ENSG00000094916

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000209875 ENSG00000094916 HEK293_OSMI2_2hA HEK293_TMG_2hB CBX5 protein_coding protein_coding 33.86521 26.11226 49.29846 3.040704 2.040711 0.9165557 23.275611 17.837391 30.834089 3.48744526 0.7030363 0.7892808 0.7004292 0.671500000 0.62646667 -0.04503333 7.564899e-01 6.288332e-07 FALSE TRUE
ENST00000439541 ENSG00000094916 HEK293_OSMI2_2hA HEK293_TMG_2hB CBX5 protein_coding protein_coding 33.86521 26.11226 49.29846 3.040704 2.040711 0.9165557 1.753030 0.192543 3.770191 0.06888932 0.7743369 4.2221590 0.0437625 0.008066667 0.07640000 0.06833333 6.161597e-04 6.288332e-07 FALSE TRUE
MSTRG.7409.4 ENSG00000094916 HEK293_OSMI2_2hA HEK293_TMG_2hB CBX5 protein_coding   33.86521 26.11226 49.29846 3.040704 2.040711 0.9165557 4.830282 2.812296 10.847128 1.42402810 0.9875347 1.9437015 0.1269333 0.119500000 0.22003333 0.10053333 3.391473e-01 6.288332e-07 FALSE TRUE
MSTRG.7409.9 ENSG00000094916 HEK293_OSMI2_2hA HEK293_TMG_2hB CBX5 protein_coding   33.86521 26.11226 49.29846 3.040704 2.040711 0.9165557 2.933564 4.436814 2.271243 0.62067012 0.4482606 -0.9629522 0.0968500 0.169733333 0.04546667 -0.12426667 6.288332e-07 6.288332e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000094916 E001 844.8158334 0.012177296 8.594334e-22 6.675567e-20 12 54230942 54231396 455 - 2.600 3.145 1.815
ENSG00000094916 E002 5926.6033477 0.002502671 9.088631e-02 1.765456e-01 12 54231397 54240624 9228 - 3.771 3.771 0.001
ENSG00000094916 E003 569.2736219 0.015467693 1.625998e-10 2.768406e-09 12 54240625 54241746 1122 - 2.888 2.496 -1.305
ENSG00000094916 E004 117.0549881 0.010414139 2.170476e-01 3.468262e-01 12 54241747 54241754 8 - 2.097 2.035 -0.208
ENSG00000094916 E005 279.0082257 0.005580822 9.924835e-02 1.893351e-01 12 54241755 54241905 151 - 2.470 2.416 -0.181
ENSG00000094916 E006 249.6301660 0.002655304 1.632042e-01 2.793355e-01 12 54246115 54246212 98 - 2.412 2.383 -0.094
ENSG00000094916 E007 154.0297013 0.004725384 3.815258e-01 5.258140e-01 12 54246213 54246215 3 - 2.200 2.178 -0.072
ENSG00000094916 E008 214.9041952 0.006193146 3.475423e-01 4.917753e-01 12 54252041 54252090 50 - 2.347 2.316 -0.102
ENSG00000094916 E009 293.9956998 0.007840788 2.182463e-01 3.482951e-01 12 54252091 54252227 137 - 2.491 2.439 -0.172
ENSG00000094916 E010 0.5117019 0.040808450 4.570212e-02 1.014866e-01 12 54252228 54252525 298 - 0.000 0.341 11.445
ENSG00000094916 E011 320.7512160 0.010034306 3.729724e-03 1.238227e-02 12 54257514 54257692 179 - 2.566 2.417 -0.498
ENSG00000094916 E012 0.0000000       12 54258069 54258427 359 -      
ENSG00000094916 E013 1.5293337 0.229000853 9.746751e-01 9.882131e-01 12 54259270 54259508 239 - 0.415 0.407 -0.047
ENSG00000094916 E014 8.4256761 0.108842316 1.035809e-01 1.959504e-01 12 54259509 54259592 84 - 1.087 0.764 -1.222
ENSG00000094916 E015 41.3252389 0.003900530 5.343208e-03 1.686585e-02 12 54271841 54273680 1840 - 1.689 1.546 -0.487
ENSG00000094916 E016 78.2532621 0.003699010 3.568653e-14 1.081713e-12 12 54273681 54274309 629 - 1.679 2.080 1.353
ENSG00000094916 E017 10.3783235 0.002052287 1.685355e-05 1.063005e-04 12 54274310 54274341 32 - 0.781 1.259 1.765
ENSG00000094916 E018 204.2553267 0.008746983 8.155009e-02 1.619759e-01 12 54280008 54280155 148 - 2.346 2.262 -0.280