ENSG00000095139

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264028 ENSG00000095139 HEK293_OSMI2_2hA HEK293_TMG_2hB ARCN1 protein_coding protein_coding 76.82899 72.08429 92.87594 7.759389 3.308683 0.3655751 59.572954 35.776757 84.762023 2.1497292 2.8954541 1.244162 0.7547083 0.50533333 0.91276667 0.4074333 2.364915e-17 6.387494e-42 FALSE TRUE
ENST00000534182 ENSG00000095139 HEK293_OSMI2_2hA HEK293_TMG_2hB ARCN1 protein_coding protein_coding 76.82899 72.08429 92.87594 7.759389 3.308683 0.3655751 11.596254 32.890888 0.000000 7.6463236 0.0000000 -11.683911 0.1762750 0.44650000 0.00000000 -0.4465000 6.387494e-42 6.387494e-42 FALSE FALSE
MSTRG.6411.1 ENSG00000095139 HEK293_OSMI2_2hA HEK293_TMG_2hB ARCN1 protein_coding   76.82899 72.08429 92.87594 7.759389 3.308683 0.3655751 4.472185 2.865588 5.767445 0.6883255 0.2959911 1.006575 0.0552125 0.04103333 0.06203333 0.0210000 3.519676e-01 6.387494e-42 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000095139 E001 1.322270 0.2987478769 7.148380e-01 8.109258e-01 11 118572369 118572389 21 + 0.277 0.466 1.107
ENSG00000095139 E002 13.123007 0.0220604107 2.178761e-02 5.523424e-02 11 118572390 118572408 19 + 1.196 1.002 -0.700
ENSG00000095139 E003 57.301692 0.0091164008 1.631703e-02 4.342627e-02 11 118572409 118572423 15 + 1.776 1.699 -0.262
ENSG00000095139 E004 94.273455 0.0114581456 1.095506e-04 5.659676e-04 11 118572424 118572435 12 + 2.016 1.844 -0.579
ENSG00000095139 E005 239.467293 0.0067707058 2.575766e-05 1.556825e-04 11 118572436 118572550 115 + 2.401 2.287 -0.383
ENSG00000095139 E006 2.036858 0.0076664665 8.908799e-01 9.343091e-01 11 118573620 118573719 100 + 0.444 0.529 0.417
ENSG00000095139 E007 2.252893 0.0068856761 4.180749e-01 5.613711e-01 11 118573720 118573783 64 + 0.538 0.463 -0.365
ENSG00000095139 E008 441.771022 0.0033335144 1.777118e-11 3.548374e-10 11 118581246 118581401 156 + 2.674 2.535 -0.462
ENSG00000095139 E009 474.583889 0.0049378626 1.805712e-11 3.602429e-10 11 118581402 118581509 108 + 2.715 2.542 -0.575
ENSG00000095139 E010 749.436120 0.0023312334 1.041043e-20 7.277582e-19 11 118583179 118583358 180 + 2.911 2.747 -0.546
ENSG00000095139 E011 673.882391 0.0036912880 1.219468e-11 2.504331e-10 11 118583809 118584014 206 + 2.856 2.721 -0.448
ENSG00000095139 E012 535.115422 0.0025188986 2.843328e-12 6.478950e-11 11 118584480 118584644 165 + 2.752 2.633 -0.396
ENSG00000095139 E013 619.822634 0.0030132955 4.720568e-07 4.196610e-06 11 118590341 118590506 166 + 2.799 2.735 -0.212
ENSG00000095139 E014 593.746062 0.0011221628 3.247318e-07 2.982906e-06 11 118592709 118592856 148 + 2.767 2.742 -0.080
ENSG00000095139 E015 539.238681 0.0010589654 2.854526e-06 2.146810e-05 11 118593590 118593698 109 + 2.722 2.706 -0.052
ENSG00000095139 E016 605.155539 0.0008012683 1.166224e-07 1.170221e-06 11 118597707 118597911 205 + 2.772 2.755 -0.057
ENSG00000095139 E017 1664.733164 0.0003416667 1.776865e-08 2.091338e-07 11 118600625 118601635 1011 + 3.145 3.296 0.503
ENSG00000095139 E018 3459.009956 0.0083496174 1.910097e-14 6.035059e-13 11 118601636 118603033 1398 + 3.375 3.700 1.083