ENSG00000095794

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356917 ENSG00000095794 HEK293_OSMI2_2hA HEK293_TMG_2hB CREM protein_coding protein_coding 7.255434 4.391778 12.75224 0.585038 0.7900249 1.535723 0.2431345 0.4109123 0.3806552 0.3107205 0.2263612 -0.1076240 0.04601250 0.10313333 0.02816667 -0.07496667 8.459844e-01 2.397729e-06 FALSE FALSE
ENST00000374726 ENSG00000095794 HEK293_OSMI2_2hA HEK293_TMG_2hB CREM protein_coding protein_coding 7.255434 4.391778 12.75224 0.585038 0.7900249 1.535723 1.1669776 1.5271149 2.6649248 0.1497973 0.8936273 0.7992734 0.15945833 0.36026667 0.21713333 -0.14313333 4.573000e-01 2.397729e-06 FALSE TRUE
ENST00000460270 ENSG00000095794 HEK293_OSMI2_2hA HEK293_TMG_2hB CREM protein_coding protein_coding 7.255434 4.391778 12.75224 0.585038 0.7900249 1.535723 0.4667505 0.1419264 0.9573310 0.1419264 0.1743326 2.6706368 0.05824167 0.03976667 0.07503333 0.03526667 3.580377e-01 2.397729e-06 FALSE FALSE
ENST00000482633 ENSG00000095794 HEK293_OSMI2_2hA HEK293_TMG_2hB CREM protein_coding retained_intron 7.255434 4.391778 12.75224 0.585038 0.7900249 1.535723 0.2811063 0.0000000 0.8716414 0.0000000 0.8716414 6.4621200 0.03827083 0.00000000 0.06083333 0.06083333 1.000000e+00 2.397729e-06   FALSE
ENST00000489388 ENSG00000095794 HEK293_OSMI2_2hA HEK293_TMG_2hB CREM protein_coding processed_transcript 7.255434 4.391778 12.75224 0.585038 0.7900249 1.535723 0.3801782 0.5516160 0.2876994 0.1183874 0.2876994 -0.9157277 0.05775833 0.12426667 0.02413333 -0.10013333 1.065311e-01 2.397729e-06   FALSE
ENST00000496626 ENSG00000095794 HEK293_OSMI2_2hA HEK293_TMG_2hB CREM protein_coding processed_transcript 7.255434 4.391778 12.75224 0.585038 0.7900249 1.535723 0.2202987 0.0000000 0.7116399 0.0000000 0.1157495 6.1732072 0.03080000 0.00000000 0.05516667 0.05516667 2.397729e-06 2.397729e-06   FALSE
MSTRG.3811.12 ENSG00000095794 HEK293_OSMI2_2hA HEK293_TMG_2hB CREM protein_coding   7.255434 4.391778 12.75224 0.585038 0.7900249 1.535723 0.7262251 0.6561466 1.0873162 0.3986656 0.5550308 0.7200676 0.11144167 0.13836667 0.08413333 -0.05423333 9.299850e-01 2.397729e-06 FALSE TRUE
MSTRG.3811.21 ENSG00000095794 HEK293_OSMI2_2hA HEK293_TMG_2hB CREM protein_coding   7.255434 4.391778 12.75224 0.585038 0.7900249 1.535723 0.4756999 0.0000000 0.7832923 0.0000000 0.5141069 6.3097806 0.05492917 0.00000000 0.05733333 0.05733333 3.551312e-01 2.397729e-06 FALSE TRUE
MSTRG.3811.8 ENSG00000095794 HEK293_OSMI2_2hA HEK293_TMG_2hB CREM protein_coding   7.255434 4.391778 12.75224 0.585038 0.7900249 1.535723 0.8899558 0.1045877 1.5236239 0.1045877 0.7627333 3.7424209 0.09191667 0.02560000 0.11733333 0.09173333 6.044439e-01 2.397729e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000095794 E001 0.0000000       10 35126791 35126809 19 +      
ENSG00000095794 E002 0.1817044 0.0542658422 0.210499625   10 35126810 35126840 31 + 0.000 0.173 10.437
ENSG00000095794 E003 0.1817044 0.0542658422 0.210499625   10 35126841 35126845 5 + 0.000 0.173 12.836
ENSG00000095794 E004 0.3332198 0.0381122923 0.544819950   10 35126846 35126872 27 + 0.085 0.173 1.175
ENSG00000095794 E005 0.3332198 0.0381122923 0.544819950   10 35126873 35126905 33 + 0.085 0.173 1.175
ENSG00000095794 E006 0.4502799 0.0313413840 0.314919618 0.457664212 10 35126906 35126922 17 + 0.218 0.000 -13.490
ENSG00000095794 E007 0.6717251 0.0272202195 0.831383750 0.894316106 10 35126923 35126947 25 + 0.217 0.173 -0.408
ENSG00000095794 E008 0.9922594 0.0133327594 0.886372612 0.931329000 10 35126948 35126958 11 + 0.271 0.296 0.176
ENSG00000095794 E009 4.6146262 0.0036734276 0.972050954 0.986527544 10 35126959 35126988 30 + 0.727 0.733 0.023
ENSG00000095794 E010 15.3506602 0.0012567344 0.538927545 0.670268525 10 35126989 35127047 59 + 1.178 1.234 0.196
ENSG00000095794 E011 16.6094188 0.0011316563 0.771008782 0.852179676 10 35127048 35127062 15 + 1.220 1.246 0.092
ENSG00000095794 E012 14.9703247 0.0014300445 0.453664902 0.594408014 10 35127063 35127065 3 + 1.166 1.234 0.241
ENSG00000095794 E013 18.6551588 0.0010952070 0.291111206 0.431940356 10 35127066 35127090 25 + 1.247 1.333 0.300
ENSG00000095794 E014 19.6591721 0.0010490987 0.211674697 0.340459687 10 35127091 35127101 11 + 1.263 1.362 0.344
ENSG00000095794 E015 18.7069668 0.0028573356 0.172603906 0.291593474 10 35127102 35127116 15 + 1.231 1.343 0.392
ENSG00000095794 E016 29.0730055 0.0007622011 0.765919668 0.848579669 10 35127117 35127155 39 + 1.465 1.445 -0.067
ENSG00000095794 E017 27.3973783 0.0007716261 0.929817420 0.959815616 10 35127156 35127161 6 + 1.431 1.438 0.022
ENSG00000095794 E018 35.4225066 0.0006110910 0.514323084 0.649038903 10 35127162 35127193 32 + 1.555 1.516 -0.134
ENSG00000095794 E019 0.1515154 0.0439551055 1.000000000   10 35127424 35127456 33 + 0.085 0.000 -12.004
ENSG00000095794 E020 0.0000000       10 35127457 35127459 3 +      
ENSG00000095794 E021 0.0000000       10 35127460 35127476 17 +      
ENSG00000095794 E022 0.3030308 0.3760539011 0.671649518   10 35127477 35127567 91 + 0.157 0.000 -12.424
ENSG00000095794 E023 3.6038467 0.0117522324 0.123631550 0.225127851 10 35137782 35137835 54 + 0.727 0.470 -1.151
ENSG00000095794 E024 3.2965495 0.0048975613 0.183150544 0.305144063 10 35137836 35137879 44 + 0.690 0.470 -0.997
ENSG00000095794 E025 18.7387688 0.0009575073 0.019402291 0.050205645 10 35148368 35148371 4 + 1.338 1.137 -0.710
ENSG00000095794 E026 24.5378436 0.0007647533 0.013407955 0.036864821 10 35148372 35148400 29 + 1.445 1.258 -0.651
ENSG00000095794 E027 29.3394143 0.0006675770 0.006432621 0.019747226 10 35148401 35148491 91 + 1.522 1.333 -0.653
ENSG00000095794 E028 0.9943357 0.0127860059 0.887452049 0.932060807 10 35148492 35148663 172 + 0.271 0.296 0.176
ENSG00000095794 E029 2.2228062 0.0065635027 0.022692004 0.057114119 10 35152280 35152398 119 + 0.606 0.173 -2.633
ENSG00000095794 E030 0.5922303 0.0179137179 0.825364358 0.890008132 10 35154061 35154565 505 + 0.217 0.173 -0.412
ENSG00000095794 E031 0.0000000       10 35167516 35167538 23 +      
ENSG00000095794 E032 0.0000000       10 35167539 35167725 187 +      
ENSG00000095794 E033 0.0000000       10 35167726 35167803 78 +      
ENSG00000095794 E034 0.3686942 0.0320934210 0.546089370 0.676331140 10 35171193 35171314 122 + 0.085 0.173 1.178
ENSG00000095794 E035 0.0000000       10 35175587 35175592 6 +      
ENSG00000095794 E036 0.0000000       10 35175593 35175595 3 +      
ENSG00000095794 E037 0.0000000       10 35175596 35175597 2 +      
ENSG00000095794 E038 0.0000000       10 35175598 35175705 108 +      
ENSG00000095794 E039 0.1515154 0.0439551055 1.000000000   10 35175853 35175999 147 + 0.085 0.000 -12.004
ENSG00000095794 E040 0.4439371 0.0215967632 0.312570584 0.455091221 10 35178872 35178888 17 + 0.217 0.000 -13.508
ENSG00000095794 E041 45.8538399 0.0004732921 0.755592684 0.840875549 10 35178889 35178986 98 + 1.659 1.644 -0.053
ENSG00000095794 E042 57.4692129 0.0004037765 0.833138648 0.895460266 10 35179134 35179276 143 + 1.747 1.757 0.036
ENSG00000095794 E043 42.9340970 0.0088780276 0.002459552 0.008642653 10 35179277 35179847 571 + 1.547 1.744 0.669
ENSG00000095794 E044 7.7316599 0.0023145865 0.524034622 0.657658156 10 35188200 35188388 189 + 0.944 0.867 -0.295
ENSG00000095794 E045 0.0000000       10 35188389 35188423 35 +      
ENSG00000095794 E046 0.0000000       10 35195127 35195132 6 +      
ENSG00000095794 E047 0.0000000       10 35195133 35195146 14 +      
ENSG00000095794 E048 0.8534295 0.0164924334 0.659020941 0.767963203 10 35195147 35195214 68 + 0.217 0.296 0.591
ENSG00000095794 E049 0.4439371 0.0215967632 0.312570584 0.455091221 10 35195865 35195901 37 + 0.217 0.000 -13.508
ENSG00000095794 E050 0.4439371 0.0215967632 0.312570584 0.455091221 10 35195902 35195908 7 + 0.217 0.000 -13.508
ENSG00000095794 E051 0.4439371 0.0215967632 0.312570584 0.455091221 10 35195909 35195916 8 + 0.217 0.000 -13.508
ENSG00000095794 E052 0.8867284 0.0156662753 0.438416681 0.580300887 10 35195917 35196008 92 + 0.319 0.173 -1.149
ENSG00000095794 E053 0.8814178 0.4508101669 0.234565699 0.367831868 10 35196009 35196099 91 + 0.361 0.000 -13.798
ENSG00000095794 E054 0.0000000       10 35196100 35196142 43 +      
ENSG00000095794 E055 0.0000000       10 35196399 35196539 141 +      
ENSG00000095794 E056 1.2146496 0.0109008423 0.690587339 0.792250881 10 35201451 35201486 36 + 0.319 0.392 0.436
ENSG00000095794 E057 33.1417457 0.0022751686 0.485434756 0.623307657 10 35206895 35207051 157 + 1.533 1.488 -0.155
ENSG00000095794 E058 1.0945577 0.3253827269 0.553507040 0.682621690 10 35209312 35209393 82 + 0.360 0.176 -1.370
ENSG00000095794 E059 58.6271529 0.0005235124 0.878578879 0.926006614 10 35211254 35211655 402 + 1.763 1.757 -0.020
ENSG00000095794 E060 64.7611144 0.0005025540 0.067274834 0.138825518 10 35211656 35212958 1303 + 1.773 1.853 0.272