ENSG00000095485

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354105 ENSG00000095485 HEK293_OSMI2_2hA HEK293_TMG_2hB CWF19L1 protein_coding protein_coding 29.3407 26.67574 32.24919 6.582654 0.6935268 0.2736412 20.442052 20.7312158 20.23132 5.7591889 1.3496633 -0.03519699 0.70050000 0.76500000 0.6262 -0.13880000 6.752049e-02 5.981586e-13 FALSE  
MSTRG.4491.10 ENSG00000095485 HEK293_OSMI2_2hA HEK293_TMG_2hB CWF19L1 protein_coding   29.3407 26.67574 32.24919 6.582654 0.6935268 0.2736412 1.581123 0.5669003 3.17948 0.1702975 0.1479017 2.46692716 0.05370833 0.02076667 0.0986 0.07783333 5.981586e-13 5.981586e-13 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000095485 E001 0.7352249 0.2525329920 8.753789e-01 9.239720e-01 10 100232298 100232298 1 - 0.227 0.277 0.375
ENSG00000095485 E002 2.9787794 0.1042254829 8.195606e-01 8.860695e-01 10 100232299 100232304 6 - 0.647 0.571 -0.334
ENSG00000095485 E003 63.4712646 0.0077116645 1.389919e-03 5.273596e-03 10 100232305 100232487 183 - 1.692 1.892 0.678
ENSG00000095485 E004 405.3745261 0.0004891080 2.917938e-15 1.040457e-13 10 100232488 100232872 385 - 2.524 2.677 0.506
ENSG00000095485 E005 212.2447707 0.0003365937 9.248957e-10 1.380001e-08 10 100232873 100232972 100 - 2.246 2.398 0.506
ENSG00000095485 E006 77.8516183 0.0003698970 1.837606e-06 1.441110e-05 10 100232973 100232973 1 - 1.785 1.976 0.645
ENSG00000095485 E007 157.0808926 0.0002403847 8.057423e-12 1.702492e-10 10 100232974 100233024 51 - 2.086 2.280 0.650
ENSG00000095485 E008 136.3505943 0.0002471165 1.094849e-14 3.579220e-13 10 100233025 100233046 22 - 1.996 2.235 0.798
ENSG00000095485 E009 178.5756169 0.0005751620 1.269027e-22 1.085878e-20 10 100233047 100233109 63 - 2.081 2.365 0.948
ENSG00000095485 E010 319.4909533 0.0007302700 8.591279e-17 3.729588e-15 10 100233110 100233332 223 - 2.395 2.585 0.632
ENSG00000095485 E011 142.8000613 0.0002350149 3.934147e-03 1.295745e-02 10 100233333 100233371 39 - 2.119 2.202 0.277
ENSG00000095485 E012 215.9320589 0.0002314350 6.034514e-04 2.545695e-03 10 100235667 100235764 98 - 2.298 2.378 0.268
ENSG00000095485 E013 229.4894643 0.0005298533 1.983294e-02 5.113317e-02 10 100236850 100236969 120 - 2.340 2.395 0.184
ENSG00000095485 E014 275.6635822 0.0001986563 9.616609e-01 9.798553e-01 10 100238022 100238157 136 - 2.453 2.451 -0.007
ENSG00000095485 E015 157.5999730 0.0002573061 2.976791e-01 4.390274e-01 10 100238158 100238182 25 - 2.226 2.193 -0.110
ENSG00000095485 E016 182.1032240 0.0002418889 2.157950e-02 5.480785e-02 10 100238183 100238231 49 - 2.305 2.242 -0.214
ENSG00000095485 E017 198.8112996 0.0003514328 1.782023e-03 6.542489e-03 10 100243698 100243772 75 - 2.354 2.270 -0.280
ENSG00000095485 E018 115.0397217 0.0023422653 1.353526e-01 2.416108e-01 10 100243773 100243777 5 - 2.106 2.043 -0.210
ENSG00000095485 E019 109.5947567 0.0015910828 2.346482e-01 3.679430e-01 10 100245799 100245799 1 - 2.078 2.031 -0.160
ENSG00000095485 E020 165.2002058 0.0002209959 5.913382e-04 2.502004e-03 10 100245800 100245913 114 - 2.282 2.185 -0.322
ENSG00000095485 E021 2.0723324 0.0069739532 3.127255e-01 4.552504e-01 10 100245914 100246116 203 - 0.575 0.404 -0.841
ENSG00000095485 E022 169.4001932 0.0009161263 1.117038e-08 1.364759e-07 10 100246795 100246935 141 - 2.329 2.148 -0.606
ENSG00000095485 E023 3.1513742 0.0051231080 1.188526e-01 2.183100e-01 10 100250110 100250178 69 - 0.738 0.499 -1.056
ENSG00000095485 E024 95.1472348 0.0003161550 8.355054e-08 8.617847e-07 10 100250248 100250273 26 - 2.089 1.893 -0.660
ENSG00000095485 E025 133.4180039 0.0006644021 2.874308e-12 6.545606e-11 10 100250274 100250332 59 - 2.249 2.017 -0.777
ENSG00000095485 E026 172.0434731 0.0033811982 3.010722e-06 2.251855e-05 10 100253421 100253539 119 - 2.342 2.145 -0.661
ENSG00000095485 E027 2.4398687 0.2738708727 4.502089e-01 5.913517e-01 10 100253540 100254619 1080 - 0.648 0.410 -1.134
ENSG00000095485 E028 236.1627358 0.0020586064 6.420695e-09 8.209918e-08 10 100256262 100256476 215 - 2.479 2.285 -0.649
ENSG00000095485 E029 176.1117694 0.0010811278 6.612190e-07 5.710259e-06 10 100260218 100260319 102 - 2.337 2.175 -0.539
ENSG00000095485 E030 137.4282377 0.0002550097 5.007040e-08 5.399412e-07 10 100260966 100261028 63 - 2.234 2.066 -0.561
ENSG00000095485 E031 85.9107044 0.0003581046 2.842975e-08 3.214905e-07 10 100261029 100261044 16 - 2.054 1.840 -0.719
ENSG00000095485 E032 125.4606444 0.0064263320 2.435775e-03 8.569021e-03 10 100261979 100262063 85 - 2.194 2.019 -0.587
ENSG00000095485 E033 4.3650694 0.0201067390 5.813767e-04 2.464811e-03 10 100267002 100267143 142 - 0.950 0.405 -2.361
ENSG00000095485 E034 14.4441918 0.0012323229 1.572813e-04 7.796245e-04 10 100267435 100267517 83 - 1.356 1.022 -1.187
ENSG00000095485 E035 9.8985519 0.0017051731 2.615499e-03 9.112617e-03 10 100267518 100267521 4 - 1.199 0.890 -1.131
ENSG00000095485 E036 21.2068058 0.0022176906 5.738426e-04 2.436086e-03 10 100267522 100267570 49 - 1.486 1.221 -0.920
ENSG00000095485 E037 79.7369697 0.0084472279 1.119391e-02 3.163122e-02 10 100267571 100267680 110 - 1.999 1.825 -0.587