ENSG00000095564

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265990 ENSG00000095564 HEK293_OSMI2_2hA HEK293_TMG_2hB BTAF1 protein_coding protein_coding 10.0304 2.531013 16.07214 0.2543375 0.2604086 2.661983 5.2364087 1.682694357 7.4783646 0.199562814 0.08209416 2.145329 0.5351292 0.671833333 0.46556667 -0.2062667 7.152320e-02 1.484311e-12 FALSE TRUE
MSTRG.4377.1 ENSG00000095564 HEK293_OSMI2_2hA HEK293_TMG_2hB BTAF1 protein_coding   10.0304 2.531013 16.07214 0.2543375 0.2604086 2.661983 1.6550720 0.007505906 4.7200906 0.007505906 0.48806113 8.077882 0.1021042 0.002766667 0.29380000 0.2910333 1.484311e-12 1.484311e-12 FALSE TRUE
MSTRG.4377.3 ENSG00000095564 HEK293_OSMI2_2hA HEK293_TMG_2hB BTAF1 protein_coding   10.0304 2.531013 16.07214 0.2543375 0.2604086 2.661983 0.7322453 0.818130606 0.2871963 0.251099580 0.19296093 -1.478442 0.1922833 0.315466667 0.01763333 -0.2978333 4.224256e-03 1.484311e-12 FALSE TRUE
MSTRG.4377.5 ENSG00000095564 HEK293_OSMI2_2hA HEK293_TMG_2hB BTAF1 protein_coding   10.0304 2.531013 16.07214 0.2543375 0.2604086 2.661983 2.2964671 0.019878849 3.3282204 0.010192300 0.10775841 6.803811 0.1610542 0.008566667 0.20713333 0.1985667 1.989517e-12 1.484311e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000095564 E001 4.4458279 0.0036665110 3.832770e-03 1.267271e-02 10 91923770 91923807 38 + 0.670 0.000 -11.833
ENSG00000095564 E002 17.6225553 0.0010457853 7.935063e-07 6.735098e-06 10 91923808 91923846 39 + 1.186 0.436 -3.056
ENSG00000095564 E003 20.0155263 0.0009747133 7.423494e-07 6.341945e-06 10 91923847 91923867 21 + 1.235 0.555 -2.645
ENSG00000095564 E004 19.5715892 0.0010058708 1.134667e-06 9.311642e-06 10 91923868 91923873 6 + 1.226 0.555 -2.612
ENSG00000095564 E005 35.5056017 0.0013582721 1.602980e-09 2.287434e-08 10 91923874 91924090 217 + 1.469 0.848 -2.236
ENSG00000095564 E006 27.9699757 0.0019787033 7.336581e-03 2.209336e-02 10 91935657 91935780 124 + 1.340 1.145 -0.687
ENSG00000095564 E007 36.2549480 0.0005509678 5.587499e-02 1.194721e-01 10 91939952 91940066 115 + 1.433 1.354 -0.276
ENSG00000095564 E008 53.3488416 0.0009704230 1.142179e-05 7.490134e-05 10 91942422 91942568 147 + 1.617 1.354 -0.903
ENSG00000095564 E009 26.1409396 0.0007106201 1.448922e-03 5.469859e-03 10 91951403 91951408 6 + 1.320 1.055 -0.940
ENSG00000095564 E010 66.0959971 0.0004137011 1.413863e-07 1.395790e-06 10 91951409 91951566 158 + 1.709 1.416 -1.003
ENSG00000095564 E011 70.3375085 0.0004481086 3.487877e-09 4.677008e-08 10 91953737 91953873 137 + 1.739 1.401 -1.156
ENSG00000095564 E012 57.8047599 0.0091433655 2.297116e-04 1.090681e-03 10 91956528 91956620 93 + 1.648 1.403 -0.839
ENSG00000095564 E013 38.6306810 0.0129857714 2.634186e-02 6.463226e-02 10 91956621 91956657 37 + 1.467 1.322 -0.501
ENSG00000095564 E014 54.3804655 0.0047444133 4.527729e-07 4.038821e-06 10 91957225 91957293 69 + 1.632 1.263 -1.272
ENSG00000095564 E015 71.8551769 0.0003789812 3.296528e-09 4.438330e-08 10 91959065 91959154 90 + 1.748 1.416 -1.134
ENSG00000095564 E016 20.8163449 0.0058142061 5.024441e-01 6.385058e-01 10 91959155 91959282 128 + 1.190 1.196 0.023
ENSG00000095564 E017 63.6562695 0.0027039929 3.740995e-04 1.673958e-03 10 91959785 91959880 96 + 1.681 1.507 -0.594
ENSG00000095564 E018 67.3496394 0.0003568755 4.219233e-05 2.418713e-04 10 91959978 91960154 177 + 1.708 1.518 -0.648
ENSG00000095564 E019 48.2511056 0.0176691297 6.708799e-02 1.385208e-01 10 91962538 91962678 141 + 1.560 1.457 -0.351
ENSG00000095564 E020 64.4338515 0.0070901978 1.986256e-03 7.183578e-03 10 91964077 91964201 125 + 1.689 1.529 -0.543
ENSG00000095564 E021 36.6268936 0.0005474181 1.575672e-02 4.218873e-02 10 91966637 91966643 7 + 1.445 1.319 -0.436
ENSG00000095564 E022 71.9199935 0.0003721266 1.341348e-05 8.650110e-05 10 91966644 91966757 114 + 1.739 1.540 -0.678
ENSG00000095564 E023 49.4086800 0.0006980950 7.016986e-06 4.832583e-05 10 91980454 91980519 66 + 1.587 1.301 -0.988
ENSG00000095564 E024 40.0907245 0.0022389768 5.060460e-06 3.597062e-05 10 91980520 91980558 39 + 1.504 1.145 -1.256
ENSG00000095564 E025 57.5705300 0.0005331642 7.557301e-04 3.100009e-03 10 91981643 91981792 150 + 1.638 1.482 -0.532
ENSG00000095564 E026 64.2929536 0.0004919470 5.745785e-03 1.794375e-02 10 91982083 91982225 143 + 1.678 1.581 -0.328
ENSG00000095564 E027 0.4439371 0.0215590076 1.000000e+00 1.000000e+00 10 91982226 91982415 190 + 0.136 0.000 -8.502
ENSG00000095564 E028 74.2567076 0.0003277022 6.823370e-05 3.716376e-04 10 91982587 91982761 175 + 1.748 1.581 -0.566
ENSG00000095564 E029 82.8038825 0.0003046494 4.809898e-04 2.087358e-03 10 91984201 91984404 204 + 1.789 1.670 -0.403
ENSG00000095564 E030 121.9171934 0.0002492766 5.028709e-04 2.170693e-03 10 91989154 91989580 427 + 1.950 1.871 -0.266
ENSG00000095564 E031 77.4671484 0.0082564348 2.532696e-01 3.897675e-01 10 91992119 91992309 191 + 1.743 1.748 0.017
ENSG00000095564 E032 63.9402830 0.0024921572 1.227950e-01 2.239468e-01 10 91993694 91993847 154 + 1.665 1.646 -0.065
ENSG00000095564 E033 54.9899632 0.0004079521 1.148537e-02 3.231841e-02 10 91994535 91994644 110 + 1.611 1.518 -0.320
ENSG00000095564 E034 84.4698567 0.0003412129 3.227101e-01 4.660466e-01 10 91996369 91996570 202 + 1.776 1.806 0.104
ENSG00000095564 E035 73.4748752 0.0061668859 9.869056e-01 9.958683e-01 10 91997603 91997751 149 + 1.707 1.791 0.282
ENSG00000095564 E036 77.4967666 0.0039932956 8.211318e-01 8.872466e-01 10 92008123 92008275 153 + 1.727 1.826 0.334
ENSG00000095564 E037 59.5279995 0.0003885589 3.722020e-01 5.166588e-01 10 92008829 92008950 122 + 1.608 1.744 0.462
ENSG00000095564 E038 86.6075578 0.0026702069 1.890013e-01 3.124982e-01 10 92009041 92009208 168 + 1.765 1.920 0.523
ENSG00000095564 E039 53.9516826 0.0021122579 5.344909e-01 6.665375e-01 10 92011073 92011150 78 + 1.570 1.694 0.419
ENSG00000095564 E040 58.6875526 0.0004243006 1.934386e-01 3.180961e-01 10 92011286 92011415 130 + 1.597 1.757 0.543
ENSG00000095564 E041 72.6829987 0.0003656735 3.378561e-01 4.817357e-01 10 92013667 92013808 142 + 1.694 1.829 0.456
ENSG00000095564 E042 79.2045379 0.0004639928 1.706931e-01 2.890562e-01 10 92013899 92014029 131 + 1.727 1.882 0.520
ENSG00000095564 E043 91.3261232 0.0003695488 1.529135e-02 4.114858e-02 10 92016340 92016465 126 + 1.781 1.978 0.664
ENSG00000095564 E044 102.4252533 0.0025837720 4.333233e-02 9.716960e-02 10 92018783 92018935 153 + 1.832 2.017 0.623
ENSG00000095564 E045 122.3957427 0.0027922041 7.601641e-03 2.277571e-02 10 92024756 92024967 212 + 1.902 2.112 0.704
ENSG00000095564 E046 114.1284004 0.0016490706 8.854966e-02 1.729091e-01 10 92026592 92026751 160 + 1.882 2.045 0.547
ENSG00000095564 E047 118.6522456 0.0002694137 1.603606e-02 4.281503e-02 10 92027130 92027300 171 + 1.893 2.077 0.617
ENSG00000095564 E048 83.5149585 0.0007654962 6.206132e-05 3.416141e-04 10 92028790 92028929 140 + 1.720 1.998 0.935
ENSG00000095564 E049 357.4734271 0.0210171238 2.988793e-16 1.211939e-14 10 92028930 92031469 2540 + 2.241 2.856 2.050
ENSG00000095564 E050 2.1118853 0.2133472240 8.589984e-02 1.688242e-01 10 92031568 92031744 177 + 0.297 0.776 2.337
ENSG00000095564 E051 0.5964967 0.0245200098 5.728673e-01 6.989091e-01 10 92052186 92052439 254 + 0.136 0.270 1.227