ENSG00000096696

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379802 ENSG00000096696 HEK293_OSMI2_2hA HEK293_TMG_2hB DSP protein_coding protein_coding 18.77943 18.25974 21.7963 2.259032 0.1593857 0.2552889 11.296514 9.151153 15.038576 1.7646405 0.1253657 0.7160259 0.5978958 0.4930000 0.6901 0.1971000 0.000522638 0.000522638 FALSE TRUE
ENST00000418664 ENSG00000096696 HEK293_OSMI2_2hA HEK293_TMG_2hB DSP protein_coding protein_coding 18.77943 18.25974 21.7963 2.259032 0.1593857 0.2552889 6.847953 8.072950 6.168518 0.5045988 0.3903689 -0.3876210 0.3677125 0.4490667 0.2828 -0.1662667 0.002537377 0.000522638 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000096696 E001 0.8878743 0.0131199444 2.010543e-02 5.170729e-02 6 7540220 7541454 1235 + 0.362 0.000 -21.338
ENSG00000096696 E002 10.6147291 0.1328281628 4.509868e-02 1.003784e-01 6 7541608 7541616 9 + 1.090 0.948 -0.520
ENSG00000096696 E003 19.6380038 0.0929323160 2.447462e-02 6.080125e-02 6 7541617 7541670 54 + 1.326 1.227 -0.347
ENSG00000096696 E004 91.7897391 0.0070529001 1.111688e-09 1.634251e-08 6 7541671 7542020 350 + 1.983 1.865 -0.397
ENSG00000096696 E005 29.9274741 0.0007506606 1.840758e-07 1.776405e-06 6 7542021 7542023 3 + 1.516 1.380 -0.470
ENSG00000096696 E006 54.5356451 0.0004339839 1.093060e-10 1.916314e-09 6 7542024 7542085 62 + 1.760 1.653 -0.361
ENSG00000096696 E007 71.9557131 0.0025567317 2.260834e-12 5.236042e-11 6 7555718 7555820 103 + 1.884 1.751 -0.450
ENSG00000096696 E008 5.3754880 0.0121576546 6.452785e-06 4.479355e-05 6 7555821 7556109 289 + 0.319 1.137 3.553
ENSG00000096696 E009 79.4300428 0.0057693013 5.684726e-11 1.045282e-09 6 7558116 7558264 149 + 1.930 1.784 -0.491
ENSG00000096696 E010 54.3207685 0.0226006269 1.482205e-04 7.393153e-04 6 7559226 7559285 60 + 1.753 1.657 -0.326
ENSG00000096696 E011 74.0976456 0.0177038199 1.761708e-04 8.618693e-04 6 7559286 7559400 115 + 1.872 1.820 -0.175
ENSG00000096696 E012 0.2966881 0.0290785164 2.984084e-01   6 7559401 7560821 1421 + 0.156 0.000 -19.753
ENSG00000096696 E013 101.5371142 0.0003605905 2.425990e-19 1.440290e-17 6 7562652 7562780 129 + 2.026 1.907 -0.400
ENSG00000096696 E014 73.3443570 0.0009942032 2.816334e-10 4.603504e-09 6 7563736 7563786 51 + 1.872 1.807 -0.217
ENSG00000096696 E015 0.0000000       6 7565258 7565358 101 +      
ENSG00000096696 E016 112.1564062 0.0026972653 7.960389e-15 2.658801e-13 6 7565359 7565520 162 + 2.068 1.954 -0.382
ENSG00000096696 E017 0.3697384 0.0256795621 1.290617e-01 2.328716e-01 6 7565521 7565817 297 + 0.000 0.296 21.829
ENSG00000096696 E018 90.7628887 0.0153706740 2.934162e-07 2.721109e-06 6 7566377 7566481 105 + 1.984 1.848 -0.457
ENSG00000096696 E019 81.3076880 0.0030115423 1.347054e-12 3.232776e-11 6 7567354 7567449 96 + 1.935 1.805 -0.439
ENSG00000096696 E020 0.0000000       6 7567450 7567780 331 +      
ENSG00000096696 E021 81.9592350 0.0032516329 5.074964e-14 1.505774e-12 6 7567781 7567906 126 + 1.947 1.787 -0.536
ENSG00000096696 E022 0.0000000       6 7567907 7568436 530 +      
ENSG00000096696 E023 104.1017611 0.0002564484 6.148434e-27 7.886273e-25 6 7568437 7568589 153 + 2.055 1.871 -0.618
ENSG00000096696 E024 106.1176139 0.0035849352 4.769915e-16 1.878292e-14 6 7569186 7569340 155 + 2.056 1.896 -0.540
ENSG00000096696 E025 52.3405889 0.0080981309 1.023069e-06 8.466971e-06 6 7570437 7570478 42 + 1.738 1.627 -0.377
ENSG00000096696 E026 78.9260439 0.0010639233 2.180821e-17 1.017611e-15 6 7570479 7570563 85 + 1.931 1.769 -0.545
ENSG00000096696 E027 143.1132792 0.0002784768 1.236237e-34 2.957089e-32 6 7571383 7571584 202 + 2.189 2.012 -0.593
ENSG00000096696 E028 1.1824861 0.0122020794 6.045282e-03 1.873055e-02 6 7571585 7571841 257 + 0.437 0.000 -21.753
ENSG00000096696 E029 141.9218125 0.0110325020 3.818464e-07 3.456432e-06 6 7571842 7572068 227 + 2.157 2.081 -0.254
ENSG00000096696 E030 111.1355690 0.0064451447 5.506295e-04 2.349122e-03 6 7574086 7574252 167 + 2.009 2.059 0.168
ENSG00000096696 E031 128.2266575 0.0002690623 2.996012e-06 2.241826e-05 6 7574657 7574795 139 + 2.062 2.132 0.235
ENSG00000096696 E032 171.3519404 0.0002193399 7.462825e-11 1.343798e-09 6 7575295 7575488 194 + 2.199 2.237 0.128
ENSG00000096696 E033 0.0000000       6 7575489 7575851 363 +      
ENSG00000096696 E034 134.5877721 0.0037918659 2.338940e-04 1.107947e-03 6 7576294 7576456 163 + 2.085 2.153 0.228
ENSG00000096696 E035 96.0921152 0.0004876718 1.869814e-05 1.167768e-04 6 7576959 7577042 84 + 1.943 2.002 0.198
ENSG00000096696 E036 94.8787263 0.0064446059 6.958966e-02 1.426732e-01 6 7577779 7577886 108 + 1.909 2.039 0.437
ENSG00000096696 E037 98.9638306 0.0065177900 6.426354e-01 7.553928e-01 6 7578464 7578562 99 + 1.896 2.095 0.670
ENSG00000096696 E038 336.7194946 0.0047133938 1.805947e-03 6.617883e-03 6 7579275 7579772 498 + 2.464 2.576 0.371
ENSG00000096696 E039 639.6451599 0.0018205322 3.915238e-03 1.290549e-02 6 7579773 7581569 1797 + 2.721 2.882 0.533
ENSG00000096696 E040 2760.7696935 0.0134002425 4.159940e-17 1.871543e-15 6 7582642 7586714 4073 + 3.181 3.674 1.638