ENSG00000095739

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375533 ENSG00000095739 HEK293_OSMI2_2hA HEK293_TMG_2hB BAMBI protein_coding protein_coding 10.98689 10.90651 13.07524 0.7827177 0.2293155 0.2614284 10.3617628 10.5508732 11.98743 0.7368680 0.2469322 0.1839962 0.94366667 0.96766667 0.91676667 -0.0509 0.02538412 0.02538412 FALSE  
ENST00000497699 ENSG00000095739 HEK293_OSMI2_2hA HEK293_TMG_2hB BAMBI protein_coding retained_intron 10.98689 10.90651 13.07524 0.7827177 0.2293155 0.2614284 0.6251264 0.3556376 1.08781 0.1060766 0.1005099 1.5861414 0.05633333 0.03233333 0.08323333 0.0509 0.02576092 0.02538412 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000095739 E001 9.032875 0.0047703789 0.0261120515 0.064172296 10 28677510 28677520 11 + 1.120 0.881 -0.885
ENSG00000095739 E002 93.879236 0.0048518830 0.0627492493 0.131282794 10 28677521 28677973 453 + 2.021 1.933 -0.294
ENSG00000095739 E003 192.780642 0.0002830352 0.9613243159 0.979640180 10 28681258 28681545 288 + 2.291 2.292 0.003
ENSG00000095739 E004 7.571512 0.0023297904 0.0004160756 0.001836112 10 28681546 28681982 437 + 1.109 0.696 -1.581
ENSG00000095739 E005 352.544853 0.0008813492 0.0049752366 0.015861063 10 28681983 28682932 950 + 2.528 2.569 0.136