ENSG00000095002

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000233146 ENSG00000095002 HEK293_OSMI2_2hA HEK293_TMG_2hB MSH2 protein_coding protein_coding 39.52808 10.5681 67.66733 0.3222833 1.76646 2.677592 18.073779 9.5117770 25.656002 0.4124735 2.3125612 1.430556 0.6105333 0.89970000 0.37790000 -0.52180000 1.033390e-15 1.03339e-15 FALSE TRUE
MSTRG.18349.10 ENSG00000095002 HEK293_OSMI2_2hA HEK293_TMG_2hB MSH2 protein_coding   39.52808 10.5681 67.66733 0.3222833 1.76646 2.677592 2.462164 0.0000000 3.990227 0.0000000 0.8148837 8.643938 0.0522750 0.00000000 0.05883333 0.05883333 2.723645e-09 1.03339e-15 FALSE TRUE
MSTRG.18349.11 ENSG00000095002 HEK293_OSMI2_2hA HEK293_TMG_2hB MSH2 protein_coding   39.52808 10.5681 67.66733 0.3222833 1.76646 2.677592 12.554178 0.3370489 25.698494 0.3370489 3.1967239 6.210962 0.2116542 0.03006667 0.38053333 0.35046667 2.110138e-02 1.03339e-15 FALSE TRUE
MSTRG.18349.7 ENSG00000095002 HEK293_OSMI2_2hA HEK293_TMG_2hB MSH2 protein_coding   39.52808 10.5681 67.66733 0.3222833 1.76646 2.677592 5.749036 0.4848725 11.315227 0.4493392 1.9769245 4.516339 0.1036667 0.04766667 0.16783333 0.12016667 1.566008e-01 1.03339e-15 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000095002 E001 0.5933762 0.0219444600 5.898212e-01 7.128267e-01 2 47403067 47403118 52 + 0.189 0.000 -10.658
ENSG00000095002 E002 2.2217620 0.0067442259 4.498804e-02 1.001760e-01 2 47403119 47403129 11 + 0.484 0.000 -14.429
ENSG00000095002 E003 3.4062107 0.0227834414 1.107250e-02 3.134052e-02 2 47403130 47403134 5 + 0.617 0.000 -14.978
ENSG00000095002 E004 4.1425695 0.0153287499 4.230639e-03 1.378751e-02 2 47403135 47403139 5 + 0.683 0.000 -15.278
ENSG00000095002 E005 8.6512304 0.0365949414 6.800300e-03 2.070351e-02 2 47403140 47403147 8 + 0.937 0.407 -2.304
ENSG00000095002 E006 12.2307490 0.0179099757 1.589535e-01 2.737345e-01 2 47403148 47403152 5 + 1.040 0.858 -0.684
ENSG00000095002 E007 18.5798888 0.0188515756 1.642797e-01 2.807426e-01 2 47403153 47403155 3 + 1.201 1.046 -0.558
ENSG00000095002 E008 20.3731409 0.0080093390 9.558995e-02 1.837754e-01 2 47403156 47403159 4 + 1.240 1.075 -0.590
ENSG00000095002 E009 31.3503766 0.0015167798 5.958271e-02 1.259107e-01 2 47403160 47403175 16 + 1.414 1.276 -0.483
ENSG00000095002 E010 160.1134055 0.0016989246 2.180841e-06 1.682017e-05 2 47403176 47403359 184 + 2.115 1.929 -0.621
ENSG00000095002 E011 114.7805329 0.0009607581 1.370430e-02 3.754992e-02 2 47403360 47403402 43 + 1.958 1.870 -0.297
ENSG00000095002 E012 80.7483361 0.0117959967 4.094565e-01 5.530623e-01 2 47408401 47408403 3 + 1.797 1.767 -0.104
ENSG00000095002 E013 125.1533510 0.0119456687 1.467822e-01 2.572929e-01 2 47408404 47408460 57 + 1.992 1.924 -0.229
ENSG00000095002 E014 204.1750335 0.0007442556 3.540946e-12 7.940596e-11 2 47408461 47408555 95 + 2.227 1.981 -0.821
ENSG00000095002 E015 431.2611419 0.0001564586 5.834844e-22 4.628952e-20 2 47410094 47410372 279 + 2.547 2.333 -0.714
ENSG00000095002 E016 292.8976457 0.0009004144 2.118258e-05 1.306010e-04 2 47412414 47412560 147 + 2.366 2.260 -0.355
ENSG00000095002 E017 245.1381643 0.0014680266 4.608796e-02 1.021973e-01 2 47414269 47414418 150 + 2.279 2.238 -0.137
ENSG00000095002 E018 282.6568130 0.0001615138 1.122598e-07 1.130097e-06 2 47416296 47416429 134 + 2.354 2.225 -0.429
ENSG00000095002 E019 372.3801679 0.0001744836 3.499048e-08 3.886971e-07 2 47429742 47429941 200 + 2.470 2.357 -0.376
ENSG00000095002 E020 245.0009670 0.0001893974 2.967336e-02 7.132019e-02 2 47445548 47445657 110 + 2.278 2.241 -0.123
ENSG00000095002 E021 219.2064063 0.0002175605 6.485823e-03 1.988591e-02 2 47463031 47463154 124 + 2.234 2.174 -0.199
ENSG00000095002 E022 278.0105662 0.0001652167 2.482245e-01 3.838368e-01 2 47466658 47466808 151 + 2.326 2.324 -0.008
ENSG00000095002 E023 136.2315421 0.0002630464 1.110654e-01 2.071066e-01 2 47470965 47470987 23 + 2.024 1.988 -0.120
ENSG00000095002 E024 212.5012381 0.0002016864 2.993532e-02 7.183134e-02 2 47470988 47471062 75 + 2.216 2.174 -0.140
ENSG00000095002 E025 407.2684443 0.0003013572 1.877747e-02 4.884773e-02 2 47475025 47475270 246 + 2.496 2.469 -0.089
ENSG00000095002 E026 301.9738782 0.0001600283 1.788486e-01 2.996944e-01 2 47476367 47476508 142 + 2.350 2.416 0.218
ENSG00000095002 E027 213.3420591 0.0001725043 4.848549e-05 2.741024e-04 2 47476509 47476571 63 + 2.181 2.333 0.508
ENSG00000095002 E028 462.5446566 0.0002083117 1.589736e-11 3.201559e-10 2 47478272 47478519 248 + 2.513 2.681 0.560
ENSG00000095002 E029 407.7185942 0.0022038395 4.392616e-07 3.928841e-06 2 47480696 47480871 176 + 2.455 2.638 0.609
ENSG00000095002 E030 191.8374553 0.0031435193 5.874888e-06 4.117573e-05 2 47482779 47482782 4 + 2.121 2.336 0.717
ENSG00000095002 E031 328.7480047 0.0033641321 1.916930e-16 7.955237e-15 2 47482783 47482972 190 + 2.325 2.642 1.056
ENSG00000095002 E032 130.3896663 0.0245807595 2.398065e-11 4.698099e-10 2 47482973 47483223 251 + 1.822 2.416 1.988
ENSG00000095002 E033 1.1771729 0.0415278906 4.066993e-01 5.503301e-01 2 47483371 47483421 51 + 0.226 0.409 1.196
ENSG00000095002 E034 0.2924217 0.0272382544 1.000000e+00   2 47490920 47490970 51 + 0.105 0.000 -11.502
ENSG00000095002 E035 0.1817044 0.0407812216 7.245713e-02   2 47499771 47499798 28 + 0.000 0.250 13.058
ENSG00000095002 E036 0.0000000       2 47510038 47510323 286 +      
ENSG00000095002 E037 0.0000000       2 47510823 47510951 129 +      
ENSG00000095002 E038 1.0673886 0.0772748034 9.454124e-01 9.697299e-01 2 47512303 47512420 118 + 0.260 0.250 -0.074
ENSG00000095002 E039 0.9254501 0.0132873532 2.960252e-01 4.371924e-01 2 47512421 47513234 814 + 0.189 0.407 1.508
ENSG00000095002 E040 0.0000000       2 47555859 47555948 90 +      
ENSG00000095002 E041 2.8367006 0.0052399594 4.936282e-04 2.135711e-03 2 47562089 47567156 5068 + 0.320 0.903 2.679
ENSG00000095002 E042 0.0000000       2 47607392 47607581 190 +      
ENSG00000095002 E043 0.0000000       2 47632802 47632885 84 +      
ENSG00000095002 E044 0.4417591 0.1051497129 5.941432e-02 1.256361e-01 2 47632886 47634309 1424 + 0.056 0.404 3.493
ENSG00000095002 E045 0.0000000       2 47657200 47657292 93 +      
ENSG00000095002 E046 0.0000000       2 47660973 47660991 19 +      
ENSG00000095002 E047 0.1515154 0.0429613853 1.000000e+00   2 47660992 47663146 2155 + 0.056 0.000 -10.403