ENSG00000096872

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380062 ENSG00000096872 HEK293_OSMI2_2hA HEK293_TMG_2hB IFT74 protein_coding protein_coding 8.431578 2.141171 14.07812 0.405138 0.8669109 2.711285 1.5621348 0.5991323 2.46935727 0.09787845 0.11915315 2.025139 0.22611250 0.28326667 0.1757667 -0.10750000 3.761058e-02 9.147745e-05 FALSE TRUE
ENST00000429045 ENSG00000096872 HEK293_OSMI2_2hA HEK293_TMG_2hB IFT74 protein_coding protein_coding 8.431578 2.141171 14.07812 0.405138 0.8669109 2.711285 3.4661053 0.6663838 6.20540665 0.08652902 0.40255123 3.199935 0.39087917 0.32096667 0.4407667 0.11980000 7.492107e-02 9.147745e-05 FALSE TRUE
ENST00000482986 ENSG00000096872 HEK293_OSMI2_2hA HEK293_TMG_2hB IFT74 protein_coding retained_intron 8.431578 2.141171 14.07812 0.405138 0.8669109 2.711285 2.1758130 0.5812025 3.61944809 0.34257418 0.40025779 2.618026 0.23526250 0.22486667 0.2555667 0.03070000 8.339092e-01 9.147745e-05 FALSE FALSE
ENST00000494236 ENSG00000096872 HEK293_OSMI2_2hA HEK293_TMG_2hB IFT74 protein_coding retained_intron 8.431578 2.141171 14.07812 0.405138 0.8669109 2.711285 0.1324762 0.1370438 0.06205398 0.07268047 0.03103001 -1.029096 0.04149583 0.08396667 0.0044000 -0.07956667 1.975422e-01 9.147745e-05   FALSE
ENST00000518614 ENSG00000096872 HEK293_OSMI2_2hA HEK293_TMG_2hB IFT74 protein_coding protein_coding 8.431578 2.141171 14.07812 0.405138 0.8669109 2.711285 0.7070121 0.0000000 1.27473110 0.00000000 0.15469817 7.005323 0.05725000 0.00000000 0.0925000 0.09250000 9.147745e-05 9.147745e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000096872 E001 0.1451727 0.0423678019 1.000000e+00   9 26947039 26947146 108 + 0.060 0.000 -8.539
ENSG00000096872 E002 1.4341202 0.0097429315 7.153439e-01 0.8112766812 9 26947300 26947311 12 + 0.311 0.384 0.443
ENSG00000096872 E003 2.3187723 0.0065959159 7.980179e-01 0.8711103967 9 26947312 26947463 152 + 0.446 0.495 0.249
ENSG00000096872 E004 1.2608349 0.0108647759 7.076147e-01 0.8054767226 9 26956350 26956411 62 + 0.311 0.233 -0.557
ENSG00000096872 E005 15.4752504 0.0017083650 1.790044e-03 0.0065675793 9 26956412 26956478 67 + 1.181 0.776 -1.513
ENSG00000096872 E006 19.3577747 0.0029473793 5.277699e-03 0.0166877103 9 26956479 26956516 38 + 1.263 0.945 -1.148
ENSG00000096872 E007 38.0660943 0.0006080723 9.804223e-03 0.0282792421 9 26961949 26962087 139 + 1.531 1.334 -0.681
ENSG00000096872 E008 0.0000000       9 26976567 26976782 216 +      
ENSG00000096872 E009 42.8862096 0.0005314159 3.381351e-02 0.0793837081 9 26978128 26978263 136 + 1.573 1.424 -0.511
ENSG00000096872 E010 31.0297079 0.0006816451 4.666526e-02 0.1032313932 9 26980571 26980619 49 + 1.438 1.273 -0.574
ENSG00000096872 E011 0.1451727 0.0423678019 1.000000e+00   9 26982286 26982399 114 + 0.060 0.000 -8.534
ENSG00000096872 E012 0.1451727 0.0423678019 1.000000e+00   9 26983832 26984256 425 + 0.060 0.000 -8.534
ENSG00000096872 E013 39.8002255 0.0005286185 7.082230e-03 0.0214409167 9 26984257 26984355 99 + 1.550 1.348 -0.696
ENSG00000096872 E014 36.3044206 0.0006733123 4.017778e-03 0.0131916121 9 26984499 26984559 61 + 1.518 1.289 -0.792
ENSG00000096872 E015 35.1191542 0.0005972691 1.860987e-03 0.0067923094 9 26988669 26988728 60 + 1.510 1.256 -0.881
ENSG00000096872 E016 42.3145086 0.0172072807 1.287209e-01 0.2323739515 9 26990134 26990195 62 + 1.571 1.433 -0.474
ENSG00000096872 E017 1.0027668 0.0166053790 8.525246e-03 0.0251003536 9 26992383 26992677 295 + 0.113 0.584 3.248
ENSG00000096872 E018 62.2731626 0.0004639459 2.069329e-01 0.3348750415 9 27009020 27009158 139 + 1.723 1.653 -0.236
ENSG00000096872 E019 43.0861261 0.0005444339 9.561258e-01 0.9765278182 9 27011906 27011968 63 + 1.548 1.554 0.019
ENSG00000096872 E020 56.0015278 0.0008859225 7.933698e-01 0.8678852149 9 27016907 27017050 144 + 1.656 1.673 0.058
ENSG00000096872 E021 32.7475189 0.0007404337 5.417759e-01 0.6727052134 9 27018647 27018687 41 + 1.421 1.468 0.162
ENSG00000096872 E022 0.0000000       9 27028808 27029024 217 +      
ENSG00000096872 E023 43.3814063 0.0005379430 6.495652e-01 0.7608206198 9 27029025 27029104 80 + 1.555 1.527 -0.097
ENSG00000096872 E024 4.8508357 0.0038698825 4.720386e-01 0.6111172861 9 27036450 27036800 351 + 0.661 0.776 0.471
ENSG00000096872 E025 39.0957444 0.0006073818 7.226865e-01 0.8167585439 9 27044742 27044795 54 + 1.512 1.489 -0.079
ENSG00000096872 E026 50.2929858 0.0004645987 6.243703e-01 0.7406916052 9 27047274 27047371 98 + 1.608 1.639 0.106
ENSG00000096872 E027 54.6047134 0.0004475223 5.490168e-02 0.1178258531 9 27048148 27048274 127 + 1.625 1.734 0.370
ENSG00000096872 E028 55.4480368 0.0004095058 1.277017e-02 0.0353741022 9 27055609 27055772 164 + 1.624 1.762 0.468
ENSG00000096872 E029 55.4718154 0.0004188806 1.907031e-04 0.0009242060 9 27056334 27056459 126 + 1.606 1.807 0.681
ENSG00000096872 E030 38.6362492 0.0005357085 3.478393e-04 0.0015715605 9 27060591 27060651 61 + 1.445 1.673 0.780
ENSG00000096872 E031 65.3682439 0.0044657566 2.536738e-05 0.0001535784 9 27062618 27066134 3517 + 1.669 1.906 0.798