ENSG00000095209

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374692 ENSG00000095209 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM38B protein_coding protein_coding 16.18349 4.867731 26.3417 1.500304 0.3398529 2.433614 14.1661901 4.0707142 22.1569024 1.4249290 0.1442831 2.44151359 0.84820000 0.8176000 0.84130000 0.0237000 8.980289e-01 4.130332e-06 FALSE TRUE
ENST00000434214 ENSG00000095209 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM38B protein_coding protein_coding 16.18349 4.867731 26.3417 1.500304 0.3398529 2.433614 0.6580686 0.0000000 1.8798420 0.0000000 0.3747166 7.56212182 0.02967917 0.0000000 0.07120000 0.0712000 4.130332e-06 4.130332e-06   FALSE
ENST00000451560 ENSG00000095209 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM38B protein_coding protein_coding 16.18349 4.867731 26.3417 1.500304 0.3398529 2.433614 0.4526810 0.5197519 0.5465062 0.0531972 0.1842555 0.07108093 0.06696250 0.1307667 0.02073333 -0.1100333 1.309042e-02 4.130332e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000095209 E001 0.5891098 0.0172671820 6.559503e-01 0.7657334242 9 105694464 105694524 61 + 0.188 0.000 -11.520
ENSG00000095209 E002 0.5891098 0.0172671820 6.559503e-01 0.7657334242 9 105694525 105694526 2 + 0.188 0.000 -11.517
ENSG00000095209 E003 0.7342825 0.0169355449 4.705362e-01 0.6097659194 9 105694527 105694533 7 + 0.224 0.000 -11.839
ENSG00000095209 E004 2.0660940 0.0070514126 5.306614e-02 0.1146005796 9 105694534 105694540 7 + 0.461 0.000 -13.325
ENSG00000095209 E005 2.2112666 0.0066527773 4.280615e-02 0.0961902994 9 105694541 105694543 3 + 0.481 0.000 -13.424
ENSG00000095209 E006 3.7237503 0.0069905915 2.083545e-01 0.3365058750 9 105694544 105694549 6 + 0.613 0.409 -0.987
ENSG00000095209 E007 5.2266569 0.0108185829 1.799705e-01 0.3011461407 9 105694550 105694552 3 + 0.726 0.525 -0.878
ENSG00000095209 E008 42.8459648 0.0005839845 1.752830e-01 0.2950380951 9 105694553 105694610 58 + 1.531 1.499 -0.109
ENSG00000095209 E009 142.6401201 0.0002924428 5.403872e-02 0.1163284077 9 105694611 105694772 162 + 2.041 2.032 -0.031
ENSG00000095209 E010 0.1451727 0.0482046097 1.000000e+00   9 105700984 105701643 660 + 0.055 0.000 -9.517
ENSG00000095209 E011 4.2920206 0.0036079138 1.163154e-01 0.2147050593 9 105702707 105702822 116 + 0.667 0.409 -1.219
ENSG00000095209 E012 140.1001112 0.0002323715 3.752509e-01 0.5196611135 9 105705597 105705674 78 + 2.027 2.059 0.109
ENSG00000095209 E013 150.4679503 0.0002567137 1.666495e-04 0.0008208000 9 105705675 105705753 79 + 2.076 1.995 -0.270
ENSG00000095209 E014 2.8213673 0.0362852714 2.389260e-02 0.0595842945 9 105714366 105714505 140 + 0.552 0.000 -13.766
ENSG00000095209 E015 221.6423881 0.0002177349 4.256578e-04 0.0018728133 9 105721537 105721686 150 + 2.237 2.193 -0.147
ENSG00000095209 E016 144.8476450 0.0002129205 3.168265e-05 0.0001874101 9 105721687 105721721 35 + 2.063 1.963 -0.334
ENSG00000095209 E017 221.2936670 0.0001850808 1.600460e-02 0.0427442808 9 105722534 105722621 88 + 2.231 2.225 -0.022
ENSG00000095209 E018 226.2276255 0.0002106322 2.962474e-01 0.4374507438 9 105748073 105748190 118 + 2.234 2.269 0.119
ENSG00000095209 E019 3.7654657 0.0040560509 9.170497e-01 0.9515976640 9 105749073 105749075 3 + 0.584 0.616 0.144
ENSG00000095209 E020 8.6862563 0.0020227049 1.201379e-01 0.2201903593 9 105749076 105749111 36 + 0.824 1.078 0.952
ENSG00000095209 E021 2.6174455 0.0072542879 2.463184e-03 0.0086532303 9 105749112 105749282 171 + 0.318 0.862 2.537
ENSG00000095209 E022 740.7088985 0.0086114451 4.075712e-04 0.0018035396 9 105773865 105776629 2765 + 2.715 2.891 0.588