ENSG00000095321

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318080 ENSG00000095321 HEK293_OSMI2_2hA HEK293_TMG_2hB CRAT protein_coding protein_coding 16.73071 29.07961 9.905037 1.371836 0.2759276 -1.552814 11.9391646 21.544568 6.9076172 0.89665112 0.22793224 -1.639647 0.70015833 0.7413 0.6996667 -0.04163333 7.203178e-01 2.796565e-16 FALSE  
ENST00000393384 ENSG00000095321 HEK293_OSMI2_2hA HEK293_TMG_2hB CRAT protein_coding protein_coding 16.73071 29.07961 9.905037 1.371836 0.2759276 -1.552814 1.3582325 2.672777 0.2810871 0.07787431 0.05745456 -3.204204 0.07440833 0.0922 0.0282000 -0.06400000 1.595462e-05 2.796565e-16 FALSE  
ENST00000458362 ENSG00000095321 HEK293_OSMI2_2hA HEK293_TMG_2hB CRAT protein_coding nonsense_mediated_decay 16.73071 29.07961 9.905037 1.371836 0.2759276 -1.552814 0.6635327 0.000000 0.8369457 0.00000000 0.15385138 6.404198 0.05710833 0.0000 0.0849000 0.08490000 2.796565e-16 2.796565e-16 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000095321 E001 2.6864158 0.2272275960 6.721498e-01 7.782279e-01 9 129094142 129094793 652 - 0.518 0.475 -0.212
ENSG00000095321 E002 7.3704245 0.0023658782 2.367248e-01 3.703930e-01 9 129094794 129094805 12 - 0.701 0.883 0.723
ENSG00000095321 E003 7.9261362 0.0023434187 9.612431e-01 9.795838e-01 9 129094806 129094810 5 - 0.864 0.883 0.071
ENSG00000095321 E004 23.8957018 0.0162399680 2.489697e-01 3.847123e-01 9 129094811 129094825 15 - 1.202 1.340 0.486
ENSG00000095321 E005 388.8950045 0.0045952033 1.012553e-04 5.276721e-04 9 129094826 129095396 571 - 2.368 2.532 0.546
ENSG00000095321 E006 121.2312587 0.0053955351 1.456257e-02 3.950393e-02 9 129095397 129095455 59 - 1.879 2.027 0.498
ENSG00000095321 E007 101.4697865 0.0090090966 7.359820e-02 1.492838e-01 9 129095456 129095496 41 - 1.815 1.947 0.444
ENSG00000095321 E008 156.2207515 0.0122298762 8.721104e-02 1.709118e-01 9 129095497 129095612 116 - 2.002 2.131 0.432
ENSG00000095321 E009 3.6461177 0.0048452500 3.373718e-01 4.812505e-01 9 129095838 129095997 160 - 0.435 0.617 0.865
ENSG00000095321 E010 127.4473148 0.0038499905 7.465249e-02 1.509836e-01 9 129095998 129096069 72 - 1.935 2.038 0.348
ENSG00000095321 E011 84.7720690 0.0004288297 1.240457e-02 3.450921e-02 9 129096070 129096090 21 - 1.736 1.870 0.455
ENSG00000095321 E012 93.8877060 0.0019028978 3.294166e-03 1.113357e-02 9 129096091 129096120 30 - 1.758 1.921 0.548
ENSG00000095321 E013 82.4441680 0.0026805073 1.617751e-02 4.311431e-02 9 129096121 129096135 15 - 1.717 1.863 0.493
ENSG00000095321 E014 0.2214452 0.0381812781 1.000000e+00   9 129096136 129096152 17 - 0.000 0.074 7.645
ENSG00000095321 E015 125.2441094 0.0003480338 2.697249e-01 4.082693e-01 9 129097250 129097312 63 - 1.968 2.024 0.189
ENSG00000095321 E016 2.4950749 0.0062250900 5.640647e-02 1.204332e-01 9 129097313 129098012 700 - 0.701 0.394 -1.445
ENSG00000095321 E017 178.7189454 0.0019902130 9.361016e-01 9.638219e-01 9 129098013 129098148 136 - 2.148 2.166 0.061
ENSG00000095321 E018 84.3779811 0.0021280791 1.025936e-01 1.944579e-01 9 129098249 129098259 11 - 1.889 1.822 -0.223
ENSG00000095321 E019 156.8775686 0.0002865601 2.487733e-03 8.727496e-03 9 129098260 129098371 112 - 2.170 2.085 -0.284
ENSG00000095321 E020 172.8649740 0.0004558486 3.411565e-04 1.544831e-03 9 129098531 129098650 120 - 2.223 2.123 -0.332
ENSG00000095321 E021 125.7077004 0.0002720396 4.273039e-01 5.701368e-01 9 129099866 129099966 101 - 2.023 2.007 -0.053
ENSG00000095321 E022 175.7817960 0.0010331131 2.840932e-02 6.883663e-02 9 129100511 129100689 179 - 2.200 2.140 -0.199
ENSG00000095321 E023 16.4167164 0.0012363252 3.055371e-09 4.138053e-08 9 129100690 129101743 1054 - 1.489 1.001 -1.725
ENSG00000095321 E024 8.1906117 0.0023345141 1.418447e-03 5.368076e-03 9 129101744 129101882 139 - 1.135 0.777 -1.343
ENSG00000095321 E025 97.6029450 0.0014393627 5.781447e-02 1.228827e-01 9 129101883 129101906 24 - 1.954 1.884 -0.237
ENSG00000095321 E026 176.1289721 0.0002177338 7.351643e-02 1.491467e-01 9 129101907 129102057 151 - 2.188 2.147 -0.140
ENSG00000095321 E027 107.9615967 0.0002951260 8.632472e-02 1.695185e-01 9 129102400 129102441 42 - 1.986 1.932 -0.183
ENSG00000095321 E028 106.1948622 0.0002801313 1.920282e-01 3.162938e-01 9 129102442 129102485 44 - 1.968 1.929 -0.130
ENSG00000095321 E029 121.2221865 0.0003564109 9.475299e-02 1.825016e-01 9 129102486 129102565 80 - 2.033 1.983 -0.166
ENSG00000095321 E030 5.6683327 0.0138216117 2.810500e-04 1.302703e-03 9 129102566 129103012 447 - 1.076 0.597 -1.886
ENSG00000095321 E031 108.9329628 0.0011150890 7.784098e-03 2.323785e-02 9 129103013 129103066 54 - 2.023 1.928 -0.321
ENSG00000095321 E032 68.8698359 0.0006699860 7.976613e-02 1.591936e-01 9 129104188 129104196 9 - 1.811 1.738 -0.248
ENSG00000095321 E033 116.3184442 0.0011062863 2.030122e-01 3.299847e-01 9 129104197 129104306 110 - 2.009 1.971 -0.128
ENSG00000095321 E034 29.5711732 0.0023132560 4.383296e-07 3.921246e-06 9 129107334 129107813 480 - 0.956 1.468 1.820
ENSG00000095321 E035 142.8053833 0.0033510664 4.770931e-01 6.157023e-01 9 129107814 129107933 120 - 2.028 2.075 0.159
ENSG00000095321 E036 126.4866388 0.0085974762 8.976812e-01 9.386827e-01 9 129107934 129108077 144 - 2.007 2.017 0.035
ENSG00000095321 E037 0.6621601 0.0175907337 2.601344e-01 3.976189e-01 9 129108078 129108407 330 - 0.332 0.136 -1.638
ENSG00000095321 E038 0.5514428 0.0196891738 4.650051e-01 6.047118e-01 9 129108408 129108478 71 - 0.000 0.191 9.227
ENSG00000095321 E039 8.3040151 0.0020080939 8.935636e-01 9.359321e-01 9 129108763 129108898 136 - 0.864 0.893 0.112
ENSG00000095321 E040 3.3345963 0.0191933820 8.972355e-01 9.383719e-01 9 129108899 129108903 5 - 0.588 0.575 -0.056
ENSG00000095321 E041 2.4668856 0.0084544662 7.924395e-01 8.672958e-01 9 129108904 129109102 199 - 0.518 0.481 -0.182
ENSG00000095321 E042 2.4220351 0.0756956399 3.633153e-01 5.077270e-01 9 129109103 129109178 76 - 0.588 0.428 -0.777
ENSG00000095321 E043 22.5377471 0.0118726595 2.804005e-01 4.202680e-01 9 129109179 129109277 99 - 1.347 1.259 -0.310
ENSG00000095321 E044 107.4603089 0.0196440184 1.933454e-01 3.179878e-01 9 129110483 129110793 311 - 2.004 1.928 -0.255
ENSG00000095321 E045 0.0000000       9 129110958 129111189 232 -