ENSG00000097007

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318560 ENSG00000097007 HEK293_OSMI2_2hA HEK293_TMG_2hB ABL1 protein_coding protein_coding 19.28307 24.13549 14.90247 2.42724 0.8848598 -0.6952348 7.279014 11.0394453 4.850496 1.2264186 0.4646202 -1.18479847 0.3669500 0.46213333 0.32850000 -0.1336333 0.251965279 0.002019689 FALSE TRUE
ENST00000372348 ENSG00000097007 HEK293_OSMI2_2hA HEK293_TMG_2hB ABL1 protein_coding protein_coding 19.28307 24.13549 14.90247 2.42724 0.8848598 -0.6952348 8.264831 7.8089599 7.928658 1.3525622 0.1806659 0.02191844 0.4411375 0.31916667 0.53650000 0.2173333 0.002019689 0.002019689 FALSE TRUE
ENST00000674075 ENSG00000097007 HEK293_OSMI2_2hA HEK293_TMG_2hB ABL1 protein_coding protein_coding 19.28307 24.13549 14.90247 2.42724 0.8848598 -0.6952348 0.996672 0.8092715 1.004533 0.8092715 1.0045326 0.30840172 0.0534875 0.02886667 0.06026667 0.0314000 0.995942761 0.002019689   FALSE
MSTRG.33527.3 ENSG00000097007 HEK293_OSMI2_2hA HEK293_TMG_2hB ABL1 protein_coding   19.28307 24.13549 14.90247 2.42724 0.8848598 -0.6952348 2.742552 4.4778103 1.118779 0.2927939 0.2964830 -1.99124898 0.1384333 0.18980000 0.07476667 -0.1150333 0.034868015 0.002019689 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000097007 E001 100.84824 0.0061460547 2.416080e-05 1.470820e-04 9 130713016 130713625 610 + 2.057 1.947 -0.367
ENSG00000097007 E002 139.14126 0.0014232883 1.196857e-09 1.747388e-08 9 130713626 130713979 354 + 2.194 2.089 -0.350
ENSG00000097007 E003 165.77401 0.0047288803 1.759613e-04 8.609331e-04 9 130713980 130714455 476 + 2.240 2.188 -0.173
ENSG00000097007 E004 23.34634 0.0384398809 4.631772e-02 1.026083e-01 9 130835254 130835525 272 + 1.446 1.312 -0.464
ENSG00000097007 E005 40.87154 0.0159667269 5.706644e-02 1.215806e-01 9 130854064 130854066 3 + 1.632 1.588 -0.151
ENSG00000097007 E006 119.90208 0.0094157543 6.264483e-03 1.930615e-02 9 130854067 130854237 171 + 2.093 2.051 -0.142
ENSG00000097007 E007 188.79677 0.0081292457 2.278055e-02 5.729069e-02 9 130854801 130855096 296 + 2.265 2.264 -0.002
ENSG00000097007 E008 196.50104 0.0002777404 2.192588e-08 2.537907e-07 9 130862763 130863035 273 + 2.306 2.264 -0.141
ENSG00000097007 E009 114.31041 0.0002498127 1.283787e-03 4.922772e-03 9 130872129 130872213 85 + 2.051 2.045 -0.020
ENSG00000097007 E010 182.28492 0.0039920195 1.111040e-03 4.340306e-03 9 130872860 130873037 178 + 2.266 2.241 -0.083
ENSG00000097007 E011 198.89752 0.0017710604 1.798707e-04 8.774709e-04 9 130874868 130875052 185 + 2.297 2.282 -0.049
ENSG00000097007 E012 159.00814 0.0023979117 9.290370e-03 2.701094e-02 9 130878415 130878567 153 + 2.183 2.194 0.038
ENSG00000097007 E013 131.31491 0.0039643910 1.337537e-02 3.679232e-02 9 130880068 130880157 90 + 2.109 2.109 0.000
ENSG00000097007 E014 161.58471 0.0057609783 2.726783e-02 6.653541e-02 9 130880500 130880664 165 + 2.192 2.202 0.034
ENSG00000097007 E015 2173.94789 0.0055613921 3.169428e-12 7.169416e-11 9 130883969 130887675 3707 + 3.161 3.404 0.807