ENSG00000095015

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399503 ENSG00000095015 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K1 protein_coding protein_coding 3.134297 1.123194 5.098771 0.1361806 0.1662363 2.172582 0.7806015 0.04377721 2.2806724 0.04377721 0.19209835 5.412632 0.1973708 0.04723333 0.44706667 0.3998333 1.367800e-03 1.547441e-14 FALSE TRUE
ENST00000469188 ENSG00000095015 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K1 protein_coding retained_intron 3.134297 1.123194 5.098771 0.1361806 0.1662363 2.172582 0.3765695 0.64892920 0.2021131 0.14286724 0.03240636 -1.635290 0.2566958 0.56450000 0.03996667 -0.5245333 1.547441e-14 1.547441e-14 TRUE FALSE
MSTRG.26208.2 ENSG00000095015 HEK293_OSMI2_2hA HEK293_TMG_2hB MAP3K1 protein_coding   3.134297 1.123194 5.098771 0.1361806 0.1662363 2.172582 1.9771263 0.43048740 2.6159859 0.04022837 0.21313346 2.575686 0.5459125 0.38826667 0.51290000 0.1246333 3.483630e-01 1.547441e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000095015 E001 12.766088 0.0013972951 2.083664e-04 9.998325e-04 5 56815549 56816055 507 + 1.071 0.423 -2.709
ENSG00000095015 E002 0.000000       5 56820782 56820816 35 +      
ENSG00000095015 E003 12.974218 0.0015372092 1.072397e-01 2.014520e-01 5 56856600 56856750 151 + 1.047 0.831 -0.814
ENSG00000095015 E004 17.013305 0.0383302772 1.317082e-01 2.365093e-01 5 56859715 56859915 201 + 1.157 0.927 -0.842
ENSG00000095015 E005 18.431851 0.0009595418 6.002268e-05 3.315678e-04 5 56864734 56864934 201 + 1.215 0.633 -2.225
ENSG00000095015 E006 12.586133 0.0015205110 1.613531e-03 6.003698e-03 5 56865340 56865456 117 + 1.057 0.541 -2.072
ENSG00000095015 E007 16.285821 0.0011228904 5.106512e-03 1.621979e-02 5 56865829 56865977 149 + 1.153 0.774 -1.419
ENSG00000095015 E008 15.514540 0.0011578949 2.286611e-02 5.746236e-02 5 56871910 56872031 122 + 1.129 0.831 -1.110
ENSG00000095015 E009 17.228260 0.0010974757 1.617599e-04 7.995022e-04 5 56872641 56872722 82 + 1.187 0.633 -2.125
ENSG00000095015 E010 24.792477 0.0013645435 1.376061e-03 5.228349e-03 5 56872825 56873005 181 + 1.323 0.966 -1.281
ENSG00000095015 E011 26.786838 0.0008106362 2.701494e-02 6.602889e-02 5 56875032 56875310 279 + 1.341 1.126 -0.759
ENSG00000095015 E012 15.507878 0.0011579835 5.278463e-01 6.608176e-01 5 56878980 56879101 122 + 1.103 1.037 -0.241
ENSG00000095015 E013 11.887585 0.0014513413 3.318332e-01 4.754698e-01 5 56880711 56880802 92 + 1.005 0.881 -0.467
ENSG00000095015 E014 20.088987 0.0030144006 8.521344e-02 1.677606e-01 5 56881083 56881272 190 + 1.225 1.037 -0.677
ENSG00000095015 E015 109.651011 0.0003073786 1.086674e-08 1.330751e-07 5 56881570 56882866 1297 + 1.944 1.658 -0.963
ENSG00000095015 E016 30.038997 0.0006611592 1.203125e-04 6.154241e-04 5 56883527 56883679 153 + 1.405 1.003 -1.428
ENSG00000095015 E017 28.954227 0.0033041584 1.267149e-02 3.513724e-02 5 56884664 56884826 163 + 1.375 1.126 -0.878
ENSG00000095015 E018 16.733340 0.0010391205 5.246947e-01 6.581596e-01 5 56885932 56885952 21 + 1.133 1.069 -0.232
ENSG00000095015 E019 26.673374 0.0008063476 8.206746e-01 8.869145e-01 5 56885953 56886063 111 + 1.312 1.300 -0.042
ENSG00000095015 E020 27.736699 0.0008603169 5.119207e-01 6.468475e-01 5 56887378 56887520 143 + 1.333 1.282 -0.180
ENSG00000095015 E021 2.809726 0.0057872503 2.315206e-01 3.642779e-01 5 56887521 56888225 705 + 0.520 0.261 -1.488
ENSG00000095015 E022 23.800424 0.0009868387 8.927536e-01 9.354674e-01 5 56888226 56888357 132 + 1.266 1.263 -0.013
ENSG00000095015 E023 201.956054 0.0005047382 1.475556e-59 1.471261e-56 5 56893531 56896152 2622 + 2.083 2.480 1.328