ENSG00000096070

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357641 ENSG00000096070 HEK293_OSMI2_2hA HEK293_TMG_2hB BRPF3 protein_coding protein_coding 16.84519 20.39512 16.28678 1.897856 0.216828 -0.3243445 9.0499746 7.4159257 11.8768324 1.3042443 0.3446027 0.6787215 0.54900000 0.3601667 0.72963333 0.36946667 8.199959e-07 8.199959e-07 FALSE TRUE
ENST00000441123 ENSG00000096070 HEK293_OSMI2_2hA HEK293_TMG_2hB BRPF3 protein_coding nonsense_mediated_decay 16.84519 20.39512 16.28678 1.897856 0.216828 -0.3243445 1.0498842 0.9759784 1.3898819 0.2479779 0.2863538 0.5056771 0.06337500 0.0463000 0.08580000 0.03950000 2.949326e-01 8.199959e-07 TRUE TRUE
ENST00000441730 ENSG00000096070 HEK293_OSMI2_2hA HEK293_TMG_2hB BRPF3 protein_coding nonsense_mediated_decay 16.84519 20.39512 16.28678 1.897856 0.216828 -0.3243445 3.9761611 8.4896072 1.3447790 0.8075976 0.3305559 -2.6493387 0.22267500 0.4211000 0.08230000 -0.33880000 1.885511e-06 8.199959e-07 TRUE TRUE
ENST00000534400 ENSG00000096070 HEK293_OSMI2_2hA HEK293_TMG_2hB BRPF3 protein_coding protein_coding 16.84519 20.39512 16.28678 1.897856 0.216828 -0.3243445 0.9478185 1.3845889 0.6627371 0.2646611 0.3339546 -1.0517251 0.05764167 0.0683000 0.04036667 -0.02793333 6.853153e-01 8.199959e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000096070 E001 7.0567944 0.0023422789 1.931918e-11 3.838449e-10 6 36196744 36196819 76 + 1.174 0.302 -3.798
ENSG00000096070 E002 21.6655004 0.0304075055 1.129753e-03 4.403693e-03 6 36196820 36196965 146 + 1.483 1.185 -1.041
ENSG00000096070 E003 13.8430635 0.0499519351 3.876006e-01 5.317414e-01 6 36196966 36196970 5 + 1.191 1.137 -0.194
ENSG00000096070 E004 0.9599941 0.0583362859 8.828071e-02 1.724973e-01 6 36197396 36197451 56 + 0.412 0.126 -2.239
ENSG00000096070 E005 0.6633060 0.0231363788 2.778556e-01 4.174875e-01 6 36197452 36197497 46 + 0.290 0.125 -1.506
ENSG00000096070 E006 0.8115992 0.0158310259 5.932638e-01 7.156906e-01 6 36197498 36197620 123 + 0.290 0.222 -0.508
ENSG00000096070 E007 44.4804904 0.0215545103 1.662312e-02 4.410643e-02 6 36200297 36200405 109 + 1.726 1.582 -0.490
ENSG00000096070 E008 128.4801528 0.0037134247 1.629795e-06 1.292422e-05 6 36200406 36200682 277 + 2.175 2.036 -0.464
ENSG00000096070 E009 60.7521482 0.0039801930 4.393121e-04 1.925778e-03 6 36200683 36200709 27 + 1.846 1.718 -0.432
ENSG00000096070 E010 99.4777315 0.0022387007 2.522866e-08 2.883730e-07 6 36200710 36200817 108 + 2.077 1.907 -0.573
ENSG00000096070 E011 382.9677699 0.0011203057 8.783399e-15 2.914676e-13 6 36200818 36201770 953 + 2.636 2.524 -0.375
ENSG00000096070 E012 1.9898148 0.0387655976 8.823232e-01 9.286563e-01 6 36204414 36204657 244 + 0.412 0.481 0.356
ENSG00000096070 E013 98.9335538 0.0033663320 1.238039e-01 2.253832e-01 6 36204658 36204814 157 + 2.001 1.994 -0.023
ENSG00000096070 E014 109.0322235 0.0042779857 9.226362e-02 1.786659e-01 6 36207313 36207444 132 + 2.046 2.032 -0.049
ENSG00000096070 E015 95.9427182 0.0051567704 2.079129e-01 3.359817e-01 6 36209787 36209915 129 + 1.985 1.985 -0.002
ENSG00000096070 E016 4.1579385 0.0038751300 7.001406e-01 7.996644e-01 6 36210201 36210215 15 + 0.652 0.754 0.425
ENSG00000096070 E017 148.4427743 0.0013750615 7.708216e-02 1.548165e-01 6 36210216 36210528 313 + 2.167 2.169 0.007
ENSG00000096070 E018 4.2382634 0.0041706202 3.405115e-01 4.844574e-01 6 36211201 36211257 57 + 0.620 0.802 0.754
ENSG00000096070 E019 125.9695036 0.0002956438 1.895785e-01 3.132257e-01 6 36211258 36211447 190 + 2.088 2.105 0.059
ENSG00000096070 E020 103.3204161 0.0002807204 4.043061e-01 5.480161e-01 6 36211448 36211560 113 + 1.997 2.027 0.101
ENSG00000096070 E021 2.3155460 0.0068458581 4.983264e-01 6.348036e-01 6 36213860 36213879 20 + 0.412 0.566 0.758
ENSG00000096070 E022 263.8952142 0.0001656685 1.018779e-02 2.922719e-02 6 36213880 36214386 507 + 2.415 2.419 0.013
ENSG00000096070 E023 118.2107815 0.0002734290 3.791625e-01 5.234404e-01 6 36217917 36218010 94 + 2.054 2.084 0.102
ENSG00000096070 E024 115.1600584 0.0003059486 3.844911e-01 5.286356e-01 6 36222168 36222265 98 + 2.009 2.097 0.296
ENSG00000096070 E025 55.6715108 0.0188649434 8.239461e-01 8.890769e-01 6 36225267 36225270 4 + 1.698 1.784 0.289
ENSG00000096070 E026 117.9056230 0.0142835914 9.084230e-01 9.458535e-01 6 36225271 36225364 94 + 2.038 2.096 0.195
ENSG00000096070 E027 147.9543894 0.0042065566 7.373504e-01 8.275628e-01 6 36228902 36229056 155 + 2.123 2.201 0.260
ENSG00000096070 E028 1247.2801254 0.0046751104 7.385631e-13 1.850775e-11 6 36230426 36232790 2365 + 2.952 3.190 0.791