ENSG00000094804

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000209728 ENSG00000094804 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC6 protein_coding protein_coding 41.442 21.77067 68.77406 1.873681 1.552478 1.659026 19.851733 15.027305 28.435828 1.5333965 0.6661822 0.9196711 0.52592917 0.6885333 0.4134667 -0.2750667 1.296983e-23 1.296983e-23 FALSE TRUE
ENST00000577249 ENSG00000094804 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC6 protein_coding protein_coding 41.442 21.77067 68.77406 1.873681 1.552478 1.659026 1.804393 0.092078 5.499903 0.0920780 0.8793527 5.7542830 0.03390833 0.0050000 0.0806000 0.0756000 1.386186e-02 1.296983e-23 FALSE FALSE
ENST00000580824 ENSG00000094804 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC6 protein_coding protein_coding 41.442 21.77067 68.77406 1.873681 1.552478 1.659026 19.216874 6.410662 34.061641 0.4195072 1.8581242 2.4077774 0.42412917 0.2955333 0.4946000 0.1990667 1.121687e-09 1.296983e-23 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000094804 E001 50.411299 0.0079964620 8.719855e-04 3.516135e-03 17 40287879 40287901 23 + 1.768 1.553 -0.731
ENSG00000094804 E002 62.032580 0.0044158875 2.455925e-04 1.156893e-03 17 40287902 40287906 5 + 1.852 1.659 -0.652
ENSG00000094804 E003 106.442992 0.0021226002 4.549844e-07 4.056637e-06 17 40287907 40287932 26 + 2.084 1.885 -0.666
ENSG00000094804 E004 129.787811 0.0002813127 3.925297e-09 5.213740e-08 17 40287933 40287949 17 + 2.164 1.988 -0.591
ENSG00000094804 E005 223.060113 0.0010646453 6.104923e-04 2.571389e-03 17 40287950 40288037 88 + 2.368 2.290 -0.261
ENSG00000094804 E006 190.105158 0.0045091743 2.304190e-01 3.629606e-01 17 40288038 40288090 53 + 2.282 2.249 -0.112
ENSG00000094804 E007 3.357004 0.0054051799 5.419749e-03 1.706935e-02 17 40288091 40288132 42 + 0.751 0.282 -2.345
ENSG00000094804 E008 1.176040 0.0123594543 6.631551e-01 7.713033e-01 17 40289192 40289407 216 + 0.285 0.375 0.563
ENSG00000094804 E009 430.418668 0.0005388699 5.828367e-11 1.069722e-09 17 40289408 40289598 191 + 2.664 2.552 -0.376
ENSG00000094804 E010 621.625864 0.0003094443 2.005598e-18 1.064299e-16 17 40291058 40291339 282 + 2.826 2.704 -0.405
ENSG00000094804 E011 1.636817 0.0313599041 2.328581e-01 3.658203e-01 17 40291467 40291468 2 + 0.490 0.281 -1.200
ENSG00000094804 E012 474.131399 0.0008451924 1.943249e-03 7.050653e-03 17 40291469 40291668 200 + 2.683 2.637 -0.153
ENSG00000094804 E013 499.339202 0.0001515740 9.481515e-04 3.781465e-03 17 40293456 40293631 176 + 2.701 2.669 -0.108
ENSG00000094804 E014 417.579978 0.0002172143 4.406564e-01 5.823297e-01 17 40293950 40294056 107 + 2.609 2.617 0.029
ENSG00000094804 E015 400.909549 0.0006118335 9.567964e-02 1.839124e-01 17 40294364 40294503 140 + 2.572 2.628 0.187
ENSG00000094804 E016 352.140573 0.0012900971 1.078727e-02 3.065685e-02 17 40295356 40295456 101 + 2.504 2.586 0.274
ENSG00000094804 E017 3.712271 0.1109263337 4.761550e-01 6.148267e-01 17 40295457 40295506 50 + 0.715 0.570 -0.624
ENSG00000094804 E018 322.069230 0.0004759849 6.373989e-03 1.959517e-02 17 40296703 40296767 65 + 2.467 2.548 0.272
ENSG00000094804 E019 303.258300 0.0002186002 3.781909e-03 1.253120e-02 17 40300828 40300889 62 + 2.442 2.526 0.281
ENSG00000094804 E020 441.838346 0.0017003173 4.163244e-03 1.360086e-02 17 40300890 40301030 141 + 2.599 2.694 0.316
ENSG00000094804 E021 6.017097 0.0300239747 6.073195e-01 7.273259e-01 17 40301031 40301467 437 + 0.861 0.809 -0.203
ENSG00000094804 E022 383.377449 0.0009504405 2.669383e-05 1.607357e-04 17 40301468 40301608 141 + 2.528 2.647 0.397
ENSG00000094804 E023 635.229300 0.0032905107 1.696461e-16 7.096257e-15 17 40301912 40304657 2746 + 2.675 2.936 0.867