7526176 9.914388e-05 6.534576e-01 0.7639333065 1 6294864 6294980 117 - 3.050 3.045 -0.014
ENSG00000097021 E011 2.6802920 5.692149e-01 7.350680e-01 0.8259101147 1 6294981 6295504 524 - 0.693 0.428 -1.228
ENSG00000097021 E012 1285.3388508 1.192581e-04 4.439845e-01 0.5855718145 1 6318492 6318578 87 - 2.994 2.985 -0.029
ENSG00000097021 E013 1481.2561416 8.175998e-04 9.040557e-01 0.9429436766 1 6327299 6327413 115 - 3.049 3.049 0.001
ENSG00000097021 E014 1340.1659500 6.201843e-04 1.159975e-01 0.2142370996 1 6333477 6333568 92 - 3.025 3.002 -0.078
ENSG00000097021 E015 1095.6063056 4.672209e-04 2.130593e-01 0.3421526285 1 6339433 6339525 93 - 2.933 2.914 -0.061
ENSG00000097021 E016 928.7276407 8.331669e-04 5.718998e-01 0.6981063014 1 6339526 6339589 64 - 2.853 2.844 -0.029
ENSG00000097021 E017 1045.2610425 1.538887e-03 3.533363e-02 0.0822926686 1 6349749 6349866 118 - 2.933 2.889 -0.147
ENSG00000097021 E018 0.1472490 4.301889e-02 1.094117e-01   1 6352225 6352249 25 - 0.217 0.000 -11.388
ENSG00000097021 E019 0.3299976 2.744240e-02 1.000000e+00   1 6358826 6359344 519 - 0.000 0.123 9.642
ENSG00000097021 E020 0.0000000       1 6360570 6360707 138 -      
ENSG00000097021 E021 0.0000000       1 6385494 6385813 320 -      
ENSG00000097021 E022 674.5787734 2.274238e-03 1.400891e-04 0.0007039456 1 6393257 6393767 511 - 2.791 2.687 -0.344