ENSG00000095906

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000262302 ENSG00000095906 HEK293_OSMI2_2hA HEK293_TMG_2hB NUBP2 protein_coding protein_coding 157.3619 300.8516 78.91229 15.78956 3.509602 -1.930595 68.850907 140.59158 27.528486 7.762465 1.8459975 -2.352092 0.4081042 0.4672 0.3485333 -0.11866667 2.450889e-05 1.683291e-16 FALSE TRUE
ENST00000565134 ENSG00000095906 HEK293_OSMI2_2hA HEK293_TMG_2hB NUBP2 protein_coding protein_coding 157.3619 300.8516 78.91229 15.78956 3.509602 -1.930595 7.388725 11.59870 3.625092 1.433440 0.2118869 -1.675143 0.0537250 0.0383 0.0459000 0.00760000 4.166648e-01 1.683291e-16 FALSE TRUE
ENST00000568834 ENSG00000095906 HEK293_OSMI2_2hA HEK293_TMG_2hB NUBP2 protein_coding nonsense_mediated_decay 157.3619 300.8516 78.91229 15.78956 3.509602 -1.930595 49.121880 99.57179 27.213459 3.002109 2.0102628 -1.871032 0.3044083 0.3318 0.3439667 0.01216667 8.091205e-01 1.683291e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000095906 E001 24.56276 3.108165e-02 6.589408e-02 1.365310e-01 16 1782673 1782893 221 + 1.438 1.237 -0.700
ENSG00000095906 E002 19.12133 9.827419e-03 9.503300e-01 9.729131e-01 16 1782894 1782911 18 + 1.153 1.173 0.072
ENSG00000095906 E003 20.55168 1.386679e-02 7.926516e-01 8.674319e-01 16 1782912 1782931 20 + 1.210 1.198 -0.043
ENSG00000095906 E004 18.02423 1.017992e-02 3.978442e-01 5.415941e-01 16 1782932 1782938 7 + 1.210 1.133 -0.274
ENSG00000095906 E005 54.16650 9.010460e-03 6.304208e-01 7.455977e-01 16 1782939 1782955 17 + 1.624 1.605 -0.064
ENSG00000095906 E006 58.55436 1.127345e-02 3.855361e-01 5.297300e-01 16 1782956 1782959 4 + 1.681 1.634 -0.161
ENSG00000095906 E007 91.05366 4.680845e-03 1.658250e-01 2.827739e-01 16 1782960 1782967 8 + 1.883 1.820 -0.213
ENSG00000095906 E008 216.17546 2.684278e-03 6.047054e-01 7.251481e-01 16 1782968 1782989 22 + 2.209 2.204 -0.017
ENSG00000095906 E009 238.45283 3.298106e-03 6.442411e-01 7.565867e-01 16 1782990 1782994 5 + 2.250 2.247 -0.008
ENSG00000095906 E010 238.26791 3.194277e-03 6.717159e-01 7.778824e-01 16 1782995 1782995 1 + 2.248 2.247 -0.003
ENSG00000095906 E011 255.16315 3.598180e-03 4.469717e-01 5.884015e-01 16 1782996 1782998 3 + 2.290 2.275 -0.049
ENSG00000095906 E012 348.12844 1.604047e-03 8.165443e-02 1.621423e-01 16 1782999 1783006 8 + 2.443 2.405 -0.129
ENSG00000095906 E013 482.65249 2.851556e-03 1.866924e-01 3.095831e-01 16 1783007 1783022 16 + 2.578 2.550 -0.092
ENSG00000095906 E014 596.24875 1.645751e-03 3.206724e-01 4.638286e-01 16 1783023 1783036 14 + 2.655 2.644 -0.036
ENSG00000095906 E015 46.62892 5.377728e-04 1.053980e-23 1.011516e-21 16 1783037 1783506 470 + 1.933 1.398 -1.819
ENSG00000095906 E016 13.58941 8.482155e-03 1.972458e-05 1.225168e-04 16 1783853 1783876 24 + 1.359 0.925 -1.560
ENSG00000095906 E017 40.86165 4.828700e-03 3.879070e-06 2.830587e-05 16 1783877 1784009 133 + 1.727 1.420 -1.047
ENSG00000095906 E018 42.40452 5.332770e-04 1.115073e-08 1.362581e-07 16 1784010 1784066 57 + 1.763 1.430 -1.134
ENSG00000095906 E019 24.71858 6.891624e-03 4.383559e-08 4.781782e-07 16 1784067 1784116 50 + 1.610 1.171 -1.524
ENSG00000095906 E020 89.58593 5.562499e-03 1.556420e-11 3.140139e-10 16 1784117 1784369 253 + 2.096 1.745 -1.184
ENSG00000095906 E021 24.33246 1.161200e-03 9.180970e-12 1.925077e-10 16 1784460 1784611 152 + 1.644 1.150 -1.714
ENSG00000095906 E022 11.07027 1.149167e-02 1.707051e-04 8.381602e-04 16 1784711 1784802 92 + 1.276 0.860 -1.517
ENSG00000095906 E023 110.02713 1.773262e-03 5.051850e-24 5.029206e-22 16 1784803 1785638 836 + 2.221 1.817 -1.357
ENSG00000095906 E024 50.00598 4.979853e-04 4.778882e-07 4.243274e-06 16 1785639 1785726 88 + 1.792 1.517 -0.935
ENSG00000095906 E025 107.64517 4.764526e-04 1.485344e-07 1.459285e-06 16 1785727 1785902 176 + 2.065 1.861 -0.685
ENSG00000095906 E026 124.74292 2.015471e-03 4.987774e-22 3.988682e-20 16 1785903 1786536 634 + 2.255 1.877 -1.266
ENSG00000095906 E027 1076.78474 4.929863e-04 8.110101e-01 8.801402e-01 16 1786537 1786655 119 + 2.894 2.904 0.034
ENSG00000095906 E028 37.05478 5.711274e-04 1.916595e-04 9.281521e-04 16 1786656 1786737 82 + 1.637 1.401 -0.810
ENSG00000095906 E029 23.35465 1.691276e-03 2.844290e-03 9.807297e-03 16 1786738 1786756 19 + 1.449 1.214 -0.821
ENSG00000095906 E030 1116.83589 8.755958e-05 4.771963e-05 2.702225e-04 16 1786757 1786955 199 + 2.856 2.927 0.237
ENSG00000095906 E031 161.74261 4.189651e-03 2.757194e-06 2.081044e-05 16 1786956 1787676 721 + 2.235 2.041 -0.651
ENSG00000095906 E032 1929.60329 5.312704e-04 8.679638e-01 9.190778e-01 16 1787677 1787831 155 + 3.146 3.159 0.043
ENSG00000095906 E033 1851.30096 8.585827e-04 6.000363e-02 1.266067e-01 16 1787941 1788051 111 + 3.100 3.147 0.154
ENSG00000095906 E034 77.41190 1.600696e-03 2.074158e-01 3.354072e-01 16 1788052 1788137 86 + 1.805 1.750 -0.186
ENSG00000095906 E035 1100.98904 5.621579e-04 1.412631e-03 5.348738e-03 16 1788138 1788160 23 + 2.853 2.924 0.235
ENSG00000095906 E036 1261.47851 1.962706e-04 1.431366e-03 5.411348e-03 16 1788161 1788207 47 + 2.921 2.980 0.196
ENSG00000095906 E037 3368.65337 8.816974e-04 5.481421e-10 8.533476e-09 16 1788569 1789186 618 + 3.312 3.415 0.342