ENSG00000095637

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306402 ENSG00000095637 HEK293_OSMI2_2hA HEK293_TMG_2hB SORBS1 protein_coding protein_coding 1.137478 1.20873 1.004162 0.06686974 0.04513178 -0.2650911 0.24060447 0.1593387 0.31397149 0.08149754 0.08071934 0.9359552 0.21785833 0.1379000 0.31603333 0.17813333 4.589142e-01 1.45253e-08 FALSE TRUE
ENST00000371241 ENSG00000095637 HEK293_OSMI2_2hA HEK293_TMG_2hB SORBS1 protein_coding protein_coding 1.137478 1.20873 1.004162 0.06686974 0.04513178 -0.2650911 0.06966625 0.0000000 0.05390908 0.00000000 0.03135344 2.6760210 0.05400833 0.0000000 0.05586667 0.05586667 2.375480e-01 1.45253e-08 FALSE TRUE
ENST00000371249 ENSG00000095637 HEK293_OSMI2_2hA HEK293_TMG_2hB SORBS1 protein_coding protein_coding 1.137478 1.20873 1.004162 0.06686974 0.04513178 -0.2650911 0.46576940 0.2650815 0.58669332 0.10897068 0.10561266 1.1171306 0.41154583 0.2255333 0.58033333 0.35480000 1.539118e-01 1.45253e-08 FALSE TRUE
ENST00000649911 ENSG00000095637 HEK293_OSMI2_2hA HEK293_TMG_2hB SORBS1 protein_coding protein_coding 1.137478 1.20873 1.004162 0.06686974 0.04513178 -0.2650911 0.23096665 0.6869911 0.00000000 0.13807308 0.00000000 -6.1230683 0.21141250 0.5589333 0.00000000 -0.55893333 1.452530e-08 1.45253e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000095637 E001 0.0000000       10 95311771 95311772 2 -      
ENSG00000095637 E002 0.0000000       10 95311773 95311773 1 -      
ENSG00000095637 E003 98.4920445 0.009524512 7.012255e-08 7.334238e-07 10 95311774 95314734 2961 - 1.847 2.114 0.896
ENSG00000095637 E004 4.9779212 0.003435969 1.956594e-01 3.207910e-01 10 95314735 95314736 2 - 0.833 0.700 -0.533
ENSG00000095637 E005 12.2973218 0.003324038 9.525857e-01 9.743119e-01 10 95314737 95315024 288 - 1.101 1.139 0.138
ENSG00000095637 E006 4.0106659 0.004090662 7.581015e-01 8.427616e-01 10 95315025 95315058 34 - 0.705 0.700 -0.019
ENSG00000095637 E007 4.7147449 0.003938290 3.264414e-01 4.698824e-01 10 95315059 95315126 68 - 0.794 0.700 -0.380
ENSG00000095637 E008 4.8284821 0.003919174 2.558248e-01 3.927555e-01 10 95318320 95318432 113 - 0.814 0.700 -0.459
ENSG00000095637 E009 5.0226815 0.143527391 6.248043e-01 7.410554e-01 10 95321963 95322021 59 - 0.730 0.831 0.405
ENSG00000095637 E010 0.1817044 0.039726173 4.354906e-01   10 95322022 95322153 132 - 0.000 0.135 10.966
ENSG00000095637 E011 1.3973836 0.010218656 1.106457e-01 2.064789e-01 10 95322746 95322805 60 - 0.199 0.504 1.915
ENSG00000095637 E012 0.2214452 0.040990368 4.342225e-01   10 95336521 95336805 285 - 0.000 0.135 10.966
ENSG00000095637 E013 0.0000000       10 95336806 95337294 489 -      
ENSG00000095637 E014 8.0930348 0.026323560 6.822043e-01 7.856868e-01 10 95339133 95339327 195 - 0.917 1.004 0.327
ENSG00000095637 E015 5.4546248 0.184899229 8.838178e-01 9.297128e-01 10 95341285 95341410 126 - 0.772 0.854 0.321
ENSG00000095637 E016 2.8176750 0.079345058 3.715347e-01 5.159857e-01 10 95341564 95341583 20 - 0.651 0.503 -0.668
ENSG00000095637 E017 3.6250314 0.075252613 8.065340e-01 8.770561e-01 10 95341584 95341673 90 - 0.622 0.702 0.341
ENSG00000095637 E018 1.2019878 0.347010088 1.570323e-01 2.711556e-01 10 95341674 95341678 5 - 0.111 0.503 2.915
ENSG00000095637 E019 2.5024618 0.006251727 3.212675e-01 4.645050e-01 10 95346406 95346452 47 - 0.438 0.632 0.914
ENSG00000095637 E020 1.5123673 0.009347873 6.138635e-01 7.324721e-01 10 95351209 95351215 7 - 0.335 0.451 0.652
ENSG00000095637 E021 3.5858587 0.005092507 5.629019e-01 6.904507e-01 10 95351216 95351376 161 - 0.679 0.632 -0.201
ENSG00000095637 E022 3.6975315 0.005078535 9.500086e-01 9.727081e-01 10 95354882 95354967 86 - 0.652 0.700 0.203
ENSG00000095637 E023 0.0000000       10 95355627 95357105 1479 -      
ENSG00000095637 E024 4.0847614 0.004116190 9.257856e-01 9.572799e-01 10 95357631 95357803 173 - 0.679 0.731 0.214
ENSG00000095637 E025 2.3864353 0.006501249 6.342446e-01 7.487722e-01 10 95367650 95367699 50 - 0.482 0.593 0.521
ENSG00000095637 E026 0.1515154 0.044915008 5.453347e-01   10 95371326 95371427 102 - 0.111 0.000 -10.921
ENSG00000095637 E027 0.0000000       10 95371984 95372049 66 -      
ENSG00000095637 E028 0.5901540 0.021230458 3.694562e-01 5.138723e-01 10 95375973 95376056 84 - 0.272 0.135 -1.257
ENSG00000095637 E029 0.0000000       10 95381413 95381684 272 -      
ENSG00000095637 E030 5.5807872 0.014442020 1.988754e-01 3.247962e-01 10 95381685 95381799 115 - 0.885 0.758 -0.500
ENSG00000095637 E031 3.6715984 0.034490078 9.688954e-02 1.857387e-01 10 95383985 95384050 66 - 0.774 0.549 -0.962
ENSG00000095637 E032 3.8533028 0.018084772 1.398849e-01 2.478673e-01 10 95384051 95384114 64 - 0.774 0.592 -0.764
ENSG00000095637 E033 3.5042731 0.004614796 9.600242e-01 9.788896e-01 10 95384238 95384285 48 - 0.623 0.667 0.193
ENSG00000095637 E034 0.0000000       10 95386991 95387119 129 -      
ENSG00000095637 E035 0.0000000       10 95394611 95394673 63 -      
ENSG00000095637 E036 0.0000000       10 95395001 95395075 75 -      
ENSG00000095637 E037 4.9445220 0.003348528 5.646991e-01 6.919381e-01 10 95397220 95397283 64 - 0.794 0.759 -0.141
ENSG00000095637 E038 7.6770675 0.011012643 9.463214e-02 1.823315e-01 10 95399017 95399189 173 - 1.012 0.857 -0.586
ENSG00000095637 E039 3.5793150 0.004557949 7.252864e-01 8.186030e-01 10 95406118 95406147 30 - 0.679 0.667 -0.051
ENSG00000095637 E040 5.1755624 0.007024934 1.536099e-02 4.130749e-02 10 95410633 95410777 145 - 0.917 0.631 -1.147
ENSG00000095637 E041 0.0000000       10 95413553 95413764 212 -      
ENSG00000095637 E042 2.5713514 0.006612576 1.410438e-01 2.494683e-01 10 95414494 95414655 162 - 0.652 0.451 -0.935
ENSG00000095637 E043 1.3618986 0.010049606 4.070108e-01 5.506383e-01 10 95414656 95414743 88 - 0.438 0.321 -0.672
ENSG00000095637 E044 2.3238673 0.006710540 5.822211e-01 7.066167e-01 10 95414744 95414862 119 - 0.558 0.503 -0.257
ENSG00000095637 E045 0.0000000       10 95415469 95416185 717 -      
ENSG00000095637 E046 3.5805376 0.004371884 1.239415e-02 3.448226e-02 10 95421961 95422073 113 - 0.794 0.451 -1.519
ENSG00000095637 E047 2.0680671 0.068343512 1.234207e-01 2.248282e-01 10 95422190 95422216 27 - 0.592 0.322 -1.399
ENSG00000095637 E048 6.2439435 0.029367904 2.321949e-03 8.219379e-03 10 95432448 95432576 129 - 1.013 0.594 -1.666
ENSG00000095637 E049 0.0000000       10 95434622 95434717 96 -      
ENSG00000095637 E050 3.9866965 0.023972597 6.634508e-03 2.027500e-02 10 95437490 95437555 66 - 0.851 0.451 -1.742
ENSG00000095637 E051 3.7235333 0.004552756 8.106889e-03 2.405290e-02 10 95441126 95441180 55 - 0.814 0.451 -1.596
ENSG00000095637 E052 0.0000000       10 95482434 95482671 238 -      
ENSG00000095637 E053 0.0000000       10 95490737 95491034 298 -      
ENSG00000095637 E054 3.9093904 0.071335252 6.330420e-02 1.322117e-01 10 95491035 95491120 86 - 0.814 0.505 -1.328
ENSG00000095637 E055 0.0000000       10 95493165 95493185 21 -      
ENSG00000095637 E056 1.6898079 0.016037846 1.908309e-01 3.147871e-01 10 95561320 95561414 95 - 0.521 0.321 -1.086