ENSG00000095397

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000265134 ENSG00000095397 HEK293_OSMI2_2hA HEK293_TMG_2hB WHRN protein_coding protein_coding 7.937044 9.447329 5.088354 0.8740673 0.1409444 -0.8914013 3.2273893 3.1479448 1.7914890 0.16523815 0.17474970 -0.8097961 0.41150000 0.33743333 0.35090000 0.013466667 0.9281008530 0.0002441998 FALSE TRUE
ENST00000374057 ENSG00000095397 HEK293_OSMI2_2hA HEK293_TMG_2hB WHRN protein_coding protein_coding 7.937044 9.447329 5.088354 0.8740673 0.1409444 -0.8914013 0.6051211 0.8913864 0.1147595 0.16776625 0.11475951 -2.8529959 0.06952083 0.09560000 0.02283333 -0.072766667 0.1714379674 0.0002441998 FALSE TRUE
ENST00000673811 ENSG00000095397 HEK293_OSMI2_2hA HEK293_TMG_2hB WHRN protein_coding retained_intron 7.937044 9.447329 5.088354 0.8740673 0.1409444 -0.8914013 1.0360403 0.5262547 0.9881718 0.08823995 0.15996078 0.8963697 0.14230417 0.05500000 0.19430000 0.139300000 0.0002441998 0.0002441998 TRUE TRUE
ENST00000674036 ENSG00000095397 HEK293_OSMI2_2hA HEK293_TMG_2hB WHRN protein_coding protein_coding 7.937044 9.447329 5.088354 0.8740673 0.1409444 -0.8914013 0.6445416 1.7649172 0.3659667 0.35789239 0.19395026 -2.2390750 0.06812917 0.18496667 0.07093333 -0.114033333 0.4045636175 0.0002441998 FALSE TRUE
ENST00000674048 ENSG00000095397 HEK293_OSMI2_2hA HEK293_TMG_2hB WHRN protein_coding retained_intron 7.937044 9.447329 5.088354 0.8740673 0.1409444 -0.8914013 0.9884928 0.8687029 0.7019312 0.05372922 0.25831474 -0.3036376 0.12677500 0.09253333 0.13970000 0.047166667 0.7806574632 0.0002441998 FALSE TRUE
MSTRG.33271.3 ENSG00000095397 HEK293_OSMI2_2hA HEK293_TMG_2hB WHRN protein_coding   7.937044 9.447329 5.088354 0.8740673 0.1409444 -0.8914013 0.6013245 0.7342502 0.3910903 0.08489247 0.08181594 -0.8918606 0.07254583 0.07800000 0.07666667 -0.001333333 0.9914006932 0.0002441998 FALSE TRUE
MSTRG.33271.7 ENSG00000095397 HEK293_OSMI2_2hA HEK293_TMG_2hB WHRN protein_coding   7.937044 9.447329 5.088354 0.8740673 0.1409444 -0.8914013 0.3882126 0.4302115 0.3450821 0.10125968 0.11972365 -0.3100441 0.05191250 0.04656667 0.06683333 0.020266667 0.7267578455 0.0002441998 FALSE TRUE
MSTRG.33271.8 ENSG00000095397 HEK293_OSMI2_2hA HEK293_TMG_2hB WHRN protein_coding   7.937044 9.447329 5.088354 0.8740673 0.1409444 -0.8914013 0.3016660 0.9499403 0.1667017 0.39392712 0.08335085 -2.4416288 0.03635417 0.09523333 0.03216667 -0.063066667 0.3025833227 0.0002441998 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000095397 E001 0.1482932 0.0414733544 1.000000e+00   9 114402080 114402080 1 - 0.001 0.090 7.140
ENSG00000095397 E002 7.2191125 0.0023952285 1.732087e-01 2.923622e-01 9 114402081 114402144 64 - 0.746 0.925 0.695
ENSG00000095397 E003 67.2077857 0.0007148638 1.599750e-04 7.917341e-04 9 114402145 114402475 331 - 1.653 1.838 0.627
ENSG00000095397 E004 61.5924293 0.0029765617 1.077111e-01 2.021633e-01 9 114402476 114402560 85 - 1.683 1.773 0.305
ENSG00000095397 E005 115.5196111 0.0003170444 5.819371e-03 1.813589e-02 9 114402561 114402936 376 - 1.951 2.049 0.329
ENSG00000095397 E006 58.2081804 0.0014506447 3.726352e-02 8.597462e-02 9 114403217 114403339 123 - 1.653 1.763 0.374
ENSG00000095397 E007 72.1776717 0.0004684438 3.362032e-01 4.800218e-01 9 114403896 114404074 179 - 1.791 1.835 0.146
ENSG00000095397 E008 24.5527043 0.0035462663 3.385274e-01 4.824025e-01 9 114404075 114404077 3 - 1.306 1.384 0.271
ENSG00000095397 E009 80.2265143 0.0008538122 5.637234e-01 6.911539e-01 9 114406355 114406640 286 - 1.884 1.861 -0.077
ENSG00000095397 E010 58.2082723 0.0004592967 2.001045e-01 3.263758e-01 9 114406641 114406892 252 - 1.772 1.712 -0.204
ENSG00000095397 E011 36.7915379 0.0006383984 5.197648e-01 6.538415e-01 9 114407947 114408018 72 - 1.565 1.527 -0.129
ENSG00000095397 E012 2.6862399 0.0057460556 7.549410e-02 1.523010e-01 9 114420037 114420069 33 - 0.282 0.603 1.718
ENSG00000095397 E013 51.6439882 0.0004523676 7.767628e-01 8.562565e-01 9 114423314 114423523 210 - 1.687 1.673 -0.047
ENSG00000095397 E014 62.3879710 0.0003856342 3.849252e-02 8.826624e-02 9 114424334 114424546 213 - 1.822 1.729 -0.316
ENSG00000095397 E015 33.1561626 0.0012744467 2.662523e-01 4.044250e-01 9 114424988 114425024 37 - 1.537 1.466 -0.241
ENSG00000095397 E016 48.2853154 0.0005129630 2.720018e-12 6.223420e-11 9 114425025 114426210 1186 - 1.862 1.515 -1.179
ENSG00000095397 E017 51.9970825 0.0015408117 2.460117e-02 6.105720e-02 9 114426211 114426413 203 - 1.755 1.638 -0.394
ENSG00000095397 E018 36.0879995 0.0005979420 2.027532e-01 3.296627e-01 9 114466267 114466392 126 - 1.575 1.499 -0.260
ENSG00000095397 E019 6.8397441 0.0653388098 1.970020e-03 7.132486e-03 9 114478321 114478552 232 - 0.376 0.969 2.595
ENSG00000095397 E020 61.2146586 0.0004735767 6.419621e-01 7.548977e-01 9 114478553 114478771 219 - 1.733 1.756 0.078
ENSG00000095397 E021 0.8114974 0.0579098577 5.312993e-01 6.637764e-01 9 114503107 114503173 67 - 0.164 0.283 1.009
ENSG00000095397 E022 0.5503986 0.0201418164 1.000000e+00 1.000000e+00 9 114503551 114503699 149 - 0.164 0.165 0.019
ENSG00000095397 E023 73.1510760 0.0077680976 7.774596e-01 8.567853e-01 9 114504184 114504739 556 - 1.810 1.831 0.070
ENSG00000095397 E024 18.7819599 0.0361579543 9.228932e-01 9.553697e-01 9 114504740 114504917 178 - 1.254 1.254 0.001
ENSG00000095397 E025 21.9560584 0.0214737779 9.223290e-01 9.549787e-01 9 114504918 114505015 98 - 1.325 1.318 -0.024
ENSG00000095397 E026 16.7870392 0.0312661870 9.339378e-01 9.623752e-01 9 114505016 114505051 36 - 1.207 1.220 0.047
ENSG00000095397 E027 15.6224229 0.0097967664 8.548570e-01 9.102249e-01 9 114505052 114505194 143 - 1.168 1.187 0.067
ENSG00000095397 E028 28.7996485 0.0079275136 5.006215e-01 6.368603e-01 9 114505195 114506325 1131 - 1.468 1.416 -0.178