ENSG00000096746

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265866 ENSG00000096746 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPH3 protein_coding protein_coding 188.7536 92.73532 319.0561 1.545282 11.15431 1.782509 52.09169 34.38973 86.49112 0.9619317 0.9067917 1.330322 0.2875875 0.37073333 0.27166667 -0.09906667 6.300194e-07 6.300194e-07 FALSE  
ENST00000354695 ENSG00000096746 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPH3 protein_coding protein_coding 188.7536 92.73532 319.0561 1.545282 11.15431 1.782509 20.87148 14.15629 28.92339 2.6382307 2.8090802 1.030273 0.1208167 0.15276667 0.09026667 -0.06250000 1.526829e-01 6.300194e-07 FALSE  
ENST00000467249 ENSG00000096746 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPH3 protein_coding processed_transcript 188.7536 92.73532 319.0561 1.545282 11.15431 1.782509 41.08994 18.18957 66.61426 2.6847939 2.5852899 1.872144 0.2109500 0.19663333 0.20896667 0.01233333 8.817550e-01 6.300194e-07 FALSE  
ENST00000480987 ENSG00000096746 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPH3 protein_coding processed_transcript 188.7536 92.73532 319.0561 1.545282 11.15431 1.782509 38.29750 20.38434 65.05751 1.2674202 3.8008013 1.673769 0.2101792 0.21976667 0.20360000 -0.01616667 7.309607e-01 6.300194e-07    
ENST00000486854 ENSG00000096746 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPH3 protein_coding processed_transcript 188.7536 92.73532 319.0561 1.545282 11.15431 1.782509 26.74150 2.28270 57.09330 1.1980802 1.9274344 4.638455 0.1141583 0.02426667 0.17896667 0.15470000 1.963762e-01 6.300194e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000096746 E001 0.1451727 4.330538e-02 1.000000e+00   10 68331174 68331244 71 + 0.080 0.000 -8.319
ENSG00000096746 E002 0.2903454 3.324323e-01 7.060160e-01   10 68331245 68331251 7 + 0.147 0.000 -9.297
ENSG00000096746 E003 1.6449709 1.819782e-01 6.134068e-01 7.320765e-01 10 68331252 68331720 469 + 0.449 0.309 -0.805
ENSG00000096746 E004 5.0771110 8.757994e-03 4.921934e-01 6.293862e-01 10 68331721 68331854 134 + 0.720 0.830 0.438
ENSG00000096746 E005 21.8437992 2.374425e-03 9.746951e-01 9.882158e-01 10 68331855 68332063 209 + 1.323 1.341 0.062
ENSG00000096746 E006 42.7304289 1.261532e-02 2.866375e-01 4.270618e-01 10 68332064 68332075 12 + 1.630 1.564 -0.227
ENSG00000096746 E007 346.9791563 1.470731e-03 2.149488e-07 2.047845e-06 10 68332076 68332102 27 + 2.549 2.414 -0.448
ENSG00000096746 E008 415.2944167 1.313471e-03 1.761999e-07 1.706833e-06 10 68332103 68332116 14 + 2.624 2.500 -0.413
ENSG00000096746 E009 433.2023412 1.295277e-03 1.289249e-07 1.281988e-06 10 68332117 68332121 5 + 2.642 2.519 -0.411
ENSG00000096746 E010 795.2906512 6.812312e-04 6.769328e-15 2.290870e-13 10 68332122 68332216 95 + 2.908 2.776 -0.441
ENSG00000096746 E011 247.9736253 1.949837e-03 6.648773e-04 2.770217e-03 10 68332217 68332235 19 + 2.395 2.293 -0.337
ENSG00000096746 E012 30.8073438 1.685570e-02 9.646598e-04 3.837633e-03 10 68336806 68337198 393 + 1.547 1.227 -1.112
ENSG00000096746 E013 1276.8713513 6.737270e-04 1.158061e-16 4.937906e-15 10 68337199 68337333 135 + 3.111 2.990 -0.402
ENSG00000096746 E014 30.9989651 6.573243e-04 1.202385e-01 2.203313e-01 10 68337334 68337615 282 + 1.502 1.408 -0.323
ENSG00000096746 E015 55.8215215 4.905854e-03 3.083091e-09 4.172315e-08 10 68337616 68337857 242 + 1.816 1.417 -1.358
ENSG00000096746 E016 1370.0168932 1.111644e-04 1.087510e-14 3.557070e-13 10 68337858 68337996 139 + 3.129 3.057 -0.239
ENSG00000096746 E017 28.1074840 1.338530e-02 1.143387e-01 2.118737e-01 10 68337997 68338339 343 + 1.471 1.341 -0.449
ENSG00000096746 E018 21.9186341 6.851418e-03 2.155276e-01 3.450493e-01 10 68338340 68338502 163 + 1.359 1.261 -0.342
ENSG00000096746 E019 1367.2345721 8.289757e-05 8.147036e-02 1.618599e-01 10 68338503 68338642 140 + 3.107 3.103 -0.013
ENSG00000096746 E020 491.3787362 6.504400e-04 4.676603e-01 6.071604e-01 10 68338643 68338687 45 + 2.662 2.660 -0.004
ENSG00000096746 E021 36.1475475 6.427921e-03 8.500566e-05 4.516890e-04 10 68338806 68339139 334 + 1.614 1.310 -1.048
ENSG00000096746 E022 1277.9781234 6.914988e-04 1.888482e-02 4.908115e-02 10 68339140 68339226 87 + 3.060 3.110 0.166
ENSG00000096746 E023 1266.9382439 1.965705e-04 4.846415e-14 1.441122e-12 10 68339440 68339555 116 + 3.037 3.141 0.345
ENSG00000096746 E024 1248.2195618 1.023187e-04 7.793313e-20 4.851856e-18 10 68341174 68341309 136 + 3.026 3.142 0.383
ENSG00000096746 E025 33.8507167 7.929980e-03 1.652370e-02 4.389305e-02 10 68341310 68341584 275 + 1.562 1.380 -0.624
ENSG00000096746 E026 1089.6817368 8.780397e-04 2.188529e-06 1.687259e-05 10 68341585 68341680 96 + 2.974 3.073 0.329
ENSG00000096746 E027 25.1541259 1.124396e-03 2.965460e-01 4.377825e-01 10 68341681 68341758 78 + 1.359 1.450 0.315
ENSG00000096746 E028 1062.9513117 5.101849e-03 2.949087e-02 7.094819e-02 10 68341759 68341851 93 + 2.963 3.061 0.324
ENSG00000096746 E029 13.5725358 3.795530e-02 8.170671e-01 8.843022e-01 10 68341852 68341977 126 + 1.124 1.163 0.139
ENSG00000096746 E030 1983.5917593 2.227318e-03 2.300293e-04 1.091861e-03 10 68341978 68343193 1216 + 3.234 3.331 0.323