ENSG00000095787

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000347934 ENSG00000095787 HEK293_OSMI2_2hA HEK293_TMG_2hB WAC protein_coding protein_coding 35.49216 12.12004 57.03941 0.2269048 1.081754 2.233627 0.4991809 0.0000000 3.3815724 0.0000000 0.83351471 8.4058105 0.00882500 0.00000000 0.059300000 0.05930000 4.344276e-08 3.0986e-47 FALSE TRUE
ENST00000354911 ENSG00000095787 HEK293_OSMI2_2hA HEK293_TMG_2hB WAC protein_coding protein_coding 35.49216 12.12004 57.03941 0.2269048 1.081754 2.233627 6.6987071 2.8178237 10.1841937 0.6837021 0.37161519 1.8499836 0.21674583 0.23050000 0.178700000 -0.05180000 7.609021e-01 3.0986e-47 FALSE TRUE
ENST00000424454 ENSG00000095787 HEK293_OSMI2_2hA HEK293_TMG_2hB WAC protein_coding nonsense_mediated_decay 35.49216 12.12004 57.03941 0.2269048 1.081754 2.233627 6.6093866 0.6023965 13.0749238 0.3125245 0.28736316 4.4172958 0.13893750 0.04876667 0.229566667 0.18080000 1.987192e-01 3.0986e-47 FALSE TRUE
ENST00000651598 ENSG00000095787 HEK293_OSMI2_2hA HEK293_TMG_2hB WAC protein_coding protein_coding 35.49216 12.12004 57.03941 0.2269048 1.081754 2.233627 7.0072183 0.0000000 12.9619967 0.0000000 0.58089199 10.3411849 0.14808333 0.00000000 0.227066667 0.22706667 3.098600e-47 3.0986e-47 FALSE TRUE
ENST00000651885 ENSG00000095787 HEK293_OSMI2_2hA HEK293_TMG_2hB WAC protein_coding protein_coding 35.49216 12.12004 57.03941 0.2269048 1.081754 2.233627 2.9076022 0.0000000 5.3240722 0.0000000 1.37759426 9.0590935 0.05332500 0.00000000 0.092766667 0.09276667 1.760947e-10 3.0986e-47 FALSE FALSE
ENST00000679398 ENSG00000095787 HEK293_OSMI2_2hA HEK293_TMG_2hB WAC protein_coding protein_coding 35.49216 12.12004 57.03941 0.2269048 1.081754 2.233627 1.0052591 0.8908297 0.5024865 0.8908297 0.26592735 -0.8137403 0.03029583 0.07636667 0.008633333 -0.06773333 8.996886e-01 3.0986e-47 FALSE TRUE
ENST00000679428 ENSG00000095787 HEK293_OSMI2_2hA HEK293_TMG_2hB WAC protein_coding protein_coding 35.49216 12.12004 57.03941 0.2269048 1.081754 2.233627 0.5143882 1.2318648 0.0000000 0.6274777 0.00000000 -6.9563644 0.03871667 0.09973333 0.000000000 -0.09973333 6.931474e-02 3.0986e-47 FALSE TRUE
MSTRG.3722.33 ENSG00000095787 HEK293_OSMI2_2hA HEK293_TMG_2hB WAC protein_coding   35.49216 12.12004 57.03941 0.2269048 1.081754 2.233627 0.8607973 2.0171159 0.0000000 0.2144662 0.00000000 -7.6632847 0.05829583 0.16723333 0.000000000 -0.16723333 3.785565e-38 3.0986e-47 FALSE TRUE
MSTRG.3722.6 ENSG00000095787 HEK293_OSMI2_2hA HEK293_TMG_2hB WAC protein_coding   35.49216 12.12004 57.03941 0.2269048 1.081754 2.233627 2.1782910 2.9697185 4.0536720 0.5638507 0.03855981 0.4476079 0.11100000 0.24373333 0.071133333 -0.17260000 1.577878e-05 3.0986e-47 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000095787 E001 0.8115992 0.0157809376 5.709631e-01 6.973673e-01 10 28532493 28532748 256 + 0.196 0.326 0.972
ENSG00000095787 E002 1.0319011 0.0119180200 3.912807e-01 5.352074e-01 10 28532749 28532754 6 + 0.330 0.192 -1.029
ENSG00000095787 E003 1.4674191 0.0214957275 1.710439e-01 2.895390e-01 10 28532755 28532767 13 + 0.432 0.192 -1.614
ENSG00000095787 E004 1.6189346 0.0087121221 1.231965e-01 2.245343e-01 10 28532768 28532770 3 + 0.462 0.193 -1.766
ENSG00000095787 E005 2.2413538 0.0081141822 4.767673e-01 6.153782e-01 10 28532771 28532772 2 + 0.515 0.427 -0.444
ENSG00000095787 E006 2.8282736 0.0246045794 2.311802e-01 3.638783e-01 10 28532773 28532775 3 + 0.606 0.427 -0.861
ENSG00000095787 E007 2.9797890 0.0064031591 1.717256e-01 2.904662e-01 10 28532776 28532778 3 + 0.626 0.427 -0.947
ENSG00000095787 E008 6.6552631 0.0156673236 1.599563e-01 2.750590e-01 10 28532779 28532783 5 + 0.893 0.737 -0.615
ENSG00000095787 E009 46.6238414 0.0004930163 1.185616e-05 7.745220e-05 10 28532784 28532886 103 + 1.687 1.478 -0.714
ENSG00000095787 E010 27.9962058 0.0007213114 1.410775e-04 7.082362e-04 10 28532887 28532888 2 + 1.478 1.235 -0.843
ENSG00000095787 E011 60.7408502 0.0004207738 1.529410e-07 1.498861e-06 10 28532889 28533007 119 + 1.804 1.578 -0.765
ENSG00000095787 E012 38.5113484 0.0185427729 6.411716e-01 7.542724e-01 10 28533118 28533312 195 + 1.548 1.563 0.052
ENSG00000095787 E013 40.2518290 0.0023400477 4.246253e-02 9.555507e-02 10 28533313 28533370 58 + 1.593 1.517 -0.259
ENSG00000095787 E014 60.8992854 0.0213227348 3.728372e-03 1.237849e-02 10 28533371 28533499 129 + 1.797 1.598 -0.677
ENSG00000095787 E015 12.4889414 0.0183649871 4.024817e-04 1.784060e-03 10 28533500 28533500 1 + 1.178 0.739 -1.651
ENSG00000095787 E016 14.3712651 0.0163424964 3.708758e-04 1.661809e-03 10 28533501 28533505 5 + 1.229 0.820 -1.510
ENSG00000095787 E017 29.4394593 0.0221526665 2.225104e-05 1.364779e-04 10 28533506 28533539 34 + 1.527 1.108 -1.467
ENSG00000095787 E018 49.3095652 0.0023443628 2.988764e-11 5.758873e-10 10 28533540 28533582 43 + 1.744 1.347 -1.361
ENSG00000095787 E019 43.8263076 0.0067752401 3.551761e-06 2.615426e-05 10 28533583 28533596 14 + 1.679 1.378 -1.028
ENSG00000095787 E020 51.5306391 0.0013091477 6.284808e-09 8.052865e-08 10 28533597 28533620 24 + 1.748 1.444 -1.038
ENSG00000095787 E021 0.0000000       10 28533749 28533762 14 +      
ENSG00000095787 E022 1.7238122 0.4008345581 8.294898e-01 8.929367e-01 10 28533763 28533893 131 + 0.404 0.424 0.109
ENSG00000095787 E023 2.9082609 0.0776398085 2.867462e-01 4.271632e-01 10 28533894 28533997 104 + 0.607 0.426 -0.867
ENSG00000095787 E024 97.2842039 0.0066352284 4.518429e-07 4.031473e-06 10 28533998 28534034 37 + 2.010 1.770 -0.806
ENSG00000095787 E025 1.1479275 0.0465738387 9.696104e-01 9.849899e-01 10 28534035 28534122 88 + 0.290 0.326 0.240
ENSG00000095787 E026 1.1781165 0.1425360239 4.423259e-01 5.839637e-01 10 28534123 28534182 60 + 0.245 0.431 1.159
ENSG00000095787 E027 2.4766410 0.0214695388 3.370198e-01 4.808834e-01 10 28534234 28534346 113 + 0.433 0.639 0.975
ENSG00000095787 E028 1.6198770 0.1869020208 7.613027e-01 8.452143e-01 10 28535266 28535543 278 + 0.366 0.499 0.702
ENSG00000095787 E029 26.5759945 0.0087850372 1.083609e-03 4.248117e-03 10 28535544 28535561 18 + 1.461 1.219 -0.842
ENSG00000095787 E030 193.0985699 0.0028163911 1.129411e-08 1.378720e-07 10 28535562 28535685 124 + 2.288 2.123 -0.552
ENSG00000095787 E031 174.2145028 0.0011371535 7.929169e-08 8.213447e-07 10 28535686 28535757 72 + 2.235 2.108 -0.422
ENSG00000095787 E032 1.1907914 0.2477315378 9.911559e-02 1.891295e-01 10 28535758 28535909 152 + 0.402 0.000 -11.240
ENSG00000095787 E033 0.4460135 0.0313989390 3.572889e-01 5.016908e-01 10 28535910 28535918 9 + 0.196 0.000 -10.651
ENSG00000095787 E034 0.4460135 0.0313989390 3.572889e-01 5.016908e-01 10 28535919 28536059 141 + 0.196 0.000 -10.651
ENSG00000095787 E035 1.3380524 0.0136462543 6.891118e-01 7.910501e-01 10 28537584 28537815 232 + 0.367 0.325 -0.253
ENSG00000095787 E036 0.4482035 0.0285690544 3.570935e-01 5.015107e-01 10 28537950 28538066 117 + 0.196 0.000 -10.673
ENSG00000095787 E037 111.9226264 0.0003292432 6.054833e-05 3.341796e-04 10 28583399 28583405 7 + 2.037 1.942 -0.317
ENSG00000095787 E038 226.4622798 0.0001744117 7.284995e-09 9.206327e-08 10 28583406 28583505 100 + 2.341 2.245 -0.321
ENSG00000095787 E039 2.3838840 0.0638392117 5.329388e-01 6.652105e-01 10 28588737 28589735 999 + 0.516 0.429 -0.439
ENSG00000095787 E040 251.6979141 0.0004556371 7.627102e-10 1.155668e-08 10 28589736 28589851 116 + 2.389 2.283 -0.355
ENSG00000095787 E041 128.4447959 0.0004074999 4.372632e-09 5.757851e-08 10 28590720 28590721 2 + 2.111 1.953 -0.531
ENSG00000095787 E042 242.6046818 0.0021006531 1.912047e-04 9.262815e-04 10 28590722 28590832 111 + 2.364 2.298 -0.220
ENSG00000095787 E043 1.9281046 0.1652044805 7.041052e-01 8.027068e-01 10 28590833 28591833 1001 + 0.401 0.567 0.822
ENSG00000095787 E044 1.8551416 0.0075847645 3.586363e-01 5.030286e-01 10 28595695 28595732 38 + 0.462 0.326 -0.765
ENSG00000095787 E045 307.7481911 0.0002895906 1.587552e-02 4.245821e-02 10 28595733 28596041 309 + 2.446 2.450 0.014
ENSG00000095787 E046 273.2991472 0.0001999897 3.425126e-01 4.865064e-01 10 28608186 28608345 160 + 2.384 2.422 0.125
ENSG00000095787 E047 175.0620760 0.0001871771 5.465649e-01 6.767272e-01 10 28608346 28608431 86 + 2.180 2.257 0.258
ENSG00000095787 E048 0.7728905 0.0143658165 6.869263e-01 7.893592e-01 10 28608432 28608593 162 + 0.245 0.193 -0.443
ENSG00000095787 E049 79.6673129 0.0006356422 1.946668e-02 5.034406e-02 10 28610699 28610707 9 + 1.815 1.974 0.535
ENSG00000095787 E050 79.4983085 0.0004720074 2.980503e-02 7.158035e-02 10 28610708 28610710 3 + 1.818 1.969 0.509
ENSG00000095787 E051 212.5976500 0.0002423109 5.792757e-01 7.042060e-01 10 28610711 28610821 111 + 2.265 2.340 0.249
ENSG00000095787 E052 9.1473237 0.0023622027 8.686224e-03 2.550178e-02 10 28610822 28611254 433 + 1.028 0.738 -1.115
ENSG00000095787 E053 13.6788164 0.0070176114 3.593248e-01 5.036662e-01 10 28611255 28611481 227 + 1.143 1.104 -0.142
ENSG00000095787 E054 9.4946238 0.0017252522 1.164632e-01 2.149067e-01 10 28611482 28611773 292 + 1.021 0.886 -0.503
ENSG00000095787 E055 304.3245969 0.0001496989 1.303300e-01 2.346148e-01 10 28611774 28611922 149 + 2.435 2.462 0.088
ENSG00000095787 E056 271.7645912 0.0005652676 9.399850e-01 9.663201e-01 10 28614567 28614685 119 + 2.376 2.434 0.194
ENSG00000095787 E057 5.3028157 0.0032894597 1.823368e-02 4.764115e-02 10 28614686 28614998 313 + 0.838 0.510 -1.397
ENSG00000095787 E058 5.2222742 0.0073371196 1.698417e-01 2.880084e-01 10 28614999 28615327 329 + 0.800 0.638 -0.665
ENSG00000095787 E059 5.3969720 0.0030668651 4.444067e-02 9.918654e-02 10 28615328 28615573 246 + 0.838 0.579 -1.076
ENSG00000095787 E060 5.4288985 0.0479130007 2.084652e-01 3.366273e-01 10 28615574 28616172 599 + 0.814 0.639 -0.717
ENSG00000095787 E061 87.2638054 0.0003074745 5.464846e-01 6.766525e-01 10 28616173 28616175 3 + 1.879 1.964 0.283
ENSG00000095787 E062 333.9051717 0.0001549177 1.192222e-01 2.188276e-01 10 28616176 28616362 187 + 2.453 2.546 0.308
ENSG00000095787 E063 282.1922446 0.0009999169 5.110905e-04 2.201309e-03 10 28617657 28617784 128 + 2.360 2.511 0.503
ENSG00000095787 E064 1.4621191 0.0850362547 7.303881e-01 8.223600e-01 10 28617785 28618041 257 + 0.330 0.429 0.570
ENSG00000095787 E065 1217.4146465 0.0041298106 1.814971e-24 1.889235e-22 10 28619537 28623112 3576 + 2.921 3.249 1.092