ENSG00000095713

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000309155 ENSG00000095713 HEK293_OSMI2_2hA HEK293_TMG_2hB CRTAC1 protein_coding protein_coding 3.162217 4.959794 1.500323 0.3130877 0.0476392 -1.718329 0.96975205 1.9862643 0.38610846 0.2881272 0.21292933 -2.333335 0.30398750 0.3965 0.2539667 -0.14253333 0.672708762 0.002773344 FALSE  
ENST00000370597 ENSG00000095713 HEK293_OSMI2_2hA HEK293_TMG_2hB CRTAC1 protein_coding protein_coding 3.162217 4.959794 1.500323 0.3130877 0.0476392 -1.718329 1.60453384 2.3790753 0.76889358 0.2038322 0.12539469 -1.616954 0.50120000 0.4787 0.5122333 0.03353333 0.900097160 0.002773344 FALSE  
ENST00000436034 ENSG00000095713 HEK293_OSMI2_2hA HEK293_TMG_2hB CRTAC1 protein_coding protein_coding 3.162217 4.959794 1.500323 0.3130877 0.0476392 -1.718329 0.15653899 0.3213137 0.00000000 0.0299267 0.00000000 -5.050126 0.04519583 0.0655 0.0000000 -0.06550000 0.002773344 0.002773344 FALSE  
MSTRG.4462.5 ENSG00000095713 HEK293_OSMI2_2hA HEK293_TMG_2hB CRTAC1 protein_coding   3.162217 4.959794 1.500323 0.3130877 0.0476392 -1.718329 0.18194515 0.2731402 0.04897168 0.1549566 0.04897168 -2.263422 0.07567083 0.0593 0.0309000 -0.02840000 0.810592201 0.002773344 FALSE  
MSTRG.4462.8 ENSG00000095713 HEK293_OSMI2_2hA HEK293_TMG_2hB CRTAC1 protein_coding   3.162217 4.959794 1.500323 0.3130877 0.0476392 -1.718329 0.04656553 0.0000000 0.26148367 0.0000000 0.14119505 4.762794 0.02531667 0.0000 0.1783667 0.17836667 0.076120043 0.002773344 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000095713 E001 0.1451727 0.0424147327 0.120484781   10 97854777 97854941 165 - 0.210 0.000 -10.690
ENSG00000095713 E002 32.8968343 0.0007144416 0.899455227 0.93985811 10 97865000 97865714 715 - 1.414 1.423 0.030
ENSG00000095713 E003 1.3994719 0.0096765512 0.099170492 0.18921326 10 97878397 97878502 106 - 0.000 0.372 12.077
ENSG00000095713 E004 3.2073048 0.0251085654 0.058420981 0.12392153 10 97878503 97878689 187 - 0.211 0.606 2.282
ENSG00000095713 E005 0.4407149 0.0229690676 0.094153896 0.18162648 10 97879629 97879650 22 - 0.352 0.068 -2.879
ENSG00000095713 E006 0.6234634 0.0193035480 0.859522316 0.91337595 10 97879651 97879801 151 - 0.211 0.178 -0.295
ENSG00000095713 E007 8.3112977 0.0021042397 0.017188956 0.04536002 10 97880249 97880284 36 - 0.543 0.919 1.549
ENSG00000095713 E008 13.7485145 0.0013860145 0.411078597 0.55467196 10 97880285 97880345 61 - 0.988 1.080 0.338
ENSG00000095713 E009 13.5732441 0.0014524335 0.406665027 0.55029393 10 97880346 97880392 47 - 1.130 1.042 -0.317
ENSG00000095713 E010 15.2036375 0.0012438481 0.968006201 0.98400399 10 97882786 97882828 43 - 1.109 1.104 -0.017
ENSG00000095713 E011 27.3920737 0.0008533536 0.104482357 0.19732381 10 97884206 97884351 146 - 1.444 1.323 -0.421
ENSG00000095713 E012 0.1817044 0.0390850401 1.000000000   10 97884352 97884548 197 - 0.000 0.068 9.256
ENSG00000095713 E013 27.7810176 0.0008021709 0.023135027 0.05802875 10 97895245 97895413 169 - 1.482 1.316 -0.574
ENSG00000095713 E014 19.7658439 0.0009821009 0.301030795 0.44280564 10 97895885 97895985 101 - 1.281 1.189 -0.325
ENSG00000095713 E015 17.2152103 0.0011319464 0.359583679 0.50391349 10 97896909 97896991 83 - 1.220 1.133 -0.311
ENSG00000095713 E016 22.7626523 0.0009334390 0.087417013 0.17122509 10 97901503 97901639 137 - 1.370 1.230 -0.491
ENSG00000095713 E017 0.1451727 0.0424147327 0.120484781   10 97901640 97901654 15 - 0.210 0.000 -13.137
ENSG00000095713 E018 34.1903101 0.0015643353 0.005755053 0.01796766 10 97904669 97904814 146 - 1.236 1.461 0.783
ENSG00000095713 E019 35.1731104 0.0007656623 0.328004520 0.47145983 10 97908013 97908147 135 - 1.382 1.453 0.246
ENSG00000095713 E020 45.6693446 0.0005875286 0.037859381 0.08708637 10 97917500 97917656 157 - 1.444 1.580 0.465
ENSG00000095713 E021 45.1669197 0.0005396490 0.401421031 0.54512358 10 97923264 97923400 137 - 1.508 1.560 0.180
ENSG00000095713 E022 44.5958066 0.0006806780 0.798044751 0.87112976 10 97936170 97936366 197 - 1.532 1.548 0.054
ENSG00000095713 E023 38.1332905 0.0087204723 0.365305894 0.50964223 10 98011138 98011337 200 - 1.532 1.466 -0.228
ENSG00000095713 E024 13.9535400 0.0014236458 0.197788466 0.32346992 10 98030449 98030828 380 - 1.168 1.036 -0.478