ENSG00000095015

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-3 / 3
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000399503	ENSG00000095015	HEK293_OSMI2_2hA	HEK293_TMG_2hB	MAP3K1	protein_coding	protein_coding	3.134297	1.123194	5.098771	0.1361806	0.1662363	2.172582	0.7806015	0.04377721	2.2806724	0.04377721	0.19209835	5.412632	0.1973708	0.04723333	0.44706667	0.3998333	1.367800e-03	1.547441e-14	FALSE	TRUE
ENST00000469188	ENSG00000095015	HEK293_OSMI2_2hA	HEK293_TMG_2hB	MAP3K1	protein_coding	retained_intron	3.134297	1.123194	5.098771	0.1361806	0.1662363	2.172582	0.3765695	0.64892920	0.2021131	0.14286724	0.03240636	-1.635290	0.2566958	0.56450000	0.03996667	-0.5245333	1.547441e-14	1.547441e-14	TRUE	FALSE
MSTRG.26208.2	ENSG00000095015	HEK293_OSMI2_2hA	HEK293_TMG_2hB	MAP3K1	protein_coding		3.134297	1.123194	5.098771	0.1361806	0.1662363	2.172582	1.9771263	0.43048740	2.6159859	0.04022837	0.21313346	2.575686	0.5459125	0.38826667	0.51290000	0.1246333	3.483630e-01	1.547441e-14	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

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Columns:
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groupID
featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000095015	E001	12.766088	0.0013972951	2.083664e-04	9.998325e-04	5	56815549	56816055	507	+	1.071	0.423	-2.709
ENSG00000095015	E002	0.000000				5	56820782	56820816	35	+
ENSG00000095015	E003	12.974218	0.0015372092	1.072397e-01	2.014520e-01	5	56856600	56856750	151	+	1.047	0.831	-0.814
ENSG00000095015	E004	17.013305	0.0383302772	1.317082e-01	2.365093e-01	5	56859715	56859915	201	+	1.157	0.927	-0.842
ENSG00000095015	E005	18.431851	0.0009595418	6.002268e-05	3.315678e-04	5	56864734	56864934	201	+	1.215	0.633	-2.225
ENSG00000095015	E006	12.586133	0.0015205110	1.613531e-03	6.003698e-03	5	56865340	56865456	117	+	1.057	0.541	-2.072
ENSG00000095015	E007	16.285821	0.0011228904	5.106512e-03	1.621979e-02	5	56865829	56865977	149	+	1.153	0.774	-1.419
ENSG00000095015	E008	15.514540	0.0011578949	2.286611e-02	5.746236e-02	5	56871910	56872031	122	+	1.129	0.831	-1.110
ENSG00000095015	E009	17.228260	0.0010974757	1.617599e-04	7.995022e-04	5	56872641	56872722	82	+	1.187	0.633	-2.125
ENSG00000095015	E010	24.792477	0.0013645435	1.376061e-03	5.228349e-03	5	56872825	56873005	181	+	1.323	0.966	-1.281
ENSG00000095015	E011	26.786838	0.0008106362	2.701494e-02	6.602889e-02	5	56875032	56875310	279	+	1.341	1.126	-0.759
ENSG00000095015	E012	15.507878	0.0011579835	5.278463e-01	6.608176e-01	5	56878980	56879101	122	+	1.103	1.037	-0.241
ENSG00000095015	E013	11.887585	0.0014513413	3.318332e-01	4.754698e-01	5	56880711	56880802	92	+	1.005	0.881	-0.467
ENSG00000095015	E014	20.088987	0.0030144006	8.521344e-02	1.677606e-01	5	56881083	56881272	190	+	1.225	1.037	-0.677
ENSG00000095015	E015	109.651011	0.0003073786	1.086674e-08	1.330751e-07	5	56881570	56882866	1297	+	1.944	1.658	-0.963
ENSG00000095015	E016	30.038997	0.0006611592	1.203125e-04	6.154241e-04	5	56883527	56883679	153	+	1.405	1.003	-1.428
ENSG00000095015	E017	28.954227	0.0033041584	1.267149e-02	3.513724e-02	5	56884664	56884826	163	+	1.375	1.126	-0.878
ENSG00000095015	E018	16.733340	0.0010391205	5.246947e-01	6.581596e-01	5	56885932	56885952	21	+	1.133	1.069	-0.232
ENSG00000095015	E019	26.673374	0.0008063476	8.206746e-01	8.869145e-01	5	56885953	56886063	111	+	1.312	1.300	-0.042
ENSG00000095015	E020	27.736699	0.0008603169	5.119207e-01	6.468475e-01	5	56887378	56887520	143	+	1.333	1.282	-0.180
ENSG00000095015	E021	2.809726	0.0057872503	2.315206e-01	3.642779e-01	5	56887521	56888225	705	+	0.520	0.261	-1.488
ENSG00000095015	E022	23.800424	0.0009868387	8.927536e-01	9.354674e-01	5	56888226	56888357	132	+	1.266	1.263	-0.013
ENSG00000095015	E023	201.956054	0.0005047382	1.475556e-59	1.471261e-56	5	56893531	56896152	2622	+	2.083	2.480	1.328

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000095015

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3