ENSG00000094975

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263688 ENSG00000094975 HEK293_OSMI2_2hA HEK293_TMG_2hB SUCO protein_coding protein_coding 10.56613 3.859141 16.28951 0.5811945 0.4793626 2.074743 2.492938 0.0000000 5.6444251 0.00000000 0.4927491 9.143237 0.1864875 0.0000000 0.34880000 0.34880000 4.596648e-17 4.596648e-17 FALSE TRUE
ENST00000609685 ENSG00000094975 HEK293_OSMI2_2hA HEK293_TMG_2hB SUCO protein_coding retained_intron 10.56613 3.859141 16.28951 0.5811945 0.4793626 2.074743 1.115132 2.3787289 0.4201039 0.73425903 0.1622889 -2.473486 0.2608542 0.5865000 0.02573333 -0.56076667 2.756162e-07 4.596648e-17 FALSE FALSE
ENST00000616058 ENSG00000094975 HEK293_OSMI2_2hA HEK293_TMG_2hB SUCO protein_coding protein_coding 10.56613 3.859141 16.28951 0.5811945 0.4793626 2.074743 1.707195 0.4760900 2.3249411 0.09299017 0.3897457 2.264091 0.1428042 0.1283000 0.14160000 0.01330000 8.715538e-01 4.596648e-17 FALSE TRUE
MSTRG.2600.7 ENSG00000094975 HEK293_OSMI2_2hA HEK293_TMG_2hB SUCO protein_coding   10.56613 3.859141 16.28951 0.5811945 0.4793626 2.074743 3.725009 0.5591134 5.8819802 0.01406412 0.8394918 3.371964 0.2787500 0.1534000 0.35876667 0.20536667 4.434473e-03 4.596648e-17 FALSE TRUE
MSTRG.2600.9 ENSG00000094975 HEK293_OSMI2_2hA HEK293_TMG_2hB SUCO protein_coding   10.56613 3.859141 16.28951 0.5811945 0.4793626 2.074743 1.034332 0.3667900 1.0189884 0.16554986 0.3737945 1.449394 0.0831625 0.1137333 0.06396667 -0.04976667 8.696013e-01 4.596648e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000094975 E001 0.0000000       1 172532349 172532472 124 +      
ENSG00000094975 E002 0.0000000       1 172532473 172532798 326 +      
ENSG00000094975 E003 0.0000000       1 172532799 172532799 1 +      
ENSG00000094975 E004 7.8831539 0.0248187614 8.258062e-01 8.903373e-01 1 172533118 172533149 32 + 0.759 0.849 0.356
ENSG00000094975 E005 10.0630831 0.0025053159 8.476767e-01 9.054148e-01 1 172533150 172533176 27 + 0.839 1.002 0.618
ENSG00000094975 E006 9.1364871 0.0155889292 9.021967e-01 9.416765e-01 1 172533177 172533177 1 + 0.804 0.958 0.588
ENSG00000094975 E007 10.3125167 0.0195072992 8.177843e-01 8.847953e-01 1 172533178 172533182 5 + 0.858 0.958 0.379
ENSG00000094975 E008 11.7725635 0.0059543911 2.759559e-01 4.153600e-01 1 172533183 172533212 30 + 0.928 0.905 -0.087
ENSG00000094975 E009 30.2120766 0.0010531146 1.207931e-02 3.372570e-02 1 172533213 172533382 170 + 1.314 1.206 -0.377
ENSG00000094975 E010 34.3510731 0.0077756837 5.664997e-03 1.772681e-02 1 172533383 172533497 115 + 1.374 1.231 -0.499
ENSG00000094975 E011 36.9640414 0.0121320142 1.743586e-03 6.419408e-03 1 172551512 172551626 115 + 1.407 1.205 -0.704
ENSG00000094975 E012 1.3149733 0.2645140424 3.873859e-01 5.315201e-01 1 172551627 172552152 526 + 0.288 0.000 -14.342
ENSG00000094975 E013 29.7630829 0.0006457407 1.335626e-02 3.674883e-02 1 172553260 172553329 70 + 1.309 1.206 -0.362
ENSG00000094975 E014 24.6238123 0.0019087121 1.468856e-03 5.535956e-03 1 172553330 172553370 41 + 1.241 1.002 -0.861
ENSG00000094975 E015 52.7934469 0.0006617543 2.363539e-07 2.233801e-06 1 172555869 172556023 155 + 1.561 1.257 -1.050
ENSG00000094975 E016 54.6012915 0.0068133617 2.227835e-07 2.116633e-06 1 172557280 172557417 138 + 1.578 1.207 -1.285
ENSG00000094975 E017 59.6110326 0.0003900005 1.696421e-10 2.878991e-09 1 172557644 172557794 151 + 1.618 1.206 -1.423
ENSG00000094975 E018 25.1372293 0.0007796823 9.546669e-05 5.007857e-04 1 172569019 172569026 8 + 1.254 0.905 -1.269
ENSG00000094975 E019 48.1314624 0.0008471230 4.741467e-06 3.393233e-05 1 172569027 172569142 116 + 1.519 1.258 -0.906
ENSG00000094975 E020 42.6154381 0.0044388167 8.739620e-03 2.563630e-02 1 172570047 172570171 125 + 1.455 1.364 -0.314
ENSG00000094975 E021 0.1515154 0.0428091382 8.247538e-01   1 172570172 172570513 342 + 0.044 0.000 -11.180
ENSG00000094975 E022 30.6419069 0.0006573375 1.621638e-01 2.779272e-01 1 172570663 172570730 68 + 1.307 1.324 0.061
ENSG00000094975 E023 1.5457785 0.0087821089 2.731697e-03 9.468115e-03 1 172570731 172570796 66 + 0.153 0.780 3.578
ENSG00000094975 E024 40.9755062 0.0005455539 5.112123e-02 1.111683e-01 1 172573891 172573998 108 + 1.430 1.417 -0.044
ENSG00000094975 E025 50.6169201 0.0004567859 1.836949e-02 4.794176e-02 1 172575518 172575623 106 + 1.522 1.494 -0.096
ENSG00000094975 E026 15.5006950 0.0011808523 4.174360e-02 9.426387e-02 1 172577539 172577559 21 + 1.046 0.905 -0.522
ENSG00000094975 E027 41.6061577 0.0005371599 7.690571e-03 2.300069e-02 1 172577764 172577819 56 + 1.443 1.364 -0.274
ENSG00000094975 E028 47.4309672 0.0004809954 1.702760e-01 2.885381e-01 1 172578298 172578389 92 + 1.486 1.534 0.165
ENSG00000094975 E029 33.2440981 0.0006108818 9.120837e-01 9.482525e-01 1 172579202 172579267 66 + 1.325 1.465 0.485
ENSG00000094975 E030 35.1254584 0.0005994301 5.557126e-02 1.189556e-01 1 172585018 172585086 69 + 1.368 1.345 -0.081
ENSG00000094975 E031 46.4975557 0.0545108703 6.365354e-02 1.327832e-01 1 172585858 172585948 91 + 1.492 1.389 -0.353
ENSG00000094975 E032 65.5255348 0.0504775367 2.911664e-02 7.023070e-02 1 172588760 172588924 165 + 1.639 1.514 -0.425
ENSG00000094975 E033 22.7909317 0.0010877969 4.213448e-03 1.374000e-02 1 172588925 172588930 6 + 1.206 1.002 -0.735
ENSG00000094975 E034 223.3851560 0.0137817163 7.320829e-04 3.014758e-03 1 172588931 172589926 996 + 2.158 2.093 -0.219
ENSG00000094975 E035 58.9317074 0.0071201747 3.442504e-02 8.057013e-02 1 172590984 172591071 88 + 1.583 1.561 -0.076
ENSG00000094975 E036 50.3189852 0.0006194740 4.059000e-01 5.495593e-01 1 172600064 172600168 105 + 1.502 1.594 0.313
ENSG00000094975 E037 40.5927504 0.0006152997 9.631006e-02 1.848447e-01 1 172602064 172602148 85 + 1.385 1.656 0.927
ENSG00000094975 E038 41.8495028 0.0012113279 2.859812e-02 6.920734e-02 1 172602149 172602218 70 + 1.387 1.693 1.047
ENSG00000094975 E039 57.6828402 0.0005239578 3.478591e-02 8.123574e-02 1 172602696 172602787 92 + 1.528 1.809 0.952
ENSG00000094975 E040 3.8585643 0.0650053939 9.138023e-01 9.494285e-01 1 172602788 172603205 418 + 0.521 0.606 0.386
ENSG00000094975 E041 2.4046243 0.0094145577 9.498356e-01 9.726203e-01 1 172608313 172608746 434 + 0.394 0.479 0.447
ENSG00000094975 E042 51.3300112 0.0004839931 7.404767e-01 8.298889e-01 1 172608747 172608802 56 + 1.500 1.674 0.593
ENSG00000094975 E043 535.4045396 0.0351155020 3.701544e-07 3.361035e-06 1 172609816 172611833 2018 + 2.441 2.925 1.611