ENSG00000095574

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368886 ENSG00000095574 HEK293_OSMI2_2hA HEK293_TMG_2hB IKZF5 protein_coding protein_coding 10.54394 2.906052 17.41524 0.2703099 0.813766 2.57909 3.7074786 1.3570972 7.2672756 0.34977350 0.5834740 2.41228264 0.40335417 0.47933333 0.41923333 -0.06010000 0.89818071 0.01964236 FALSE TRUE
ENST00000479103 ENSG00000095574 HEK293_OSMI2_2hA HEK293_TMG_2hB IKZF5 protein_coding processed_transcript 10.54394 2.906052 17.41524 0.2703099 0.813766 2.57909 0.8696516 0.1278779 1.6782706 0.05126461 0.1733099 3.61408292 0.07843333 0.04806667 0.09773333 0.04966667 0.27178749 0.01964236   FALSE
ENST00000617859 ENSG00000095574 HEK293_OSMI2_2hA HEK293_TMG_2hB IKZF5 protein_coding protein_coding 10.54394 2.906052 17.41524 0.2703099 0.813766 2.57909 1.2596748 0.7216428 0.6951973 0.60682556 0.5628982 -0.05311243 0.15059583 0.22236667 0.03806667 -0.18430000 0.71319576 0.01964236 FALSE TRUE
MSTRG.4765.3 ENSG00000095574 HEK293_OSMI2_2hA HEK293_TMG_2hB IKZF5 protein_coding   10.54394 2.906052 17.41524 0.2703099 0.813766 2.57909 1.0342902 0.0000000 0.3868659 0.00000000 0.3868659 5.31057966 0.08155417 0.00000000 0.02433333 0.02433333 1.00000000 0.01964236 FALSE TRUE
MSTRG.4765.4 ENSG00000095574 HEK293_OSMI2_2hA HEK293_TMG_2hB IKZF5 protein_coding   10.54394 2.906052 17.41524 0.2703099 0.813766 2.57909 2.4082230 0.4012086 5.4967536 0.09134417 0.4286547 3.74325986 0.18855833 0.14333333 0.31510000 0.17176667 0.01964236 0.01964236 FALSE TRUE
MSTRG.4765.7 ENSG00000095574 HEK293_OSMI2_2hA HEK293_TMG_2hB IKZF5 protein_coding   10.54394 2.906052 17.41524 0.2703099 0.813766 2.57909 0.4329145 0.0000000 1.0717210 0.00000000 0.5506175 6.75718465 0.02178750 0.00000000 0.05876667 0.05876667 0.43553960 0.01964236 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000095574 E001 0.1482932 0.0411597534 1.019302e-01   10 122990807 122990807 1 - 0.000 0.225 11.526
ENSG00000095574 E002 151.8429345 0.0085506891 1.391545e-06 1.120041e-05 10 122990808 122992112 1305 - 2.030 2.298 0.897
ENSG00000095574 E003 35.3134125 0.0007452595 8.030524e-03 2.385759e-02 10 122992113 122992162 50 - 1.510 1.330 -0.621
ENSG00000095574 E004 24.3824915 0.0051169537 1.908721e-03 6.942927e-03 10 122992163 122992167 5 - 1.370 1.075 -1.045
ENSG00000095574 E005 34.6668079 0.0006846175 3.315711e-03 1.119380e-02 10 122992168 122992236 69 - 1.508 1.301 -0.713
ENSG00000095574 E006 225.9072638 0.0002281831 3.038445e-01 4.458299e-01 10 122992237 122993879 1643 - 2.263 2.315 0.173
ENSG00000095574 E007 179.9862024 0.0003508334 2.736123e-01 4.126762e-01 10 122993880 122994537 658 - 2.178 2.171 -0.024
ENSG00000095574 E008 73.8771115 0.0019962300 8.420380e-02 1.661423e-01 10 122994538 122994691 154 - 1.807 1.738 -0.235
ENSG00000095574 E009 43.4838283 0.0005480522 1.822801e-02 4.763091e-02 10 122994692 122994723 32 - 1.595 1.460 -0.462
ENSG00000095574 E010 77.4196453 0.0003436031 3.383163e-01 4.821706e-01 10 122995994 122996146 153 - 1.819 1.798 -0.070
ENSG00000095574 E011 38.6979800 0.0005688154 5.068315e-01 6.424738e-01 10 122996147 122996176 30 - 1.520 1.499 -0.071
ENSG00000095574 E012 9.4019697 0.0062610283 1.441854e-02 3.917523e-02 10 122998227 122998492 266 - 0.995 0.643 -1.387
ENSG00000095574 E013 76.0128061 0.0004716929 5.938371e-01 7.161450e-01 10 122998493 122998658 166 - 1.804 1.803 -0.004
ENSG00000095574 E014 29.3523158 0.0010369376 4.486487e-01 5.899243e-01 10 122998659 122998671 13 - 1.406 1.370 -0.126
ENSG00000095574 E015 0.8964071 0.1548272709 2.930074e-01 4.340501e-01 10 123006240 123006275 36 - 0.287 0.000 -13.691
ENSG00000095574 E016 43.8414179 0.0269207039 6.100590e-01 7.294348e-01 10 123007026 123007176 151 - 1.553 1.613 0.205
ENSG00000095574 E017 0.7447779 0.1179766468 3.499219e-01 4.941202e-01 10 123007617 123007667 51 - 0.251 0.000 -13.553
ENSG00000095574 E018 0.7374030 0.0155870768 1.000000e+00 1.000000e+00 10 123008266 123008298 33 - 0.210 0.225 0.122
ENSG00000095574 E019 2.0898384 0.0379573542 8.689458e-01 9.197809e-01 10 123008575 123008693 119 - 0.433 0.481 0.245
ENSG00000095574 E020 23.7628850 0.0985992823 9.144926e-01 9.498812e-01 10 123008694 123008891 198 - 1.304 1.333 0.100